Citric acid anhydrous, reagent grade, ACS 无水柠檬酸

规格: reagent grade, ACS
CAS: 77-92-9
产品编号: AC07190500
MDL: MFCD00011669
品牌: Scharlab
Chemical NameCitric acid
CAS Number77-92-9
PubChem Substance ID311
EC Number201-069-1
Beilstein Registry Number782061
MDL NumberMFCD00011669
Reaxys-RN782061
Merck Number2326
Synonym Citric acid {LY} Citric acid {} {LY} Citric acid {} {} {LY} Citric acid {} {} {} {LY} Citric acid {} {} {} {} {LY} Citric acid {} {} {} {} {} {LY} Citric acid {} {} {} {} {} {} {LY} Citric acid {} {} {} {} {} {} {} {LY} Citric acid {} {} {} {} {} {} {} {} {LY} Citric acid {} {} {} {} {} {} {} {} {} {LY} Citric acid {} {} {} {} {} {} {} {} {} {} {LY} Citric acid {} {} {} {} {} {} {} {} {} {} {} {LY} Citric acid {} {} {} {} {} {} {} {} {} {} {} {} {LY} Citric acid {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Citric acid {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Citric acid {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Citric acid {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Citric acid {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {}
Chemical Name Translation无水柠檬酸
InChIKeyKRKNYBCHXYNGOX-UHFFFAOYSA-N
Wiswesser Line NotationQV1XQVQ1VQ
LabNetwork Molecule IDLN00194688
InChIInChI=1S/C6H8O7/c7-3(8)1-6(13,5(11)12)2-4(9)10/h13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)
Canonical SMILESOC(CC(CC(O)=O)(C(O)=O)O)=O
GHS Symbol
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 2700 mg/kg
TOXIC EFFECTS :
   Lungs, Thorax, or Respiration - other changes
   Musculoskeletal - other changes
REFERENCE :
   TAKHAA Takeda Kenkyusho Ho.  Journal of the Takeda Research Laboratories.
   (Takeda Yakuhin Kogyo K.K., 2-17-85 Jusohon-machi, Yodogawa-ku, Osaka 532,
   Japan)  V.29-    1970-  Volume(issue)/page/year: 30,25,1971

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 5040 mg/kg
TOXIC EFFECTS :
   Lungs, Thorax, or Respiration - other changes
   Musculoskeletal - other changes
REFERENCE :
   TAKHAA Takeda Kenkyusho Ho.  Journal of the Takeda Research Laboratories.
   (Takeda Yakuhin Kogyo K.K., 2-17-85 Jusohon-machi, Yodogawa-ku, Osaka 532,
   Japan)  V.29-    1970-  Volume(issue)/page/year: 30,25,1971

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 290 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   TOVEFN Toksikologicheskii Vestnik.  (18-20 Vadkovskii per.  Moscow, 101479,
   Russia) History Unknown  Volume(issue)/page/year: (5),9,1994

TYPE OF TEST            : LD50 - Lethal do

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 42 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Lungs, Thorax, or Respiration - cyanosis
   Gastrointestinal - changes in structure or function of salivary glands
REFERENCE :
   JPETAB Journal of Pharmacology and Ex

WGK Germany1
Hazard statements
  • H303 May be harmfully swallowed 吞食可能有害
  • H315 Causes skin irritation 会刺激皮肤
  • H318 Causes serious eye damage 严重伤害眼睛
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
    Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves Eyeshields, Gloves
    Hazard Codes Xi
    RTECSGE7350000
    Precautionary statements
    • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
    • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
    • P264+P265
    • P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
    • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
    • P302+P352
    • P304+P340
    • P305+P351+P338
    • P305+P354+P338
    • P310 Immediately call a POISON CENTER or doctor/physician. 立即呼救解毒中心或医生/医师。
    • P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适，呼叫解毒中心或医生/医师。
    • P317
    • P319
    • P321 Specific treatment (see … on this label). 具体治疗（见本标签上的）。
    • P332+P313
    • P332+P317
    • P337+P313
    • P337+P317
    • P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服，清洗后方可重新使用
    • P362+P364
    • P403+P233
    • P405 Store locked up. 上锁保管。
    • P501 Dispose of contents/container to..… 处理内容物/容器.....
      Signal word Danger Warning
      Safety Statements
      • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
      • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
      • S37/39 Wear suitable gloves and eye/face protection 穿戴适当的手套和眼睛/面保护；
      • S39 Wear eye/face protection 戴眼睛/面孔保护装置；
      • S60 This material and its container must be disposed of as hazardous waste 该物质及其容器必须作为危险废物处置；
        Risk Statements
        • R36 Irritating to eyes 刺激眼睛
        • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
        • R37/38 Irritating to respiratory system and skin 对呼吸系统和皮肤有刺激性
        • R41 Risk of serious damage to eyes 有严重损伤眼睛的危险
          Storage condition 2-8°C {LY} 2-8°C Hygroscopic {} {LY} 2-8°C {} {} {LY} 2-8°C {} {} {} {LY} 2-8°C {} {} {} {} {LY} 2-8°C {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {
        • 同柠檬酸。
        • {MCE} [2]. Abdel-Salam OM, et al. Citric acid effects on brain and liver oxidative stress in lipopolysaccharide-treated mice. J Med Food. 2014 May;17(5):588-98.
        • {MCE} [3]. Lacour B, et al. Stimulation by citric acid of calcium and phosphorus bioavailability in rats fed a calcium-rich diet. Miner Electrolyte Metab. 1997;23(2):79-87.
        • {MCE} [4]. Nagai R, et al. Citric acid inhibits development of cataracts, proteinuria and ketosis in streptozotocin (type 1) diabetic rats. Biochem Biophys Res Commun. 2010 Feb 26;393(1):118-22.
        • {ALD} Merck: 14,2326
        • {ALD} Merck: 14,2326
        • Beilstein:3(4)1272
        • {uni_hamburg} Short: III/10a
        • {uni_hamburg} Short: III/5a
        • {uni_hamburg} Short: IV/1a
        • {MCE} [1]. Ying TH, et al. Citric acid induces cell-cycle arrest and apop
        • {MCE} [1]. Ying TH, et al. Citric acid induces cell-cycle arrest and apoptosis of human immortalized keratinocyte cell line (HaCaT) via caspase- and mitochondrial-dependent signaling pathways. Anticancer Res. 2013 Oct;33(10):4411-20.
          • 77-92-9 AC07190500 Citric acid anhydrous, reagent grade, ACS 无水柠檬酸

          化学属性

          Mol. FormulaC6H8O7
          Mol. Weight192.12
          Melting Point153-159°C
          Density1.542
          TSCAYes
          Flash Point100 ºC
          SolubilitySoluble in alcohol, water (750 mg/ml at 20 °C), and methanol. Insoluble in chloroform, and benzenz.
          Stability对湿度敏感
          Boiling Point248.08 °C at 760 mmHg

          *以上化合物性质及应用等信息仅供参考