Formic acid, 98 - 100%, extra pure, FCC 甲酸,超纯级

规格: 98 - 100%, extra pure, FCC
CAS: 64-18-6
产品编号: AC10861000
MDL: MFCD00003297
品牌: Scharlab
Chemical NameFormic acid
Synonym Kwas metaniowy Kyselina mravenci Formylic acid 无水甲酸 蚁酸 Ameisensaeure 甲酸 溶液 Mierenzuur Methanoic acid 甲酸; Acido formico 甲酸 Acide formique 甲酸, 85% Formic acid Aminic acid RCRA waste number U123 甲酸根,用于离子色谱标准液 Hydrogen carboxylic acid
MDL NumberMFCD00003297
CAS Number64-18-6
PubChem Substance ID284
EC Number200-579-1
Beilstein Registry Number2(4)3
Merck Number4241
Chemical Name Translation甲酸
Reaxys-RN1209246
InChIKeyBDAGIHXWWSANSR-UHFFFAOYSA-N
Wiswesser Line NotationVHQ
LabNetwork Molecule IDLN00193468
InChIInChI=1S/CH2O2/c2-1-3/h1H,(H,2,3)
GHS Symbol
TYPE OF TEST            : LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 15 gm/m3/15M
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
   GTPZAB Gigiena Truda i Professional'nye Zabolevaniya.  Labor Hygiene and
   Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
   V.1-36, 1957-1992. For publisher

TYPE OF TEST            : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 3 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   HBTXAC "Handbook of Toxicology," 4 vols., Philadelphia, W.B. Saunders Co.,
   1956-59  Volume(issue)/page/year: 1,146,1955

TYPE OF TEST            : LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 15 gm/m3/15M
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
   GTPZAB Gigiena Truda i Professional'nye Zabolevaniya.  Labor Hygiene and
   Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
   V.1-36, 1957-1992. For publisher information, see MTPEEI
   Volume(issue)/page/year: 23(12),49,1979

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 239 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   HBTXAC "Handbook of Toxicology," 4 vols., Philadelphia, W.B. Sa

TYPE OF TEST            : Sex chromosome loss and nondisjunction
ROUTE OF E

TYPE OF TEST            : Mutation test systems - not otherwise specified
TEST SYSTEM             : Non-mammalian species Cells - not otherwise specified
DOSE/DURATION           : 100 mmol/L
REFERENCE :
   CAANAT Comptes Rendus de l'Association des Anatomistes.  (Nancy, France)
   V.1-56, 1899-1972.  For publisher information, see ANOBAU.
   Volume(issue)/page/year: 56,712,1972

TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Rodent - hamster Ovary
DOSE/DURATION           : 10 mmol/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 240,195,1990

TYPE OF TEST            : Sex chromosome loss and nondisjunction
ROUTE OF EXPOSURE       : Inhalati

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 70 ppm/3H
REFERENCE :
   AMNTA4 American Naturalist.  (Univ. of Chicago Press, Journals Div., POB
   37005, Chicago, IL 60637) V.1-    1867-  Volume(issue)/page/year:
   85,119,1951

TYPE OF TEST            : Phage inhibition capacity
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 100 mmol/L
REFERENCE :
   MDMIAZ Medycyna Doswiadczalna i Mikrobiologia.  For English translation, see
   EXMMAV.  (Ars Polona, POB 1001, 00-068 Warsaw 1, Poland)  V.1-    1949-
   Volume(issue)/page/year: 31,11,1979

TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Non-mammalian species Cells - not otherwise specified
DOSE/DURATION           : 100 mmol/L
REFERENCE :
   CAANAT Comptes Rendus de l'Association des Anatomistes.  (Nancy, France)
   V.1-56, 1899-1972.  For publisher information, see ANOBAU.
   Volume(issue)/page/year: 56,712,19

WGK Germany1
Hazard statements
  • H226 Flammable liquid and vapour 易燃液体和蒸气
  • H314 Causes severe skin burns and eye damage 导致严重的皮肤灼伤和眼睛损伤
  • H331 Toxic if inhaled 吸入中毒
  • H302 Harmful if swallowed 吞食有害
  • H315 Causes skin irritation 会刺激皮肤
  • H319 Causes serious eye irritation 严重刺激眼睛
    Personal Protective Equipment Eyeshields, Gloves Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
    RTECSLQ4900000
    Precautionary statements
    • P201 Obtain special instructions before use. 使用前获取专门指示。
    • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
    • P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
    • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
    • P301+P312+P330
    • P303+P361+P353
    • P304+P340+P310
    • P305+P351+P338
    • P305+P351+P338+P310
    • P310 Immediately call a POISON CENTER or doctor/physician. 立即呼救解毒中心或医生/医师。
    • P403+P233
    • P501 Dispose of contents/container to..… 处理内容物/容器.....
      Signal word Danger
      Packing GroupII
      UN Number 1779 UN1779
      Risk Statements
      • R10 Flammable 易燃
      • R34 Causes burns 会导致灼伤
      • R35 Causes severe burns 会导致严重灼伤
        Safety Statements
        • S23 Do not breathe gas/fumes/vapour/spray (appropriate wording to be specified by the manufacturer) 不要吸入气体/烟雾/蒸汽/喷雾;
        • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后,立即用大量水冲洗并征求医生意见;
        • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时,立即求医(可能时出示标签);
          Storage condition 密封保存 充氩保存 Hygroscopic
          Hazard Codes 8 C
          Hazard Class8/3
          Warnings 危化品目录(2015)
          Restrict 危险品
        • 还原剂,测定砷、铋、铝、铜、金、铟、铁、铅、锰、汞、钼、银和锌等,检定铈,铼和钨,检验芳香族伯胺和仲胺,测定分子量及结晶的溶剂,测定甲氧基,显微分析中用作固定剂,制造甲酸盐类。
        • {ALF} In the presence of Raney nickel alloy, reduces aromatic nitriles to aldehydes in high yield: J. Chem. Soc., 5775 (1965); for list of examples, see: Org. Synth. Coll., 6, 631 (1988).
        • {ALD} Merck: 14,4241
        • Beilstein:2(4)3
        • {ALD} Merck: 14,4241
        • {ALF} Dehydration with sulfuric acid can be used to generate CO in situ. Subsequent reaction with tertiary carbocations gives the corresponding carboxylic acid (the Koch-Haaf carboxylation). For examples, see: Org. Synth. Coll., 5, 20, 739 (1973); improved procedure: Synth. Commun., 19, 1945 (1989). 1,4-Diols in which one alcohol is tertiary give -lactones: Che
        • {ALF} Used in combination with formaldehyde in the Eschweiler-Clarke reductive methylation of amines, the formic acid acting as a hydride donor. Review: Org. React., 5, 290 (1949). For an example, see: Org. Synth. Coll., 3, 723 (1955).
        • {ALF} In combination with Selenium(IV)­ oxide, 12358, improved results have been obtained in the allylic oxidation of sterically-hindered olefins: Synth. Commun., 24, 29213 (1994).
        • {ALF} Instead of the unstable formic anhydride, formylations may be carried out with formic acid and acetic anhydride to generate the mixed acetic formic anhydride in situ. For a review, see: Tetrahedron, 46, 1081 (1990). This reagent has been used for the deoxygenation of tertiary amine oxides: Chem. Lett., 1517 (1985).
        • {ALF} Cleaves trityl groups selectively in the presence of benzylidene acetals or TBDMS ethers: T
        • {ALF} Hydrogen donor, in combination with Pd on carbon, in catalytic transfer hydrogenations; see, e.g.: Selective reduction of dinitroarenes to nitroanilines: J. Org. Chem., 45, 4992 (1980). Dehalogenation of aryl halides: Synthesis, 876 (1982). Hydrogenation of aromatic rings: Tetrahedron Lett., 33, 7477 (1992). See also Palladium, A12012, Cyclohexene, A11359, and Ammonium formate, A10699. For a comparative mechanistic study of formic acid and formate salts in hydrogenolysis of aryl chlorides, see: J. Org. Chem., 60, 1347 (1995).
        • 64-18-6 AC10861000 Formic acid, 98 - 100%, extra pure, FCC	甲酸,超纯级

          化学属性

          Mol. FormulaCH2O2
          Mol. Weight46
          Refractive index1.3690 to 1.3730
          Autoignition Point1004 °F
          Vapor Density1.6 (vs air)
          Boiling Point100-101
          Vapor Pressure44.8 mmHg ( 20 °C)
          Density1.22
          Melting Point8
          Flash Point57°C(lit.)
          TSCAYes
          SolubilityMISCIBLE
          Stability对湿度敏感
          pH:A

          *以上化合物性质及应用等信息仅供参考