Chemical Name | 1-Chloromethyl-4-Fluoro-1,4-Diazoniabicyclo[2.2.2]Octane Bis(Tetrafluoroborate) |
CAS Number | 140681-55-6 |
Alfabeta Name | FLUOROCHLOROMETHYLTRIETHYLENEDIAMINEBISTETRAFLUOROBORATE NN()---' |
MDL Number | MFCD00142607 |
Synonym |
1-(Chloromethyl)-4-fluoro-1,4-diazabicyclo[2.2.2]octane-1,4-diium tetrafluoroborate
{LY} 1-(Chloromethyl)-4-fluoro-1,4-diazabicyclo[2.2.2]octane-1,4-diium tetrafluoroborate
{} {LY} 1-(Chloromethyl)-4-fluoro-1,4-diazabicyclo[2.2.2]octane-1,4-diium tetrafluoroborate
{} {} {LY} 1-(Chloromethyl)-4-fluoro-1,4-diazabicyclo[2.2.2]octane-1,4-diium tetrafluoroborate
{} {} {} {LY} 1-(Chloromethyl)-4-fluoro-1,4-diazabicyclo[2.2.2]octane-1,4-diium tetrafluoroborate
{} {} {} {} {LY} 1-(Chloromethyl)-4-fluoro-1,4-diazabicyclo[2.2.2]octane-1,4-diium tetrafluoroborate
{} {} {} {} {} {LY} 1-(Chloromethyl)-4-fluoro-1,4-diazabicyclo[2.2.2]octane-1,4-diium tetrafluoroborate
{} {} {} {} {} {} {LY} 1-(Chloromethyl)-4-fluoro-1,4-diazabicyclo[2.2.2]octane-1,4-diium tetrafluoroborate
{} {} {} {} {} {} {} {LY} 1-(Chloromethyl)-4-fluoro-1,4-diazabicyclo[2.2.2]octane-1,4-diium tetrafluoroborate
{} {} {} {} {} {} {} {} {LY} 1-(Chloromethyl)-4-fluoro-1,4-diazabicyclo[2.2.2]octane-1,4-diium tetrafluo |
Beilstein Registry Number | 5368649 |
PubChem Substance ID | 2724933 |
EC Number | 414-380-4 |
Reaxys-RN | 5368649 |
Merck Number | 8425 |
Chemical Name Translation | 1-氯甲基-4-氟-1,4-二氮杂双环[2.2.2]辛烷二(四氟硼酸)盐 |
LabNetwork Molecule ID | LN00116353 |
InChI | InChI=1S/C7H14ClFN2.2BF4/c8-7-10-1-4-11(9,5-2-10)6-3-10;2*2-1(3,4)5/h1-7H2;;/q+2;2*-1 |
Canonical SMILES | ClC[N+]12CC[N+](CC2)(F)CC1.[2BF4-] |
Warnings |
IRRITANT, KEEP COLD, SELF-HEATING SOLID |
GHS Symbol
Precautionary statements | |
- P235+P410
- P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
- P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西,喝水或吸烟。
- P272 Contaminated work clothing should not be allowed out of the workplace. 污染的工作服不得带出工作场所。
- P273 Avoid release to the environment. 避免释放到环境中。
- P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
- P301+P312
- P301+P312+P330
- P302+P352+P333+P313+P362+P364
- P305+P351+P338
- P305+P351+P338+P310
- P310 Immediately call a POISON CENTER or doctor/physician. 立即呼救解毒中心或医生/医师。
- P407 Maintain air gap between stacks/pallets. 在堆叠/货板间保持气隙。
- P420 Store away from other materials. 远离其他材料。
- P501 Dispose of contents/container to..… 处理内容物/容器.....
|
Hazard statements | |
- H412 Harmfutoaquaticlifewithlonglastingeffects 对水生生物有害并具有长期影响。
- H317 May cause an allergic skin reaction 可能导致皮肤过敏
- H318 Causes serious eye damage 严重伤害眼睛
- H302 Harmful if swallowed 吞食有害
- H252 Self-heating in large quantities; may catch fire 自我释放大量的热;可能着火。
- H251 Self-heating: may catch fire 自我放热:可能着火
|
WGK Germany | 2 |
Signal word |
Danger |
Personal Protective Equipment |
dust mask type N95 (US), Eyeshields, Faceshields, Gloves |
Safety Statements | |
- S21 When using do not smoke 使用时,禁止吸烟;
- S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后,立即用大量水冲洗并征求医生意见;
- S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护;
- S61 Avoid release to the environment. Refer to special instructions/safety data sheet 避免释放到环境中,参考特别指示/安全收据说明书;
|
Packing Group | II |
UN Number |
3088
UN3088 |
Risk Statements | |
- R22 Harmful if swallowed 吞咽有害
- R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
- R41 Risk of serious damage to eyes 有严重损伤眼睛的危险
- R43 May cause sensitisation by skin contact 皮肤接触会产生过敏反应
- R52/53
|
Hazard Codes |
4.2
Xn,O,F,Xi |
Hazard Class | 4.2 |
Storage condition |
2-8°C
{LY} 2-8°C
{} {LY} 2-8°C
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{} {} {} {} {} {} {} {} {} {} {LY} 2-8°C
{} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C
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{} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C
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{ALF} SELECTFLUOR is a registered trademark of Air Products & Chemicals Inc.
{ALF} For use in the synthesis of fluorinated carbohydrates by reaction with glycals, see: J. Am. Chem. Soc., 119, 11743 (1997); J. Org. Chem., 64, 5264 (1999).
{ALF} Water- and organic-soluble reagent developed by R. E. Banks and co-workers for electrophilic fluorination of a variety of substrates under mild conditions: USP 5,086,178 (1992 to Air Products & Chemicals, Inc.); review: J. Fluorine Chem., 87, 1 (1998). In acetonitrile, activated aromatics can be fluorinated in good yield: J. Chem. Soc., Perkin 1., 2069 (1996). Less active substrates can be fluorinated in the presence of triflic acid: Israel J. Chem., 39, 207 (1999). In acetonitrile, vinylsilanes undergo fluorodesilylation to give vinyl fluorides with retention of configuration: Chem. Commun., 233 (2001).
{ALD} Merck: 14,8425
{ALF} Stabilized carbanions can be selectively mono- or difluorinated: J. Chem. Soc., Chem. Commun., 343 (1994); Tetrahedron, 51, 3587 (1995). Fluorinated steroids have been prepared from enol acetates or silyl enol ethers: J. Org. Chem., 58, 2791 (1993). 5-Fluoropyrimidine nucleosides can be obtained by treatment of protected nucleosides with the reagent in the presence of water or methanol, followed by elimination of the resulting fluorohydrin derivative: J. Org. Chem., 60, 7340 (1995).
{ALF} For application to N-fluorination of amines, see: Chem. Commun., 1196 (2001). Review of mechanistic insight and applications of the reagent: Angew. Chem. Int Ed., 44, 192 (2005). Brief feature on uses in synthesis: Synlett, 807 (2006). Review of electrophilic N-F fluorinating agents: Chem. Rev., 96, 1737 (1996).