Chemical Name | (Trifluoromethyl)trimethylsilane |
CAS Number | 81290-20-2 |
Alfabeta Name | TRIFLUOROMETHYLTRIMETHYLSILANE |
MDL Number | MFCD00145454 |
Synonym |
(TRIMETHYLSILYL)TRIFLUOROMETHANE
(Trifluoromethyl)-trimethylsilan
(Trifluoromethyl)trimethylsilane Ruppert 试剂 TFMTMS
(Trifluoromethyl)trimethylsilane Ruppert′s reagent Ruppert-Prakash reagent TFMTMS Triflu
(Trifluoromethyl)trimethylsilane 0.5M solution in THF 98%
(trifluromethyl)trimethylsilane
(三氟甲基)三甲基硅烷
Ruppert's Reagent
Ruppert's
Ruppert's Reagent
Rupperts Reagent
Ruppert’s Reagent
TFMTMS
TMS-CF3
TRIMETHYL(TRIFLUOROMETHYL)SILANE
TRIMETHYL(TRIFLUOROMETHYL)SILANE, 0.5M S OLUTION IN TETRAHYDROFURAN
TTMS
Trifluoromethyltrimethylsilane
Trimethyl(trifluoromethyl)silane
Trimethyl(trifluoromethyl)silane solution
Trimethyl-trifluoromethyl-silane
{} {} {un
三氟甲基三甲基硅烷 溶液 |
Beilstein Registry Number | 4241868 |
PubChem Substance ID | 552549 |
EC Number | 000-000-0 |
Reaxys-RN | 4241868 |
Merck Number | 9683 |
LabNetwork Molecule ID | LN00008699 |
Chemical Name Translation | 三甲硅基三氟甲烷 |
InChI | InChI=1S/C4H9F3Si/c1-8(2,3)4(5,6)7/h1-3H3 |
Warnings |
FLAMMABLE |
GHS Symbol
WGK Germany | 3 |
Hazard statements | |
- H335 May cause respiratory irritation 可能导致呼吸道刺激
- H225 Highly flammable liquid and vapour 高度易燃液体和蒸气
- H319 Causes serious eye irritation 严重刺激眼睛
- H351 Suspected of causing cancer 怀疑致癌
- H302 Harmful if swallowed 吞食有害
|
Personal Protective Equipment |
Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US) |
Precautionary statements | |
- P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking. 远离热源/火花/明火/热的表面。——禁止吸烟。
- P233 Keep container tightly closed. ?保持容器密闭。
- P240 Ground/bond container and receiving equipment. 与地面接触/连接集装箱和接受设备。
- P241+P242+P243
- P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
- P301+P312+P330
- P303+P361+P353
- P305+P351+P338
- P370+P378
- P403+P235
- P501 Dispose of contents/container to..… 处理内容物/容器.....
|
Signal word |
Danger |
Packing Group | II |
UN Number |
1993
UN 1993 3/PG 2 |
Risk Statements | |
- R11 Highly flammable 非常易燃
- R19 May form explosive peroxides 可能生成易爆的过氧化物质
- R22 Harmful if swallowed 吞咽有害
- R36/37 Irritating to eyes and respiratory system 对眼睛和呼吸系统有刺激性
- R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
|
Safety Statements | |
- S16 Keep away from sources of ignition - No smoking 远离火源,禁止吸烟;
- S23 Do not breathe gas/fumes/vapour/spray (appropriate wording to be specified by the manufacturer) 不要吸入气体/烟雾/蒸汽/喷雾;
- S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后,立即用大量水冲洗并征求医生意见;
- S29 Do not empty into drains 不要排入下水道;
- S33 Take precautionary measures against static discharges 对静电采取预防措施;
- S36 Wear suitable protective clothing 穿戴适当的防护服;
- S39 Wear eye/face protection 戴眼睛/面孔保护装置;
|
Storage condition |
Moisture Sensitive
对湿度敏感,易挥发,密封保存
2-8°C |
Hazard Codes |
3
F
F,Xi,Xn |
Hazard Class | 3 |
三氟甲基化试剂,醛和酮上添加三氟甲基基团。
{ALF} Alternatively, rapid and efficient trifluoromethylation of carbonyl compounds can be carried out at room temperature in DMSO, in the presence of molecular sieves, without fluoride or other basic catayst: Synlett, 112 (2006). The use of Tri-tert-butyl­phosphine, 10178 as a catalyst has also been advocated: Synlett, 267 (2006).
{ALF} For reviews of this and similar reagents, see: Chem. Rev., 97, 757 (1997); J. Fluorine Chem., 112, 123 (2001).
{ALF} In the presence of CsF and TMS-imidazole, aldimines are converted to ɑ-trifluoromethyl amines: Tetrahedron Lett., 40, 5475 (1999).
{ALF} In the presence of F-, aldehydes and ketones give, after hydrolysis of the intermediate silyl ethers, the trifluoromethyl carbinols: J. Am. Chem. Soc., 111, 393 (1989); J. Org. Chem., 56, 984 (1991); Org. Synth. Coll., 9, 711 (1998):
{ALD} Merck: 14,9683
{uni_hamburg} Short: III/35B
{uni_hamburg} Short: III/35F
{ALF} Similarly, alkyl or aryl thiocyanates are converted to the corresponding trifluoromethyl sulfides in generally good yields: Tetrahedron Lett., 38, 65 (1997). Selenocyanates behave similarly. Trifluoromethylation of aromatics bearing electron-withdrawing groups can be effected in the presence of KF, by displacement of nitro-, cyano- or chloro-substituents: J. Chem. Soc., Perkin 1, 3081 (1998).
{ALF} Valuable reagent for trifluoromethylation of electrophilic substrates.
{ALF} With a catalytic amount of TBAF, excellent yields of trifluoromethyl ketones can be obtained from methyl esters: Angew. Chem. Int. Ed., 37, 820 (1998).