2,6-Lutidine 2,6-二甲基吡啶

规格: 99%
CAS: 108-48-5
产品编号: H37539
MDL: MFCD00006345
品牌: INFI
Chemical Name2,6-Lutidine
CAS Number108-48-5
Synonym 2,6-Dimethylpyridine a,a'-Dimethylpyridine a,a'-Lutidine α,α'-Dimethylpyridine
MDL NumberMFCD00006345
EC Number203-587-3
Beilstein Registry Number105690
PubChem Substance ID87572032
Merck Number5616
Chemical Name Translation2,6-二甲基吡啶
Reaxys-RN105690
LabNetwork Molecule IDLN00199608
InChIInChI=1S/C7H9N/c1-6-4-3-5-7(2)8-6/h3-5H,1-2H3
GHS Symbol
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - guinea pig
DOSE/DURATION           : 2500 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J.,
   Prague, Czechoslovakia, Avicenum, 1986  Volume(issue)/page/year: -,845,1986

TYPE OF TEST            : LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 7500 ppm/1H
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J.,
   Prague, Czechoslovakia, Avicenum, 1986  Volume(issue)/page/year: -,845,1986

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 400 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J.,
   Prague, Czechoslovakia, Avicenum, 1986  Volume(issue)/page/year: -,845,1986

TYPE OF TEST            : Sex chromosome loss and nondisjunction
TEST SYSTEM             : Yeast - Saccharomyces cerevisiae
DOSE/DURATION           : 5000 ppm
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 163,23,1986

Signal word Warning
WGK Germany3
Safety Statements
  • S16 Keep away from sources of ignition - No smoking 远离火源，禁止吸烟；
  • S23 Do not breathe gas/fumes/vapour/spray (appropriate wording to be specified by the manufacturer) 不要吸入气体/烟雾/蒸汽/喷雾；
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
  • S36 Wear suitable protective clothing 穿戴适当的防护服；
  • S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
  • S60 This material and its container must be disposed of as hazardous waste 该物质及其容器必须作为危险废物处置；
    Risk Statements
    • R10 Flammable 易燃
    • R20/21/22 Harmful by inhalation, in contact with skin and if swallowed 吸入、皮肤接触和不慎吞咽有害
    • R22 Harmful if swallowed 吞咽有害
    • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
      Precautionary statements
      • P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking. 远离热源/火花/明火/热的表面。——禁止吸烟。
      • P233 Keep container tightly closed. ?保持容器密闭。
      • P240 Ground/bond container and receiving equipment. 与地面接触/连接集装箱和接受设备。
      • P241+P242+P243
      • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
      • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
      • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
      • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
      • P301+P312+P330
      • P302+P352+P332+P313+P362+P364
      • P305+P351+P338
      • P305+P351+P338+P337+P313
      • P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适，呼叫解毒中心或医生/医师。
      • P332+P313
      • P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服，清洗后方可重新使用
      • P370+P378
      • P403+P235
      • P501 Dispose of contents/container to..… 处理内容物/容器.....
        Hazard statements
        • H226 Flammable liquid and vapour 易燃液体和蒸气
        • H302 Harmful if swallowed 吞食有害
        • H315 Causes skin irritation 会刺激皮肤
        • H319 Causes serious eye irritation 严重刺激眼睛
        • H335 May cause respiratory irritation 可能导致呼吸道刺激
          Personal Protective Equipment Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
          RTECSOK9700000
          Packing GroupIII
          UN Number 1993
          Hazard Codes 3 Xn,F,Xi
          Storage condition -20°C Hygroscopic
          Hazard Class3
          Warnings 危化品目录(2015)
          Restrict 危险品
        • 用于合成各种治疗高血压病的药及急救药，另外还用作杀虫剂及助染剂
        • {ALD} Merck:14,5616
        • Beilstein:20(3/4)2776
        • {uni_hamburg} Short: II/24C
        • {ALF} Base catalyst for the silylation of highly-hindered secondary or tertiary alcohols by tert-Butyl­dimethyl­silyl­ trifluoromethanesulfonate, A12174.
        • {ALD} Merck:14,5616
        • {ALF} This hindered base has been recommended for the exhaustive methylation of aromatic amines: J. Org. Chem., 35, 1558 (1970), and for the Rosenmund reduction of acyl halides to aldehydes: Synthesis, 767 (1976).
        • {TRC} Van den Dool, H., et al.: J. Chromatogr.,11, 463 ( 1963), Radulovic, N., et al.: Phytother. Res., 20, 85 (2006),
        • {ALF} For monometallation with potassium amide in liquid ammonia, and subsequent carboethoxylation with diethyl carbonate, see: Org. Synth. Coll., 6, 611 (1988).
        • {uni_hamburg} Short: II/24B
          • 108-48-5 H37539 2,6-Lutidine 2,6-二甲基吡啶

          化学属性

          Mol. FormulaC7H9N
          Mol. Weight107
          Density0.92
          Refractive index1.4960 to 1.4990
          Boiling Point143-145
          Melting Point-6
          Flash Point33°C(lit.)
          TSCAYes
          Solubility微溶于热水，溶于乙醇、乙醚。
          pH:A

          *以上化合物性质及应用等信息仅供参考