Chemical Name | Sec-Butyllithium |
MDL Number | MFCD00009323 |
CAS Number | 598-30-1 |
EC Number | 209-927-7 |
Beilstein Registry Number | 3587206 |
Synonym |
sec-Butyllithium, 1.3M in cyclohexane, packaged under Argon in resealable ChemSealTM bottles
SEC-BUTYLLITHIUM SOLUTION, ~1.3 M IN CYC LOHEXANE
S-BUTYLLITHIUM: 11-12% IN CYCLOHEXANE (CA. 1M)
sec-Butyllithium solution
LITHIUM SEC-BUTYL
s-Butyllithium,11-12%incyclohexane(~1M)
LITHIUM-2-BUTANIDE
(1-methylpropyl)-lithiu
S-BULI
2-丁基锂; s-BuLi
仲丁基锂 溶液
sec-butyllithium, 1.3m in cyclohexane, packaged under argon in resealable chemseal
仲丁基锂, 1.3M IN CYCLOHEXANE, PACKAGED UNDER ARGON IN RES
2-丁基锂
Secondary Butyllithium
sec-Butyllithium, 1.3M solution in cyclohexane/hexane (92/8)
sec-Butyllithium,1Mincyclohexane
SEC-BUTYLLITHIUM: 12% (CA. 1.4M) SOL. IN CYCLOHEXANE
SEC-BUTYLLITHIUM,1.3MSOLUTIONINCYCLOHEXANE
Lithium, (1-methylpropyl)-
仲丁基锂
SEC-BUTYLLITHIUM
SEC-BUTYLLITHIUM, 1.4M SOLUTION IN CYCLOHEXANE
S-BUTYLLITHIUM
ButyllithiumincyclohexanecaMcolorlesslightyellow
仲丁基锂, 12% (CA 1.4M) SOLN. IN CYCLOHEXANE
sec-Buthyllithium |
PubChem Substance ID | 24851700 |
Chemical Name Translation | 仲丁基锂 |
LabNetwork Molecule ID | LN00226174 |
Safety Statements | |
- S16 Keep away from sources of ignition - No smoking 远离火源,禁止吸烟;
- S33 Take precautionary measures against static discharges 对静电采取预防措施;
- S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时,立即求医(可能时出示标签);
- S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后,立即用大量水冲洗并征求医生意见;
- S43 In case of fire use ... (indicate in the space the precise type of fire-fighting equipment. If water increases the risk add -?Never use water) 着火时使用(指明具体的消防器材种类,如果用水增加危险,注明“禁止用水”
- S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护;
- S62 If swallowed, do not induce vomiting: seek medical advice immediately and show this container or label where possible 吞食后不要催吐:立即求医并出示该容器或标签;
- S61 Avoid release to the environment. Refer to special instructions/safety data sheet 避免释放到环境中,参考特别指示/安全收据说明书;
- S23 Do not breathe gas/fumes/vapour/spray (appropriate wording to be specified by the manufacturer) 不要吸入气体/烟雾/蒸汽/喷雾;
- S57 Use appropriate containment to avoid environmental contamination 使用适当容器避免环境污染;
- S9 Keep container in a well-ventilated place 保持容器在通风良好的场所;
- S60 This material and its container must be disposed of as hazardous waste 该物质及其容器必须作为危险废物处置;
|
Packing Group | I |
UN Number |
UN3394
3394
UN 3394 4.2/PG 1 |
Risk Statements | |
- R17 Spontaneously flammable in air 在空气中能够自燃
- R15 Contact with water liberates extremely flammable gases 遇水会释放出极端易燃的气体
- R11 Highly flammable 非常易燃
- R67 Vapours may cause drowsiness and dizziness 蒸汽可能导致嗜睡和昏厥
- R65 Harmful: may cause lung damage if swallowed 若吞咽可能伤害肺部器官
- R34 Causes burns 会导致灼伤
- R50/53
- R51/53
- R66 Repeated exposure may cause skin dryness or cracking 反复接触可能导致皮肤干燥或皴裂
- R14/15 Reacts violently with water, liberating extremely flammable gases 遇水剧烈反应,释放出高度可燃气体
|
Storage condition |
储存温度2-8°C ;充氩气储存
Air & Moisture Sensitive
2-8°C
储存温度2-8°C |
WGK Germany | 2 |
Precautionary statements | |
- P273 Avoid release to the environment. 避免释放到环境中。
- P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P301+P310
- P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
- P305+P351+P338
- P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking. 远离热源/火花/明火/热的表面。——禁止吸烟。
|
Hazard statements | |
- H314 Causes severe skin burns and eye damage 导致严重的皮肤灼伤和眼睛损伤
- H410 Verytoxictoaquaticlifewithlonglastingeffects 对水生生物毒性非常大并具有长期影响。
- H304 May be fatal if swallowed and enters airways 吞食和进入呼吸道可能致命
- H336 May cause drowsiness or dizziness 肯能导致嗜睡或头晕
- H225 Highly flammable liquid and vapour 高度易燃液体和蒸气
|
GHS Symbol
Personal Protective Equipment |
Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
Signal word |
Danger |
Hazard Codes |
F;C;N
F,C,N |
Hazard Class | 4.3 |
Warnings |
危化品目录(2015) |
Restrict |
危险品 |
⑴. 也称异丁基锂,无色或微黄色透明液体。
⑵. 锂化剂。异戊二烯、丁二烯的聚合。制备氢化锂、四氢呋喃、苄基锂化合物。
⑶. 相对于正丁基锂而言,异丁基锂的碱性更强,金属化活性更高,亲核性更差。因此,对于正丁基锂无法作用的弱酸性底物的锂化反应如制备芳基、乙烯基、和烯丙基锂试剂时、以及在需要弱亲核性锂化试剂时,异丁基锂是不错的选择。
△与正丁基锂相似,异丁基锂参与的反应也应在给电子溶剂如乙醚、THF和二甲基乙烷(DME)中进行,目的是促进低阶有机锂的聚集。与三级多胺配体如HMPA、TMEDA或DABCO联合
有机催化反应
{ALF} Limited shelf life. During storage white precipitate of LiH may form.
{ALF} Widely used base for directed metallation reactions. For use in combination with TMEDA for ortho-lithiation of an N,N-dialkyl benzamide, and of 1-Boc-indoline at the 7-position, see: Org. Synth. Coll., 8, 124, 559 (1998).
{ALF} With KO-t-Bu forms a "superbasic" reagent (Schlosser's Base): Angew. Chem. Int. Ed., 12, 508 (1973). For use in the conversion of ɑß-unsaturated acetals to alkoxy dienes, see: J. Org. Chem., 59, 3494, 5458 (1994).
{ALD} Beilstein: 4,III,2035