研峰科技 Infinity Scientific

tert-Butanol 叔丁醇

规格: 99%, SpcDry, with molecular sieves, Water≤50 ppm (by K.F.), SpcSeal

CAS: 75-65-0

产品编号: H45251

MDL: MFCD00004464

品牌: INFI

Chemical Name	tert-Butyl Alcohol
Synonym	tert-Butanol {LY} tert-Butanol {} {LY} tert-Butanol {} {} {LY} tert-Butanol {} {} {} {LY} tert-Butanol {} {} {} {} {LY} tert-Butanol {} {} {} {} {} {LY} tert-Butanol {} {} {} {} {} {} {LY} tert-Butanol {} {} {} {} {} {} {} {LY} tert-Butanol {} {} {} {} {} {} {} {} {LY} tert-Butanol {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} tert-Butanol {} {} {} {} {} {} {} {} {} {} {LY} tert-Butanol {} {} {} {} {} {} {} {} {} {} {} {LY} tert-Butanol {} {} {} {} {} {} {} {} {} {} {} {} {LY} tert-Butanol {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} tert-Butanol {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} tert-Butanol {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} tert-Butanol {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} tert-Butanol {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {}
CAS Number	75-65-0
PubChem Substance ID	6386
EC Number	200-889-7
Beilstein Registry Number	906698
MDL Number	MFCD00004464
Reaxys-RN	906698
Merck Number	1542
Chemical Name Translation	叔丁醇
Wiswesser Line Notation	QX1&1&1
LabNetwork Molecule ID	LN00163781
InChI	InChI=1S/C4H10O/c1-4(2,3)5/h5H,1-3H3
Canonical SMILES	CC(C)(O)C

GHS Symbol

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 146 gm/kg/2Y-C
TOXIC EFFECTS :
   Tumorigenic - neoplastic by RTECS criteria
   Kidney, Ureter, Bladder - Kidney tumors
REFERENCE :
   NTPTR* National Toxicology Program Technical Report Series.  (Research
   Triangle Park, NC 27709) No.206-  Volume(issue)/page/year: NTP-TR-436,1995

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1540 gm/kg/2Y-C
TOXIC EFFECTS :
   Tumorigenic - neoplastic by RTECS criteria
   Endocrine - thyroid tumors
REFERENCE :
   NTPTR* National Toxicology Program Technical Report Series.  (Research
   Triangle Park, NC 27709) No.206-  Volume(issue)/page/year: NTP-TR-436,1995

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 399 mg/kg
TOXIC EFFECTS :
   Liver - other changes
REFERENCE :
   RCOCB8 Research Communications in Chemical Pathology and Pharmacology. (PJD
   Pub. Ltd., P.O. Box 966, Westbury, NY 11590)  V.1-    1970-
   Volume(issue)/page/year: 26,75,1979

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 3559 mg/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - corneal damage
   Cardiac - pulse rate
   Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
   IMSUAI Industrial Medicine and Surgery.  (Northbrook, IL)  V.18-42, 1949-73.
    For publisher information, see IOHSA5.  Volume(issue)/page/year: 41,31,1972

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1538 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans
   Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium)  V.4-   
   1898-  Volume(issue)/page/year: 135,330,1962

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Parenteral
SPECIES OBSERVED        : Amphibian - frog
DOSE/DURATION           : 12 gm/kg
TOXIC EFFECTS :
   Peripheral Nerve and Sensation - spastic paralysis with or without sensory
   change
   Behavioral - somnolence (general depressed activity)
REFERENCE :
   AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans
   Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium)  V.4-   
   1898-  Volum

TYPE OF TEST            : Cytogenetic analysis
ROUTE OF EXPOSURE       : Parenteral
TEST SYSTEM             : Insect - not otherwise specified
DOSE/DURATION           : 12500 mg/kg
REFERENCE :
   ENECEV Environment and Ecology. (Environment and Ecology, C/o Dr. S.K.
   Konar, Dept. of Zoology, Kalyani University, Kalyani 741253, West Bengal,
   India)  V.1-    1983-  Volume(issue)/page/year: 5,321,1989

TYPE OF TEST            : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 3500 ppm/7H
SEX/DURATION            : female 1-19 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
   FAATDF Fundamental and Applied Toxicology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1981-  Volume(issue)/page/year:
   12,469,1989

TYPE OF TEST            : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 2000 ppm/7H
SEX/DURATION            : female 1-19 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
REFERENCE :
   FAATDF Fundamental and Applied Toxicology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1981-  Volume(issue)/page/year:
   12,469,1989

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 135 gm/kg
SEX/DURATION            : female 6-20 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Newborn - live birth index (measured after birth)
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 222,294,1982

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 103 gm/kg
SEX/DURATION            : female 6-20 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Newborn - stillbirth
   Reproductive - Effects o

WGK Germany	1
Hazard Codes	3 F,T
Hazard statements
H332 Harmful if inhaled 吸入有害 H335 May cause respiratory irritation 可能导致呼吸道刺激 H225 Highly flammable liquid and vapour 高度易燃液体和蒸气 H319 Causes serious eye irritation 严重刺激眼睛 H370 Causes damage to organs 导致器官损伤 H331 Toxic if inhaled 吸入中毒 H301 Toxic if swallowed 吞食有毒 H311 Toxic in contact with skin 皮肤接触中毒
Personal Protective Equipment	Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
RTECS	EO1925000
Precautionary statements
P201 Obtain special instructions before use. 使用前获取专门指示。 P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking. 远离热源/火花/明火/热的表面。——禁止吸烟。 P240 Ground/bond container and receiving equipment. 与地面接触/连接集装箱和接受设备。 P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。 P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。 P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。 P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。 P303+P361+P353 P305+P351+P338 P332+P313 P337+P313 P501 Dispose of contents/container to..… 处理内容物/容器.....
Signal word	Danger
Safety Statements
S16 Keep away from sources of ignition - No smoking 远离火源，禁止吸烟； S46 If swallowed, seek medical advice immediately and show this container or label 食入时，立即求医并出示容器/标签； S9 Keep container in a well-ventilated place 保持容器在通风良好的场所；
Risk Statements
R11 Highly flammable 非常易燃 R20 Harmful by inhalation 吸入有害 R23/24/25 Toxic by inhalation, in contact with skin and if swallowed 吸入，皮肤接触及吞食都有毒 R36/37 Irritating to eyes and respiratory system 对眼睛和呼吸系统有刺激性 R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性 R39/23/24/25 Toxic: danger of very serious irreversible effects through inhalation, in contact with skin and if swallowed 毒性：吸入，皮肤接触和吞食都会产生十分严重的不可逆危险
UN Number	1120
Packing Group	II
Storage condition	-20°C {LY} -20°C {} {LY} -20°C {} {} {LY} -20°C {} {} {} {LY} -20°C {} {} {} {} {LY} -20°C {} {} {} {} {} {LY} -20°C {} {} {} {} {} {} {LY} -20°C {} {} {} {} {} {} {} {LY} -20°C {} {} {} {} {} {} {} {} {LY} -20°C {} {} {} {} {} {} {} {} {} {LY} -20°C {} {} {} {} {} {} {} {} {} {} {LY} -20°C {} {} {} {} {} {} {} {} {} {} {} {LY} -20°C {} {} {} {} {} {} {} {} {} {} {} {} {LY} -20°C {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} -20°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} -20°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} -20°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} -20°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} -20°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} -20°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} -20°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {
Hazard Class	3
Warnings	危化品目录(2015)
Restrict	危险品

A solvent and isomer of butanol.

{uni_hamburg} Short: II/25C

{ALD} Merck: 14,1542

Beilstein:1,379

{ALD} Merck: 14,1542

{ALF} For preparation of the Li salt and reaction with an acid chloride as an example of a method for esterification of hindered alcohols, see: Org. Synth. Coll., 6, 259 (1988). A general method for esterification of carboxylic acids using DCC and DMAP is illustrated for t-butyl ethyl fumarate: Org. Synth. Coll., 7, 93 (1990). For use of the same combination for the preparation of t-butyl esters of N-protected amino acids, see: Org. Prep. Proced. Int., 20, 180 (1988). See also Appendix 6.

化学属性

Refractive index	n20/D 1.387(lit.)
Melting Point	23-26
Flash Point	35°C
TSCA	Yes
Autoignition Point	896 °F
Vapor Density	2.5 (vs air)
Vapor Pressure	31 mmHg ( 20 °C)
Solubility	可溶
Stability	易吸潮
Boiling Point	83
Density	0.78
Mol. Formula	C4H10O
Mol. Weight	74.12
Danger-Level	甲类

*以上化合物性质及应用等信息仅供参考