Chemical Name | p-Toluenesulfonyl chloride |
CAS Number | 98-59-9 |
Alfabeta Name | METHYLBENZENESULFONYLCHLORIDE 4- |
MDL Number | MFCD00007450 |
EC Number | 202-684-8 |
Beilstein Registry Number | 607898 |
Synonym |
4-Methylphenylsulfonyl chloride
4-TOLUENESULFONYL CHLORIDE
4-Toluene sulfochloride; 4-Methylbenzenesulfonyl chloride; p-Toluenesulfonyl chloride; Toluene-4-sulfonyl chloride; 4-Toluolsulfonyl ch
4-Toluenesulfonyl chloride
4-methylbenzenesulfonyl chloride
4-甲基苯磺酰氯
4-甲苯磺酰基氯
p-Methylphenylsulfonyl chloride
p-Toluenesulfonyl ch
p-Tosyl chloride
p-toluolsulfonylchloride
Benzenesulfonyl chloride, 4-methyl-
P-TOLUENESULFONYL CHLORI
TOLUENE-4-SULFONYL CHLORIDE
TOS-CL
Toluene-4-sulfonyl chloride
Tosyl chloride
Tosylchloride
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对氯化甲苯砜
对甲苯磺酰氯 |
PubChem Substance ID | 7397 |
Merck Number | 9534 |
Reaxys-RN | 607898 |
Chemical Name Translation | 4-甲苯磺酰氯 |
LabNetwork Molecule ID | LN00173802 |
InChI | InChI=1S/C7H7ClO2S/c1-6-2-4-7(5-3-6)11(8,9)10/h2-5H,1H3 |
Warnings |
危化品目录(2015)
IRRITANT |
Signal word |
Danger |
GHS Symbol
WGK Germany | 1 |
Safety Statements | |
- S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后,立即用大量水冲洗并征求医生意见;
- S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护;
- S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时,立即求医(可能时出示标签);
- S60 This material and its container must be disposed of as hazardous waste 该物质及其容器必须作为危险废物处置;
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Risk Statements | |
- R29 Contact with water liberates toxic gas. 遇水释放出有毒气体
- R34 Causes burns 会导致灼伤
- R38 Irritating to skin 刺激皮肤
- R41 Risk of serious damage to eyes 有严重损伤眼睛的危险
|
Precautionary statements | |
- P234 Keep only in original container. 只保留在原来的容器中。
- P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
- P273 Avoid release to the environment. 避免释放到环境中。
- P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
- P301+P330+P331+P310
- P303+P361+P353
- P303+P361+P353+P310+P363
- P304+P340
- P304+P340+P310
- P305+P351+P338
- P305+P351+P338+P310
- P390 Absorb spillage to prevent material damage. 吸收溢出物,防止重大损害。
- P405 Store locked up. 上锁保管。
- P406 Store in corrosive resistant/… container with a resistant inner liner. 存放在耐腐蚀/具有耐性的内衬容器。
- P501 Dispose of contents/container to..… 处理内容物/容器.....
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Hazard statements | |
- H290 May be corrosive to metals 可能腐蚀金属。
- H315 Causes skin irritation 会刺激皮肤
- H318 Causes serious eye damage 严重伤害眼睛
- H317 May cause an allergic skin reaction 可能导致皮肤过敏
|
Personal Protective Equipment |
Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges |
RTECS | DB8929000 |
Packing Group | II |
UN Number |
3261
UN 3261 8/PG 2 |
Storage condition |
Moisture Sensitive
Store at RT.
密封保存。
充氩保存 |
Hazard Codes |
8 |
Hazard Class | 8 |
Restrict |
危险品 |
有机合成,染料、测定伯、仲胺类、酚类。
{ALF} Dehydrating agent, e.g. for conversion of ureas to carbodiimides: Org. Synth. Coll., 5, 555 (1973); Synthesis, 520 (1987).
{ALF} For a detailed study of the optimum conditions for the tosylation of primary and secondary alcohols in pyridine, see: J. Org. Chem., 51, 2386 (1986). For use of 1,4-Diazabicyclo[2.2.2]octane, A14003, as an alternative to pyridine in the tosylation of alcohols, see: Synthesis, 1433 (1997). In the presence of a carboxylic acid, the ester is formed in high yield: J. Am. Chem. Soc., 77, 6214 (1955); 79, 2146 (1957). Esterification of an unprotected amino acid can be effected by heating the tosylate salt with tosyl chloride in an alcohol solvent: J. Org. Chem., 48, 121 (1983).
{ALD} Merck: 14,9534
Beilstein:11,103
{uni_hamburg} Short: III/31b
{uni_hamburg} Short: III/20b
{ALF} In the presence of strong bases, 1,2-diols can be converted to epoxides: Synthesis, 706 (1977); 983 (1985); Synth. Commun., 23, 285 (1993), and 1,3-diols to oxetanes: Synthesis, 550 (1981).
{ALD} Merck: 14,9534
{ALF} N-Tosylation has been used to block the imidazole nucleus in histidine: Bull. Chem. Soc. Jpn., 42, 1466 (1969); 47, 3146 (1974), and arginine residues: Experientia, 24, 661 (1968), during peptide synthesis. Cleavage can be effected with HF. See Appendix 6.
{uni_hamburg} Short: II/2