Acetylcholine chloride 氯化乙酰胆碱

规格: 98%
CAS: 60-31-1
产品编号: H53173
MDL: MFCD00011698
品牌: INFI
Chemical NameAcetylcholine chloride
CAS Number60-31-1
Alfabeta NameACETYLOXYTRIMETHYLETHANAMINIUMCHLORIDE NNN2()---,,
MDL NumberMFCD00011698
Synonym ACH cholineacetate(ester),chloride 2-(乙酰氧基)-N,N,N-三甲基乙铵氯化物 氯化乙酰胆碱 乙酰氯化胆碱;2-(乙酰氧基)-N,N,N-三甲基乙铵氯化物;氯化乙酰氧基三甲基乙铵 Miochol 2-(Acetyloxy)-N,N,N-trimethylethanaminium chloride ARTEROCHOLINE Acetylcholinium chloride ACh arterocoline Acecoline miochol Acetylcholine chloride 氯化乙酰氧基三甲基乙铵 acetylcholinehydrochloride (2-Hydroxyethyl)trimethylammoniumchlorideacetate (2-Hydroxyethyl)trimethylammonium chloride acetate Ammonium, (2-hydroxyethyl)trimeth N-(2-HYDROXYETHYL)TRIMETHYLAMMONIUM CHLORIDE ACETATE Ovisot 氯乙酰胆碱 O-Acetylcholine chloride ACETYLCHOLINE CHLORIDE 2-Acetoxy-N,N,N-trimethylethanium ch 乙酰氯化胆碱; 2-(乙酰氧基)-N,N,N-三甲基乙铵氯化物; 氯化乙酰氧基三甲基乙铵; 乙酰基氯化胆碱 Acecholin achchloride choline,chlorideacetate 2-(ACETYLOXY)-N,N,N-TRIMETHYLETHANAMINIUM CHLORIDE ACECOLINE Arterocoline ACH chloride Ethanaminium,2-(acetyloxy)-N,N,N-trimethyl-,chloride ammonium,(2-hydroxyethyl)trimethyl-,chloride,acetate N-Ethyl-N-(2-methylphenyl)-butenamide 2-Acetoxyethyltrimethylammonium chloride 乙酰氯化胆碱 ACh 氯化乙酰胆碱 氯化乙酰胆碱, 98+% (2-羟乙基)乙酰三甲基氯化铵 acetylcholiniumchloride ACETYLCHOLINI CHLORIDUM Acetylcholine hydrochloride Ethanaminium, 2-(acetyloxy)-N,N,N-trimethyl-, chloride 乙酰基氯化胆碱 Choline, chloride acetate 2-ACETOXYETHYLTRIMETHYLAMMONIUM CHLORIDE 2-(acetyloxy)-n,n,n-trimethyl-ethanaminiuchloride TL 1505 acecholin
Beilstein Registry Number4(4)1446
PubChem Substance ID6060
EC Number200-468-8
Merck Number87
Chemical Name Translation氯化乙酰胆碱
Reaxys-RN3571875
Wiswesser Line Notation1VO2K1&1&1 &Q &G
LabNetwork Molecule IDLN00159362
InChIInChI=1S/C7H16NO2.ClH/c1-7(9)10-6-5-8(2,3)4;/h5-6H2,1-4H3;1H/q+1;/p-1
GHS Symbol
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 22 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 58,337,1936

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 10 mg/kg
TOXIC EFFECTS :
   Peripheral Nerve and Sensation - spastic paralysis with or without sensory
   change
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 119,541,1957

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 170 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 58,337,1936

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 2500 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 58,337,1936

TYPE OF TEST

Warnings IRRITANT
Precautionary statements
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服，清洗后方可重新使用
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适，呼叫解毒中心或医生/医师。
  • P332+P313
  • P305+P351+P338+P337+P313
  • P305+P351+P338
  • P302+P350
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P337+P313
  • P302+P352+P332+P313+P362+P364
    RTECSFZ9800000
    Signal word Warning
    Hazard statements
    • H315 Causes skin irritation 会刺激皮肤
    • H319 Causes serious eye irritation 严重刺激眼睛
    • H335 May cause respiratory irritation 可能导致呼吸道刺激
    • H303 May be harmfully swallowed 吞食可能有害
      Hazard Codes Xi
      WGK Germany2
      Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves
      Safety Statements
      • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
      • S60 This material and its container must be disposed of as hazardous waste 该物质及其容器必须作为危险废物处置；
      • S37 Wear suitable gloves 戴适当手套；
      • S37/39 Wear suitable gloves and eye/face protection 穿戴适当的手套和眼睛/面保护；
        Risk Statements
        • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
          Storage condition 极易吸潮Hygroscopic 充氩保存 0-6°C Hygroscopic
        • 内在的神经递质。
        • {MCE} [2]. A Young, et al. Diarrhoea of famine and malnutrition--investigations using a rat model. 2--Ileal hypersecretion induced by starvation. Gut. 1990 Feb;31(2):162-9.
        • {MCE} [3]. Xia Lei, et al. Effects of acetylcholine chloride on intracellular calcium concentration of cultured sweat gland epithelial cells. Arch Dermatol Res. 2008 Aug;300(7):335-41.
        • {MCE} [4]. P F Zabrodskii, et al. Effect of acetylcholine on mortality of mice from sepsis and proinflammatory cytokine production. Bull Exp Biol Med. 2011 Jan;150(3):340-2.
        • {MCE} [5]. Zhaolin Chen, et al. Inhibition of p53 Mutant Peptide Aggregation In Vitro by Cationic Osmolyte Acetylcholine Chloride. Protein Pept Lett. 2017;24(4):353-357.
        • {SA} Aldrich MSDS 1 , 19:B / Corp MSDS 1 (1), 35:D / FT-IR 1 (1), 678:C / FT-IR 2 (1), 1130:A / FT-NMR 1 (1), 1078:A / IR-Spectra (2), 350:H / IR-Spectra (3), 396:E / RegBook 1 (1), 773:H / Sax 6 , 96 / Sigma FT-IR 1 (2), 1:C / Structure Index 1 ,
          • 60-31-1 H53173 Acetylcholine chloride 氯化乙酰胆碱

          化学属性

          Mol. FormulaC7H16ClNO2
          Mol. Weight182
          Melting Point149.0 to 153.0 deg-C
          TSCAYes
          Density0.714
          Stability易吸潮
          Appearance 白色结晶性粉末，极易吸湿，微氨臭，极咸。Mp149-152℃。10%的水溶液pH值约为5，在热水和碱性溶液易分解。本品易溶于水、乙醇和丙二醇，溶于氯仿和醋酸，不溶于乙醚。低毒，LD 50 (大鼠，经口)2500 mg/kg。
          SolubilitySoluble in water (600 g/l at 20 °C), alcohol, DMSO (36 mg/ml at 25 °C), and ethanol (36 mg/ml at 25 °C). Insoluble in ether.

          *以上化合物性质及应用等信息仅供参考