Chemical Name | Triisopropylsilyl chloride |
MDL Number | MFCD00009656 |
Synonym |
Chlorotriisopropylsilane, 97+%
Chlorotriisopropylsilane, Triisopropylsilyl chloride
TIPSCI
TIPSCl
TRIISOPROPYLSILYL CHLORIDE
Triisopropylsilyl chloride Chlorotriisopropylsilane
三异丙基氯甲硅烷 |
CAS Number | 13154-24-0 |
Beilstein Registry Number | 1737446 |
PubChem Substance ID | 87576875 |
EC Number | 250-023-7 |
Alfabeta Name | TRIISOPROPYLSILYLCHLORIDE |
Reaxys-RN | 1737446 |
Chemical Name Translation | 三异丙基氯硅烷 |
InChIKey | KQIADDMXRMTWHZ-UHFFFAOYSA-N |
LabNetwork Molecule ID | LN00007870 |
Packing Group | II |
UN Number |
2987
UN 2987 8/PG 2
UN2987 |
Risk Statements | |
|
Safety Statements | |
- S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后,立即用大量水冲洗并征求医生意见;
- S27 Take off immediately all contaminated clothing 立即脱掉全部污染的衣服;
- S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护;
- S36/39 Wear suitable protective clothing and eye/face protection 穿戴适当的防护服和眼睛/面保护;
|
Storage condition |
Moisture Sensitive |
GHS Symbol
WGK Germany | 3 |
Hazard statements | |
- H227 Combustible liquid 可燃液体
- H314 Causes severe skin burns and eye damage 导致严重的皮肤灼伤和眼睛损伤
|
Personal Protective Equipment |
Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
Precautionary statements | |
- P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking. 远离热源/火花/明火/热的表面。——禁止吸烟。
- P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
- P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
- P304+P340
- P305+P351+P338
- P305+P351+P338+P310
- P310 Immediately call a POISON CENTER or doctor/physician. 立即呼救解毒中心或医生/医师。
- P370+P378
- P501 Dispose of contents/container to..… 处理内容物/容器.....
|
Signal word |
Danger |
Hazard Codes |
8
C |
Warnings |
IRRITANT |
Hazard Class | 8 |
RTECS | MB9865000 |
{ALF} For a comprehensive review of the TIPS group in organic chemistry, see: Chem. Rev., 95, 1009 (1995). See also Triisopropyl­silyl­ trifluoromethanesulfonate, B21127.
{ALF} Cleavage is usually accomplished by treatment with F-: J. Org. Chem., 51, 4941 (1986); see Tetra-n-butyl­ammonium fluoride, A10588. Alternative methods include dilute HCl: Tetrahedron Lett., 2865 (1974), or 80% AcOH: J. Carbohydr., Nucleosides, Nucleotides, 3, 197 (1976).
{ALF} Reagent for the protection of alcohols as triisopropylsilyl (TIPS) ethers. See Appendix 4. Methods of introduction include imidazole in DMF: Tetrahedron Lett., 2865 (1974), or imidazole/DMAP: Chem. Lett., 41 (1987). Also useful for N-protection. The steric bulk of TIPS makes it useful as a regio- and stereodirecting group, allowing selective protection of primary hydroxyl in the presence of secondary: Tetrahedron Lett., 2865 (1974). TIPS ethers are more resistant to acidic hydrolysis than TBDMS ethers, but less so than tert-butyldiphenylsilyl (TBDPS) ethers. However, they are more resistant to basic hydrolysis than either TBDMS or TBDPS derivatives: J. Org. Chem., 45, 4797 (1980); 49, 3239 (1984); Tetrahedron Lett., 24, 3455 (1983).