Chemical Name | 1,4-Diazabicyclo[2.2.2]octane |
Synonym |
1,4-Diazabicyclo[2.2.2]octane
{LY} 1,4-Diazabicyclo[2.2.2]octane
1,4-diazabicyclo(2.2.2)octane
1,4-diazabicyclo-octane
DABCO
DABCO cpd
triethylenediamine
triethylenediamine diacetate
{} {LY} 1,4-Diazabicyclo[2.2.2]octane
{} {} {LY} 1,4-Diazabicyclo[2.2.2]octane
{} {} {} {LY} 1,4-Diazabicyclo[2.2.2]octane
{} {} {} {} {LY} 1,4-Diazabicyclo[2.2.2]octane
{} {} {} {} {} {}
{} {} {} {} {} {} {LY} 1,4-Diazabicyclo[2.2.2]octane
{} {} {} {} {} {} {} {LY} 1,4-Diazabicyclo[2.2.2]octane
{} {} {} {} {} {} {} {} {LY} 1,4-Diazabicyclo[2.2.2]octane
{} {} {} {} {} {} {} {} {} {LY} 1,4-Diazabicyclo[2.2.2]octane
{} {} {} {} {} {} {} {} {} {} {LY} 1,4-Diazabicyclo[2.2.2]octane
{} {} {} {} {} {} {} {} {} {} {} {LY} 1,4-Diazabicyclo[2.2.2]octane
{} {} {} {} {} {} {} {} {} {} {} {}
{} {} {} {} {} {} {} {} {} {} {} {} {LY} 1,4-Diazabicyclo[2.2.2]octane
{} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 1,4-Diazabicyclo[2.2.2]octa |
MDL Number | MFCD00006689 |
CAS Number | 280-57-9 |
EC Number | 205-999-9 |
Beilstein Registry Number | 103618 |
PubChem Substance ID | 9237 |
Reaxys-RN | 103618 |
Merck Number | 9669 |
Chemical Name Translation | 三乙烯二胺 |
LabNetwork Molecule ID | LN00005644 |
InChI | InChI=1S/C6H12N2/c1-2-8-5-3-7(1)4-6-8/h1-6H2 |
Canonical SMILES | N1(CC2)CCN2CC1 |
Signal word |
Danger |
GHS Symbol
WGK Germany | 1 |
Safety Statements | |
- S16 Keep away from sources of ignition - No smoking 远离火源,禁止吸烟;
- S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后,立即用大量水冲洗并征求医生意见;
- S3 Keep in a cool place 保存在阴凉处;
- S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护;
- S37/39 Wear suitable gloves and eye/face protection 穿戴适当的手套和眼睛/面保护;
- S60 This material and its container must be disposed of as hazardous waste 该物质及其容器必须作为危险废物处置;
- S61 Avoid release to the environment. Refer to special instructions/safety data sheet 避免释放到环境中,参考特别指示/安全收据说明书;
|
Risk Statements | |
- R11 Highly flammable 非常易燃
- R22 Harmful if swallowed 吞咽有害
- R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
- R52/53
|
Precautionary statements | |
- P201 Obtain special instructions before use. 使用前获取专门指示。
- P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前,切勿操作。
- P203
- P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking. 远离热源/火花/明火/热的表面。——禁止吸烟。
- P240 Ground/bond container and receiving equipment. 与地面接触/连接集装箱和接受设备。
- P241 Use explosion-proof electrical/ventilating/lighting/…/equipment. 使用防爆电气/通风/照明/ .../设备。
- P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
- P264+P265
- P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西,喝水或吸烟。
- P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
- P273 Avoid release to the environment. 避免释放到环境中。
- P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
- P281 Use personal protective equipment as required. 使用所需的个人防护装备。
- P301+P312
- P301+P317
- P301+P330+P331+P310
- P302+P352
- P303+P361+P353+P310+P363
- P304+P340
- P304+P340+P310
- P305+P351+P338
- P305+P351+P338+P310
- P305+P354+P338
- P308+P313
- P308+P316
- P309+P311
- P310 Immediately call a POISON CENTER or doctor/physician. 立即呼救解毒中心或医生/医师。
- P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适,呼叫解毒中心或医生/医师。
- P314 Get medical advice/attention if you feel unwell. 获取医疗咨询/就医,如果你觉得不舒服
- P317
- P318
- P319
- P321 Specific treatment (see … on this label). 具体治疗(见本标签上的)。
- P330 Rinse mouth. 漱口
- P332+P313
- P332+P317
- P337+P313
- P337+P317
- P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服,清洗后方可重新使用
- P362+P364
- P370+P378
- P403+P233
- P405 Store locked up. 上锁保管。
- P501 Dispose of contents/container to..… 处理内容物/容器.....
|
Hazard statements | |
- H228 Flammable solid 易燃固体
- H302 Harmful if swallowed 吞食有害
- H315 Causes skin irritation 会刺激皮肤
- H318 Causes serious eye damage 严重伤害眼睛
- H319 Causes serious eye irritation 严重刺激眼睛
- H335 May cause respiratory irritation 可能导致呼吸道刺激
- H412 Harmfutoaquaticlifewithlonglastingeffects 对水生生物有害并具有长期影响。
|
Hazard Codes |
4.1
F,Xn |
Personal Protective Equipment |
Eyeshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
RTECS | HM0354200 |
UN Number |
1325
3263
UN1325 |
Storage condition |
2-8°C, protect from light, stored under nitrogen
{LY} 2-8°C, protect from light, stored under nitrogen
Hygroscopic
{} {LY} 2-8°C, protect from light, stored under nitrogen
{} {} {LY} 2-8°C, protect from light, stored under nitrogen
{} {} {} {LY} 2-8°C, protect from light, stored under nitrogen
{} {} {} {} {LY} 2-8°C, protect from light, stored under nitrogen
{} {} {} {} {} {LY} 2-8°C, protect from light, stored under nitrogen
{} {} {} {} {} {} {LY} 2-8°C, protect from light, stored under nitrogen
{} {} {} {} {} {} {} {LY} 2-8°C, protect from light, stored under nitrogen
{} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light, stored under nitrogen
{} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light, stored under nitrogen
{} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light, stored under nitrogen
{} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light, stored under nitrogen
{} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light |
Packing Group | II |
Hazard Class | 8 |
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - guinea pig
DOSE/DURATION : 2250 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - muscle weakness
Behavioral - muscle contraction or spasticity
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
Volume(issue)/page/year: 45(5),67,1980
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 1700 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ZHYGAM Zeitschrift fuer die Gesamte Hygiene und Ihre Grenzgebiete. (VEB
Verlag Volk und Gesundheit, Neue Gruenstr. 18, Berlin DDR-1020, Ger. Dem.
Rep.) V.1- 1955- Volume(issue)/page/year: 20,393,1974
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 1100 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - muscle weakness
Behavioral - muscle contraction or spasticity
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
Volume(issue)/page/year: 45(5),67,1980
An anti-fade reagent shown to scavenge free-radicals due to flurochrome excitation.
{uni_hamburg} Short: II/25D
{ALD} Merck: 14,9669
{ALD} Merck: 14,9669
Beilstein: 23,V,3,487
{ALF} In conjunction with palladium acetate and PEG-400 provides a reusable catalyst system for the Suzuki-Miyaura cross-coupling reaction of boronic acids: J. Org. Chem., 70, 5409 (2005).
{ALF} Forms a stable crystalline complex with H2O2, useful as an equivalent to "anhydrous" H2O2: reaction with TMS chloride gives bis(TMS) peroxide, a useful OH+-equivalent, e.g. in the conversion of aryllithiums to phenols: Synthesis, 633 (1986).
{ALF} Forms crystalline complexes with organolithium compounds: J. Am. Chem. Soc., 87, 3276 (1965), which show enhanced reactivity, e.g. in the high yield ɑ-metallation of thioanisole by n-BuLi: J. Org. Chem., 31, 4097 (1966).
{ALF} Dabco is a registered trademark of Air Products and Chemicals Inc.
{ALF} For further illustrative example, see: Org. Synth., 75, 106 (1997). Complete reaction often takes several days at ambient temperature, while heating causes lower yields. However, it is greatly accelerated by microwave irradiation: Synlett, 444 (1994). Superior results with reduced reaction times can be achieved in aqueous medium: J. Org. Chem., 66, 5413 (2001). The use as reaction medium of tetramethylene sulfone: Tetrahedron Lett., 45, 1183 (2004), or PEG-400: Tetrahedron Lett., 45, 5865 (2004) has also been advocated. Lithium perchlorate was found to increase the reaction rate dramatically: Tetrahedron Lett., 40, 1539 (1999), as was a catalytic amount of a metal triflate, particularly La or Sm; conventional Lewis acids were ineffective: J. Org Chem., 63, 7183 (1998). For asymmetric Baylis-Hillman reaction using (1S,2R)-(-)-10,2-Camphorsultam, A15897, as chiral auxiliary, see: J. Am. Chem. Soc., 119. 4317 (1997). See also 3-Quinuclidinol, B21503. For more recent discussion and comparison of different catalysts, see: J. Org. Chem., 692 (2003). In a reinterpretaion of the mechanism, a hemiacetal interemediate has been proposed: J.
{uni_ha