(S)-(-)-2-Methyl-CBS-oxazaborolidine (S)-(-)-2-甲基-CBS-噁唑硼烷

规格: 1.0 M solution in toluene, SpcSeal
CAS: 112022-81-8
产品编号: H68988
MDL: MFCD00078439
品牌: INFI
Chemical Name(S)-3,3-Diphenyl-1-Methyltetrahydro-1H,3H-Pyrrolo[1,2-c][1,3,2]Oxazaborole
Synonym ALPHA,ALPHA-DIPHENYL-L-PROLINOL METHYLBORONIC ACID CYCL-AMIDE ESTER (S)-2-METHYL-CBS-OXAZABOROLIDINE, 1M IN& (S)-ME CBS (S)-3,3-DIPHENYL-1-METHYLTETRAHYDRO-3H-PYRROLO-[1,2-C][1,3,2]OXAZABOROLE (S)--2-甲基-CBS-氧杂硼啶 (s)-methyloxazaborolidine,(s)-mecbs,intoluene (s)-methyloxazaborolidine,(s)-mecbs,in (S)-Methyl oxazaborolidine, in toluene, 1M solution (S)-3,3-Diphenyl-1-methylpyrrolidino[1,2-c]-1,3,2-oxazaborole (S)-Methyloxazaborolidine,1-1.5Mintoluene[(S)-MeCBS] (S)-5,5-DIPHENYL-2-METHYL-3,4-PROPANO-1,3,2-OXAZABOROLIDINE (S)-甲基恶唑硼烷 (S)-1-METHYL-3,3-DIPHENYL-TETRAHYDRO-PYRROLO[1,2C][1,3,2]OXAZABOROLE (S)-2-METHYL-CBS-OXAZABOROLIDINE, 1M SOL UTION IN TOLUENE (S)-3,3-DIPHENYL-1-METHYLTETRAHYDRO-3H-P YRROLO-OXAZABOROLE (S)-5,5-联苯-2-甲基-3,4-丙醇-1,3,2-恶唑硼烷 (s)-methyl (S)-2-甲基-CBS-恶唑硼烷 (S)-2-甲基-CBS-氧杂硼啶单水合物 (S)-(-)-2-METHYL-CBS-OXAZABOROLIDINE (S)--2-甲基-CBS-氧杂硼啶, 1M 甲苯溶液 (S)-(-)-2-甲基-CBS-噁唑硼烷 溶液 (S)-(+)-甲基-CBS-恶唑硼烷 (S)-METHYL OXAZABOROLIDINE (S)-2-METHYL-CBS-OXAZABOROLIDINE MONOHYDRATE (S)-3,3-DIPHENYL-1-METHYLTETRAHYDRO-1H,3H-PYRROLO[1,2-C][1,3,2]OXAZABOROLE (S)-(-)-2-甲基-CBS-噁唑硼烷 (S)-TETRAHYDRO-1-METHYL-3,3-DIPHENYL-1H,3H PYRROLO[1,2-C][1,3,2] OXAZABOROLE (S)-2-METHYL-CBS-OXAZABOROLIDINE α,α-二苯基-L-脯氨醇甲基硼酸环胺酯 (S)-3,3-二苯基-1-甲基四氢-3H-吡咯并[1,2-c][1,3,2]噁唑硼烷 (S)-四氢-1-甲基-3,3-二苯基-1H,3H-吡咯并[1,2-c][1,3,2]噁唑硼烷 (S)-1-甲基-3,3-二苯基-四氢-吡咯并[1,2c][1,3,2]噁唑硼烷
PubChem Substance ID2734713
Beilstein Registry Number8492123
EC Number250-023-7
Reaxys-RN8492123
Chemical Name Translation(S)-2-甲基-CBS-恶唑硼烷
InChIInChI=1S/C18H20BNO/c1-19-20-14-8-13-17(20)18(21-19,15-9-4-2-5-10-15)16-11-6-3-7-12-16/h2-7,9-12,17H,8,13-14H2,1H3/t17-/m0/s1
LabNetwork Molecule IDLN00162856
MDL NumberMFCD00078439
CAS Number112022-81-8
GHS Symbol
Precautionary statements
    Hazard statements
    • H315 Causes skin irritation 会刺激皮肤
    • H319 Causes serious eye irritation 严重刺激眼睛
    • H335 May cause respiratory irritation 可能导致呼吸道刺激
    • H304 May be fatal if swallowed and enters airways 吞食和进入呼吸道可能致命
    • H336 May cause drowsiness or dizziness 肯能导致嗜睡或头晕
    • H225 Highly flammable liquid and vapour 高度易燃液体和蒸气
    • H361d Suspected of damaging the unborn child 怀疑对未出生婴儿造成伤害
    • H373 May causes damage to organs through prolonged or repeated exposure 长期或频繁接触可能会损伤器官
    • H351 Suspected of causing cancer 怀疑致癌
      WGK Germany3
      Signal word
      Personal Protective Equipment Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter dust mask type N95 (US), Eyeshields, Gloves
      Safety Statements
      • S46 If swallowed, seek medical advice immediately and show this container or label 食入时，立即求医并出示容器/标签；
      • S62 If swallowed, do not induce vomiting: seek medical advice immediately and show this container or label where possible 吞食后不要催吐：立即求医并出示该容器或标签；
      • S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；
      • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
      • S16 Keep away from sources of ignition - No smoking 远离火源，禁止吸烟；
      • S33 Take precautionary measures against static discharges 对静电采取预防措施；
      • S29 Do not empty into drains 不要排入下水道；
      • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
        Packing GroupII
        UN Number
        Risk Statements
        • R11 Highly flammable 非常易燃
        • R19 May form explosive peroxides 可能生成易爆的过氧化物质
        • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
          Storage condition 0-10 Air & Moisture Sensitive 0-10°C Refrigerator
          Hazard Codes
          Hazard Class3
        • {ALF} For reviews of oxazaborolidines as enantioselective catalysts, see: Angew. Chem. Int. Ed., 31, 729 (1992); 37, 1986 (1998); Tetrahedron: Asymmetry, 3, 1475 (1992).
        • {ALF} Catalyst for the CBS (Corey, Bakshi, Shibata) reduction of prochiral ketones with borane-THF, with high enantioselectivity (see (S)-(-)-ɑ,ɑ-Diphenyl­prolinol, L09217): J. Am . Chem. Soc., 109, 7925 (1987):
        • {ALF}
        • {ALF} For successful use of this system in a scaled up asymmetric synthesis of the antiarrythmia agent d-Sotalol, see: Org. Process Res. Dev., 1. 176 (1997). For use in enantioselective reduction of ketones containing heteroatoms, see: Tetrahedron Lett., 34, 785 (1993). For the asymmetric reduction of ɑ-ketoimines, see: Tetrahedron Lett., 35, 5551 (1994).
        • {ALF} Air-stable solid prepared by a modification of Corey's procedure, on which his literature results were based. For anhydrous reagent, see (S)-2-Methyl-CBS-oxazaborolidine, L14583.
        • {ALF} For reviews of the asymmetric reduction of ketones, see: Synthesis, 605 (1992); Chem. Ind. (London), 552 (1994).
        • {ALF} Anhydrous catalyst for 'CBS' reduction reaction. For examples of use in asymmetric reduction of ketones, see: Org. Synth. Coll., 9, 362, 676 (1998). For further information, see (S)-2-Methyl-CBS-oxazaborolidine monohydrate, L09219.
          • 112022-81-8 H68988 (S)-(-)-2-Methyl-CBS-oxazaborolidine (S)-(-)-2-甲基-CBS-噁唑硼烷

          化学属性

          Boiling Point111
          TSCANo
          Melting Point87-91
          Refractive indexn20/D 1.460
          Mol. FormulaC18H20BNO
          Mol. Weight277.17
          Density0.925
          Flash Point40°F (toluene)
          Appearance liq.
          Stabilitymoisture sensitive

          *以上化合物性质及应用等信息仅供参考