| Chemical Name | Triethyl Orthoformate |
|---|
| Synonym |
1
1'
1''(次甲基三(氧代))三乙烷
1,1,1-TRIETHOXYMETHANE
1,1,1-triethoxy-methane
1,1’,1’’(次甲基三(氧代))三乙烷
AETHON
Aethon
Ethyl Orthoformate
Ethyl Orthoformate, 1,1,1-Triethoxymethane
Ethyl formate(ortho)
Ethyl orthoformate
Ethyl orthoformate; Triethoxymethane
Ethylester kyseliny orthomravenci
Methane, triethoxy-
Orthoameisensäuretriethylester
Orthomravencan ethylnaty
TEOF
Triethoxymethane
Triethyl orthoformate
Triethylester kyseliny orthomravenci
diethoxymethoxy-ethane
triethoxy methane
{} {} {} {} {} {} {} {} {} {} {} {} {} {} {Che
三乙基原甲酸酯
三乙氧基甲烷
三乙氧甲烷
原甲酸三乙酯
原甲酸乙酯,三乙氧基甲烷, 1,1',1''(次甲基三(氧代))三乙烷
正甲酸三乙酯 |
| CAS Number | 122-51-0 |
|---|
| PubChem Substance ID | 31214 |
|---|
| EC Number | 204-550-4 |
|---|
| Beilstein Registry Number | 605384 |
|---|
| MDL Number | MFCD00009230 |
|---|
| Reaxys-RN | 605384 |
|---|
| Merck Number | 6884 |
|---|
| Chemical Name Translation | 原甲酸三乙酯 |
|---|
| Wiswesser Line Notation | 2OYO2&O2 |
|---|
| LabNetwork Molecule ID | LN00164395 |
|---|
| InChI | InChI=1S/C7H16O3/c1-4-8-7(9-5-2)10-6-3/h7H,4-6H2,1-3H3 |
|---|
GHS Symbol
| WGK Germany | 1 |
|---|
| Hazard statements | |
|---|
- H226 Flammable liquid and vapour 易燃液体和蒸气
|
| Personal Protective Equipment |
Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
| Hazard Codes |
3
Xi |
| RTECS | RM6475000 |
|---|
| Signal word |
Warning |
| Safety Statements | |
|---|
- S16 Keep away from sources of ignition - No smoking 远离火源，禁止吸烟；
- S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
- S36/39 Wear suitable protective clothing and eye/face protection 穿戴适当的防护服和眼睛/面保护；
- S37 Wear suitable gloves 戴适当手套；
- S37/39 Wear suitable gloves and eye/face protection 穿戴适当的手套和眼睛/面保护；
- S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
- S60 This material and its container must be disposed of as hazardous waste 该物质及其容器必须作为危险废物处置；
|
| Risk Statements | |
|---|
- R10 Flammable 易燃
- R36 Irritating to eyes 刺激眼睛
- R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
|
| Precautionary statements | |
|---|
- P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking. 远离热源/火花/明火/热的表面。——禁止吸烟。
- P233 Keep container tightly closed. ?保持容器密闭。
- P240 Ground/bond container and receiving equipment. 与地面接触/连接集装箱和接受设备。
- P241+P242+P243
- P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
- P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
- P302+P352+P332+P313+P362+P364
- P305+P351+P338
- P305+P351+P338+P337+P313
- P332+P313
- P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服，清洗后方可重新使用
- P370+P378
- P403+P235
- P501 Dispose of contents/container to..… 处理内容物/容器.....
|
| UN Number |
2524 |
| Storage condition |
Moisture Sensitive
对湿敏感
Flammables area
充氩保存 |
| Packing Group | III |
|---|
| Hazard Class | 3 |
|---|
| Warnings |
危化品目录(2015) |
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Rodent - guinea pig
DOSE/DURATION : >10 mL/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For
publisher information, see FCTOD7. Volume(issue)/page/year: 17,917,1979
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 7060 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine.
(Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU.
Volume(issue)/page/year: 4,119,1951
TYPE OF TEST : LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 4000 ppm/8H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine.
(Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU.
Volume(issue)/page/year: 4,119,1951
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 20 mL/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine.
(Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU.
Volume(issue)/page/year: 4,119,1951
| Restrict |
危险品 |
A reagent useful for acetylization and imidic ester formation.
{uni_hamburg} Short: III/35E
{ALF} In the presence of BF3 etherate, is a source of the diethoxycarbenium ion: Synth. Commun., 19, 2307 (1989), a selective alkylating agent and a useful intermediate for the diethoxymethylenation of ketones, to give protected ß-ketoaldehydes: J. Org. Chem., 46, 2557 (1981). For a similar reaction with enamines to give the same products, see: Chem. Lett., 1307 (1982); Bull. Chem. Soc. Jpn., 57, 1876 (1984).
{ALF} Orthoformates have also found use in the electrophilic formylation of activated aromatic species, e.g.: phenols (in the presence of AlCl3): Chem. Ber., 96, 308 (1963); pyrrole derivatives (with TFA): Austral. J. Chem., 25, 1979 (1972).
{uni_hamburg} Short: III/38B
{ALF} Acid-catalyzed reaction with an arylamine gives the N-ethoxymethylene derivative (imidic ester); see, e.g.: Org. Synth. Coll., 4, 464 (1963); reduction (NaBH4) gives the monomethyl amine: Synthesis, 55 (1974).
{ALF} For further reactions of alkyl orthoformates, see Trimethyl­ orthoformate, A13760.
{ALD} Merck: 14,6884
Beilstein:2,20
{ALD} Merck: 14,6884
{ALF} Due to their intrinsic dehydrating property, orthoformates are convenient reagents for acetalization of carbonyl compounds, under acid catalysis, e.g. tosic acid: J. Am. Chem. Soc., 60, 1905 (1938); J. Org. Chem., 20, 1695 (1955), or acidic ion-exchange resin: Synthesis, 348 (1974). Selective catalysis with NBS has been found to give high yields of acetals under almost neutral conditions: Synlett, 1456 (1999).
