Dichloromethane 二氯甲烷

规格: 99.9%, SpcDry, with molecular sieves, Water≤50 ppm (by K.F.)
CAS: 75-09-2
产品编号: H74956
MDL: MFCD00000881
品牌: INFI
Chemical NameDichloromethane
Synonym Aerothene MM CH2Cl2 (dichloro-methane) Dichlormethan Dichloromethane F 30 (chlorocarbon) Methane dichloride Methylenchlorid Methylene bichloride Methylene chloride Methylene dichloride R 30 R 30 (refrigerant) R-30 R30 (refrigerant) Solaesthin Solmethine dichloromethane methylene chloride 二氯甲烷 亚甲基氯 溶液 甲叉二氯,氯化次甲基,亚甲基二氯,亚甲基氯,甲撑氯
CAS Number75-09-2
PubChem Substance ID6344
EC Number200-838-9
Beilstein Registry Number1730800
MDL NumberMFCD00000881
Reaxys-RN1730800
Merck Number14,6063
Chemical Name Translation二氯甲烷(易涉毒)
Wiswesser Line NotationG1G
LabNetwork Molecule IDLN00162825
InChIInChI=1S/CH2Cl2/c2-1-3/h1H2
GHS Symbol
TYPE OF TEST            : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 2000 ppm/5H/2Y-C
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Lungs, Thorax, or Respiration - tumors
REFERENCE :
   NTPTR* National Toxicology Program Technical Report Series.  (Research
   Triangle Park, NC 27709) No.206-  Volume(issue)/page/year: NTP-TR-306,1986

TYPE OF TEST            : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 3500 ppm/6H/2Y-I
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Endocrine - tumors
REFERENCE :
   FAATDF Fundamental and Applied Toxicology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1981-  Volume(issue)/page/year:
   4,30,1984

TYPE OF TEST            : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Human
DOSE/DURATION           : 500 ppm/8H
TOXIC EFFECTS :
   Behavioral - euphoria
REFERENCE :
   SCIEAS Science.  (American Assoc. for the Advancement of Science, 1333 H
   St., NW, Washington, DC 20005)  V.1-    1895-  Volume(issue)/page/year:
   176,295,1972

TYPE OF TEST            : LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 14400 ppm/7H
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NIHBAZ National Institutes of Health, Bulletin.  (Bethesda, MD)
   Volume(issue)/page/year: 191,1,1949

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intratracheal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 350 mg/kg
TOXIC EFF

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 2700 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   QJPPAL Quarterly Journal of Pharmacy & Pharmacology.  (London, UK)  V.2-21,
   1929-48.  For publisher information, see JPPMAB.  Volume(issue)/page/year:
   7,205,1934

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 200 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   QJPPAL Quarterly Journal of Pharmacy & Pharmacology.  (London, UK)  V.2-21,
   1929-48.  For publisher information, see JPPMAB.  Volume(issue)/page/year:
   7,205,1934

TYPE OF TE

TYPE OF TEST            : DNA damage
TEST SYSTEM             : Rodent - hamster Ovary
DOSE/DURATION           : 3000 ppm
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 367,143,1996

TYPE OF TEST            : DNA inhibition
TEST SYSTEM             : Rodent - hamster Lung
DOSE/DURATION           : 5000 ppm/1H (Continuous)
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE

TYPE OF TEST            : DNA damage
ROUTE OF EXPOSURE       : Inhalation
TEST SYSTEM             : Rodent - mouse
DOSE/DURATION           : 4000 ppm/6H (Continuous)
REFERENCE :
   CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
   Southfield Road, Eynsham, Oxford OX8 1JJ, UK)  V.1-    1980-
   Volume(issue)/page/year: 15,991,1994

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 6300 ppm
REFERENCE :
   EMMUEG Environmental and Molecular Mutagenesis.  (Alan R. Liss, Inc., 41 E.
   11th St., New York, NY 10003)  V.10-    1987-  Volume(issue)/page/year:
   20,211,1992

TYPE OF TEST            : Sister chromatid exchange
ROUTE OF EXPOSURE       : Inhalation
TEST SYSTEM             : Rodent - mouse
DOSE/DURATION           : 13880 mg/m3/6H/2W (Intermittent)
REFERENCE :
   EMMUEG Environmental and Molecular Mutagenesis.  (Alan R. Liss, Inc., 41 E.
   11th St., New York, NY 10003)  V.10-    1987-  Volume(issue)/page/year:
   15,221,1990

TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Rodent - hamster Ovary
DOSE/DURATION           : 6628 mg/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 116,361,1983

TYPE

TYPE OF TEST            : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 1250 ppm/7H
SEX/DURATION            : female 6-15 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   32,84,1975

TYPE OF TEST            : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 1250 ppm/7H
SEX/DURATION            : female 6-15 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - musculoskeletal system
   Reproductive - Specific Developmental Abnormalities - urogenital system
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   32,84,1975

TYPE OF TEST            : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 4500 ppm/24H
SEX/DURATION            : female 1-17 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Newborn - behavioral
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   52,29,1980

WGK Germany2
Hazard Codes 6.1 C,N Xn
Hazard statements
  • H351 Suspected of causing cancer 怀疑致癌
  • H302 Harmful if swallowed 吞食有害
  • H371 May cause damage to organs 可能导致器官损伤
  • H314 Causes severe skin burns and eye damage 导致严重的皮肤灼伤和眼睛损伤
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
  • H400 Verytoxictoaquaticlife 对水生生物毒性非常大。
  • H225 Highly flammable liquid and vapour 高度易燃液体和蒸气
  • H315 Causes skin irritation 会刺激皮肤
  • H336 May cause drowsiness or dizziness 肯能导致嗜睡或头晕
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H373 May causes damage to organs through prolonged or repeated exposure 长期或频繁接触可能会损伤器官
    Personal Protective Equipment Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US)
    RTECSPA8050000
    Precautionary statements
    • P201 Obtain special instructions before use. 使用前获取专门指示。
    • P240 Ground/bond container and receiving equipment. 与地面接触/连接集装箱和接受设备。
    • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
    • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
    • P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
    • P281 Use personal protective equipment as required. 使用所需的个人防护装备。
    • P303+P361+P353
    • P304+P340
    • P305+P351+P338
    • P308+P313
    • P501 Dispose of contents/container to..… 处理内容物/容器.....
      Signal word Danger Warning
      Safety Statements
      • S23 Do not breathe gas/fumes/vapour/spray (appropriate wording to be specified by the manufacturer) 不要吸入气体/烟雾/蒸汽/喷雾;
      • S24/25 Avoid contact with skin and eyes 避免皮肤和眼睛接触;
      • S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套;
        Risk Statements
        • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
        • R40 Limited evidence of a carcinogenic effect 有限证据表明其致癌作用
        • R67 Vapours may cause drowsiness and dizziness 蒸汽可能导致嗜睡和昏厥
          Storage condition 储存温度2-8℃ 密封避光保存。 充氩保存 0-10°C 0-10 储存温度 2-8°C ,充氩储存
          UN Number 1593 1593/1912 UN1593
          Packing GroupIII
          Hazard Class3/6.1
          Warnings 危化品目录(2015)
          Restrict -
        • {ALD} Merck: 14,6063
        • Beilstein: 1,IV,35
        • {uni_hamburg} Short: II/25B
        • {uni_hamburg} Short: II/14a
        • {ALD} Merck: 14,6063
        • {uni_hamburg} Short: II/2
        • 75-09-2 H74956 Dichloromethane
二氯甲烷

          化学属性

          Refractive indexn20/D 1.424(lit.)
          Boiling Point39-40
          Melting Point-97
          TSCAYes
          Autoignition Point1223 °F
          Vapor Density2.9 (vs air)
          Vapor Pressure24.45 psi ( 55 °C)
          Solubility20 G/L (20 ºC)
          Stability对光敏感
          Density1.305
          Mol. FormulaCH2Cl2
          Mol. Weight85.00
          Danger-Level乙类
          pH-:-
          Redox-

          *以上化合物性质及应用等信息仅供参考