Potassium tert-butoxide 叔丁醇钾

规格: 1.8 M solution in THF, SpcSeal
CAS: 865-47-4
产品编号: H86017
MDL: MFCD00012162
品牌: INFI
Chemical NamePotassium Tert-Butoxide
Synonym tert-Butanol (potassium) {LY} tert-Butanol (potassium) {} {LY} tert-Butanol (potassium) {} {} {LY} tert-Butanol (potassium) {} {} {} {LY} tert-Butanol (potassium) {} {} {} {} {LY} tert-Butanol (potassium) {} {} {} {} {} {LY} tert-Butanol (potassium) {} {} {} {} {} {} {LY} tert-Butanol (potassium) {} {} {} {} {} {} {} {LY} tert-Butanol (potassium) {} {} {} {} {} {} {} {} {LY} tert-Butanol (potassium) {} {} {} {} {} {} {} {} {} {LY} tert-Butanol (potassium) {} {} {} {} {} {} {} {} {} {} {LY} tert-Butanol (potassium) {} {} {} {} {} {} {} {} {} {} {} {LY} tert-Butanol (potassium) {} {} {} {} {} {} {} {} {} {} {} {} {LY} tert-Butanol (potassium) {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} tert-Butanol (potassium) {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} tert-Butanol (potassium) {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} tert-Butanol (potassium) {} {} {} {} {} {} {} {} {} {}
PubChem Substance ID23665647
EC Number212-740-3
Beilstein Registry Number3556712
Reaxys-RN3556712
Chemical Name Translation叔丁醇钾
InChIKeyLPNYRYFBWFDTMA-UHFFFAOYSA-N
LabNetwork Molecule IDLN00163822
InChIInChI=1S/C4H9O.K/c1-4(2,3)5;/h1-3H3;/q-1;+1
MDL NumberMFCD00012162
CAS Number865-47-4
Canonical SMILESCC(C)(O[K])C
GHS Symbol
WGK Germany1
Hazard statements
  • H225 Highly flammable liquid and vapour 高度易燃液体和蒸气
  • H228 Flammable solid 易燃固体
  • H251 Self-heating: may catch fire 自我放热：可能着火
  • H252 Self-heating in large quantities; may catch fire 自我释放大量的热；可能着火。
  • H260 In contact with water releases flammable gases which may ignite spontaneously 与水接触时释放可燃气体，可自燃。
  • H302 Harmful if swallowed 吞食有害
  • H314 Causes severe skin burns and eye damage 导致严重的皮肤灼伤和眼睛损伤
  • H318 Causes serious eye damage 严重伤害眼睛
  • H332 Harmful if inhaled 吸入有害
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
  • H351 Suspected of causing cancer 怀疑致癌
    Hazard Codes 4.2 F,C
    Precautionary statements
    • P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking. 远离热源/火花/明火/热的表面。——禁止吸烟。
    • P231+P232
    • P235 Keep cool. 保持凉爽。
    • P235+P410
    • P240 Ground/bond container and receiving equipment. 与地面接触/连接集装箱和接受设备。
    • P241 Use explosion-proof electrical/ventilating/lighting/…/equipment. 使用防爆电气/通风/照明/ .../设备。
    • P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
    • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
    • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
    • P264+P265
    • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
    • P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
    • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
    • P301+P312
    • P301+P317
    • P301+P330+P331
    • P301+P330+P331+P310
    • P302+P361+P354
    • P303+P361+P353
    • P303+P361+P353+P310+P363
    • P304+P340
    • P304+P340+P310
    • P305+P351+P338
    • P305+P351+P338+P310
    • P305+P354+P338
    • P310 Immediately call a POISON CENTER or doctor/physician. 立即呼救解毒中心或医生/医师。
    • P316
    • P317
    • P321 Specific treatment (see … on this label). 具体治疗（见本标签上的）。
    • P330 Rinse mouth. 漱口
    • P363 Wash contaminated clothing before reuse. 被污染的衣服洗净后方可重新使用。
    • P370+P378
    • P402+P404
    • P405 Store locked up. 上锁保管。
    • P407 Maintain air gap between stacks/pallets. 在堆叠/货板间保持气隙。
    • P410 Protect from sunlight. 防止阳光照射。
    • P413 Store bulk masses greater than … kg/…lbs at temperatures not exceeding … oC/…oF. 商店散装超过…kg/…lbs 时温度不应超过…oC/…oF.
    • P420 Store away from other materials. 远离其他材料。
    • P501 Dispose of contents/container to..… 处理内容物/容器.....
      Signal word Danger
      Personal Protective Equipment Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
      UN Number 3206
      Safety Statements
      • S16 Keep away from sources of ignition - No smoking 远离火源，禁止吸烟；
      • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
      • S27 Take off immediately all contaminated clothing 立即脱掉全部污染的衣服；
      • S30 Never add water to this product 切勿将水加入该产品中；
      • S33 Take precautionary measures against static discharges 对静电采取预防措施；
      • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
      • S43 In case of fire use ... (indicate in the space the precise type of fire-fighting equipment. If water increases the risk add -?Never use water) 着火时使用（指明具体的消防器材种类，如果用水增加危险，注明“禁止用水”
      • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
      • S60 This material and its container must be disposed of as hazardous waste 该物质及其容器必须作为危险废物处置；
      • S7/9 Keep container tightly closed and in a well-ventilated place 保持容器严格密闭，置于通风良好的场所；
      • S8 Keep container dry 保持容器干燥；
        Risk Statements
        • R11 Highly flammable 非常易燃
        • R14 Reacts violently with water 遇水会猛烈反应
        • R19 May form explosive peroxides 可能生成易爆的过氧化物质
        • R20 Harmful by inhalation 吸入有害
        • R22 Harmful if swallowed 吞咽有害
        • R34 Causes burns 会导致灼伤
        • R35 Causes severe burns 会导致严重灼伤
        • R37 Irritating to respiratory system 刺激呼吸道
          Storage condition Store at room temperature, keep dry and cool {LY} Store at room temperature, keep dry and cool {} {LY} Store at room temperature, keep dry and cool {} {} {LY} Store at room temperature, keep dry and cool {} {} {} {LY} Store at room temperature, keep dry and cool {} {} {} {} {LY} Store at room temperature, keep dry and cool {} {} {} {} {} { {} {} {} {} {} {LY} Store at room temperature, keep dry and cool {} {} {} {} {} {} {LY} Store at room temperature, keep dry and cool {} {} {} {} {} {} {} {LY} Store at room temperature, keep dry and cool {} {} {} {} {} {} {} {} {Chemicalbook} Flammables area {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {ALF} Air & Moisture Sensitive {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, stored under nitrogen {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, stored under nitrogen {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, stored under nitrogen {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, stored under nitrogen
          Packing GroupII
          Hazard Class4.2/8
        • Usually used for greener amidation of esters.
        • {ALF} Strong base of relatively low nucleophilicity. Review: Chem. Rev., 74, 45 (1974). The nucleophilicity is increased in the presence of 18-crown-6; the basic strength less so: J. Org. Chem., 43, 447 (1978).
        • {ALF} Deprotonation of an ɑ-halo sulfone, followed by Ramberg-Backlund reaction with extrusion of SO2, gives an alkene: J. Am. Chem. Soc., 110, 4866 (1988); Org. React., 25, 1 (1977); Org. Synth. Coll., 8, 212 (1993):
        • {ALF} For cyclization-elimination of ɑɑ-dibromoneopentyl ketone to di-tert-butylcyclopropenone, a precursor of tri-tert-butylcyclopropenium tetrafluoroborate, see: Org. Synth. Coll., 6, 991 (1988); for reaction scheme, see Neopentyl­ chloride, L02365.
        • {ALF} For intramolecular cyclization of a dinitrile to an unsaturated vic-amino nitrile (Thorpe-Ziegler reaction), see: Org. Synth. Coll., 6, 932 (1988).
        • {ALFA} Combinations of KO-t-Bu with other s
        • {ALF} Combinations of KO-t-Bu with other strong bases are used to generate "superbasic" media, e.g. with n-BuLi: J. Organomet. Chem., 8, 9 (1967); Pure Appl. Chem., 60, 1627 (1988); Tetrahedron Lett., 29, 4991 (1988); see also Phenyl­acetyl­ene, A12139, 2-Methyl­indole, A10764, etc. In combination with Li 3-aminopropanamide, promotes the "zip" reaction for isomerizing alkynes to the terminal position; see 1,3-Diaminopropane, A11932, and Org. Synth. Coll., 8, 146 (1993). For use in combination with LDA for isomerization of epoxides to allylic alcohols, see Cyclohexene oxide, A13185.
        • {ALF} Treatment of a methyl ester in ether with the reagent provides a simple method for preparation of tert-butyl esters: Synlett, 658 (2001).
        • {ALF} For generation of dibromocarbene, see Bromoform, A11904. In combination with a solid-liquid phase-transfer catalyst in the absence of solvent, has been recommended for the dehydrobromination of alkyl bromides to alkenes: J. Org. Chem., 49, 1138 (1984): with 18-crown-6, is effective for the dehydrobromination of vic-dibromides: Liebigs Ann. Chem
          • 865-47-4 H86017 Potassium tert-butoxide 叔丁醇钾

          化学属性

          Flash Point-19°(-2°F)
          TSCAYes
          Vapor Pressure1 mmHg ( 220 °C)
          Boiling Point275 °C at 760 mmHg
          Solubility起反应
          Appearance white to off-white pwdr.
          Stabilitymoisture sensitive
          Melting Point256-258 °C
          Density0.929
          Mol. FormulaC4H9KO
          Mol. Weight112.21
          Danger-Level甲类
          RedoxReduction

          *以上化合物性质及应用等信息仅供参考