研峰科技 Infinity Scientific

N,N-Dimethylacetamide N,N-二甲基乙酰胺

规格: 99%

CAS: 127-19-5

产品编号: H89073

MDL: MFCD00008686

品牌: INFI

Chemical Name	N,N-Dimethylacetamide
CAS Number	127-19-5
PubChem Substance ID	87567287
EC Number	204-826-4
Beilstein Registry Number	1737614
MDL Number	MFCD00008686
Reaxys-RN	1737614
Merck Number	3227
Synonym	N,N-Dimethylacetamide {LY} N,N-Dimethylacetamide {} {LY} N,N-Dimethylacetamide {} {} {LY} N,N-Dimethylacetamide {} {} {} {LY} N,N-Dimethylacetamide {} {} {} {} {LY} N,N-Dimethylacetamide {} {} {} {} {} {LY} N,N-Dimethylacetamide {} {} {} {} {} {} {LY} N,N-Dimethylacetamide {} {} {} {} {} {} {} {LY} N,N-Dimethylacetamide {} {} {} {} {} {} {} {} {LY} N,N-Dimethylacetamide {} {} {} {} {} {} {} {} {} {LY} N,N-Dimethylacetamide {} {} {} {} {} {} {} {} {} {} {LY} N,N-Dimethylacetamide {} {} {} {} {} {} {} {} {} {} {} {LY} N,N-Dimethylacetamide {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} N,N-Dimethylacetamide {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} N,N-Dimethylacetamide {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} N,N-Dimethylacetamide {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} N,N-Dimethylacetamide
Chemical Name Translation	N,N-二甲基乙酰胺
Wiswesser Line Notation	1VN1&1
LabNetwork Molecule ID	LN00162944
InChI	InChI=1S/C4H9NO/c1-4(6)5(2)3/h1-3H3
Canonical SMILES	CC(N(C)C)=O

GHS Symbol

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 2640 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 26,1581,1976

{haz

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >2 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   EPASR* United States Environmental Protection Agency, Office of Pesticides
   and Toxic Substances. (U.S. Environmental Protection Agency, 401 M St., SW,
   Washington, DC 20460)  History unknown.  Volume(issue)/page/year:
   8EHQ-1190-0981

TYPE OF TEST            : LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 7200 mg/m3
TOXIC EFFECTS :
   Behavioral - ataxia
   Lungs, Thorax, or Respiration - other changes
   Liver - other changes
REFERENCE :
   CHYCDW Zhonghua Yufangyixue Zazhi.  Chinese Journal of Preventive Medicine.
   (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep.
   China)  Beginning history not known.  Volume(issue)/page/year: 13,29,1979

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 4620 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulen

TYPE OF TEST            : Sister chromatid exchange
TEST SYSTEM             : Rodent - hamster Ovary
DOSE/DURATION           : 10 gm/L
REFERENCE :
   APHGAO Acta Pharmaceutica Hungarica.  (Kultura, POB 149, H-1389 Budapest,
   Hungary)  1953-    Adopts V.24 in 1955.  Volume(issue)/page/year: 56,97,1986

TYPE OF TEST            : DNA inhibition
ROUTE OF EXPOSURE       : Unreported
TEST SYSTEM             : Rodent - mouse
DOSE/DURATION           : 4400 mg/kg
REFERENCE :
   APHGAO Acta Pharmaceutica Hungarica.  (Kultura, POB 149, H-1389 Budapest,
   Hungary)  1953-    Adopts V.24 in 1955.  Volume(issue)/page/year: 56,97,1986

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 5600 mg/kg
SEX/DURATION            : female 6-19 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
   resorbed implants per total number of implants)
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
   Reproductive - Specific Developmental Abnormalities - craniofacial
   (including nose and tongue)
REFERENCE :
   FAATDF Fundamental and Applied Toxicology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1981-  Volume(issue)/page/year:
   9,550,1987

TYPE OF TEST            : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 300 ppm/6H
SEX/DURATION            : female 10 week(s) pre-mating  - 3 week(s) post-birth
TOXIC EFFECTS :
   Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight
   gain)
REFERENCE :
   FAATDF Fundamental and Applied Toxicology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1981-  Volume(issue)/page/year:
   7,132,1986

TYPE OF TEST            : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 281 ppm/6H
SEX/DURATION            : female 6-15 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
REFERENCE :
   TJADAB Teratology, The International Journal of Abnormal Development. (Alan
   R. Liss, Inc., 41 E. 11th St., New York, NY 10003)  V.1-    1968-
   Volume(issue)/page/year: 29(2),59A,1984

TYPE OF TEST            : TDLo - Lowest published toxic dos

WGK Germany	2
Hazard Codes	6.1 T
Hazard statements
H227 Combustible liquid 可燃液体 H312+H332 H319 Causes serious eye irritation 严重刺激眼睛 H360 May damage fertility or the unborn child 可能对生育能力或未出生婴儿造成伤害
Personal Protective Equipment	Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
RTECS	AB7700000
Precautionary statements
P201 Obtain special instructions before use. 使用前获取专门指示。 P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前，切勿操作。 P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking. 远离热源/火花/明火/热的表面。——禁止吸烟。 P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。 P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。 P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。 P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。 P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。 P302+P352 P304+P340 P304+P340+P312 P305+P351+P338+P337+P313 P308+P313 P332+P313 P403+P233 P405 Store locked up. 上锁保管。 P501 Dispose of contents/container to..… 处理内容物/容器.....
Signal word	Danger
Safety Statements
S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）； S53 Avoid exposure - obtain special instructions before use 避免接触，使用前获得特别指示说明；
Risk Statements
R20/21 Harmful by inhalation and in contact with skin 吸入及与皮肤接触有害 R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性 R61 May cause harm to the unborn child 可能对未出生的婴儿导致伤害
Storage condition	2-8°C {LY} 2-8°C {} {LY} 2-8°C {} {} {LY} 2-8°C {} {} {} {LY} 2-8°C {} {} {} {} {LY} 2-8°C {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {}
UN Number	2810
Packing Group	III

用于药物合成的反应溶剂，合成纤维纺丝与合成树脂的溶剂，感光化学品发色剂的溶剂，涂料等的溶剂。催化剂。

{ALF} See also Sodium hydride, 13431, for warning.

{ALD} Merck: 14,3227

{ALF} Reacts with alkyl and aryl Grignard reagents to give methyl ketones in good yields: Synthesis, 228 (1984).

{ALD} Merck: 14,3227

Beilstein:4,59

{ALF} Dipolar aprotic solvent, cf N,N-Dimethylformamide, A13547, Dimethyl sulfoxide, A13280, 1-Methyl-2-pyrrolidinone, A12260.

{ALF} Useful solvent in halex fluorinations of chloroarenes; compare Sulfolane, A13466.

{ALFA} In the presence of triflic anhydride and 2,4,6-collidine, forms a highly-reactive keteniminium triflate, which undergoes a [2+2] cycloaddition reaction with terminal alkenes to give, after hydrolysis a 3-alkylcyclobutanone: J. Am. Chem. Soc., 107, 2192 (1985); Org. Synth. Coll., 8, 306 (1993):

{ALF} Undergoes Vilsmeier-type reactions (compare DMF), with reactive substrates, introducing an acetyl group: Chem. Ber., 97, 616 (1964).

{uni_hamburg} Short: II/2

{ALF} In the presence of triflic

127-19-5 H89073 N,N-Dimethylacetamide
N,N-二甲基乙酰胺

化学属性

Mol. Formula	C4H9NO
Mol. Weight	87.12
Refractive index	1.4370 to 1.4390
Boiling Point	165.99°C at 760 mmHg
Density	0.937
Melting Point	-20 °C
Flash Point	70°C
TSCA	Yes
Autoignition Point	914 °F
Vapor Density	3 (vs air)
Vapor Pressure	2 mmHg ( 25 °C)
Solubility	MISCIBLE
Stability	对湿度敏感
pH	:A

*以上化合物性质及应用等信息仅供参考