| Chemical Name | N-Ethyldiisopropylamine |
|---|
| Synonym |
'HUNIG'S BASE'
(CH3)2CHN(C2H5)CH(CH3)2
1,1'-Dimethyltriethylamine
1,1'-Dimethyltriethylamine
2-Propanamine,N-ethyl-N-(1-methylethyl)-
Bis(1-methylethyl)ethylamine
DIEA
DIPEA
Diisopropylethylamine
HUENIG'S BASE
HUNIG'S BASE
N,N'-diisopropylethylamine
N,N-Diisopropylethylamine
N,N-Diisopropylethylamine,
N,N-Diisopropylethylamine; N-Ethyldiisopropylamine; Huenig's base; DIEA; EDIA
N,N-diisopropylethylamine
N,N-diisopropylethylamine hydrochloride
N,N-二异丙基乙胺
N,N-二异丙基乙胺/DIPEA/DIEA
N-Ethyldiisopropylamine
N-ethyldiisopropylamine
N-乙基二异丙基胺
N-乙基二异丙胺
N-乙基二异丙胺 DIPEA `Hünig's base' 二异丙基乙胺
N-乙基二异丙胺 溶液
NEthyldiisopropylamine
N，N-二异丙基乙胺
{} |
| MDL Number | MFCD00008868 |
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| CAS Number | 7087-68-5 |
|---|
| EC Number | 230-392-0 |
|---|
| Beilstein Registry Number | 605301 |
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| PubChem Substance ID | 87568082 |
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| Chemical Name Translation | N-乙基二异丙胺 |
|---|
| Reaxys-RN | 605301 |
|---|
| LabNetwork Molecule ID | LN00194060 |
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| InChI | InChI=1S/C8H19N/c1-6-9(7(2)3)8(4)5/h7-8H,6H2,1-5H3 |
|---|
| Signal word |
Danger |
GHS Symbol
| WGK Germany | 2 |
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| Safety Statements | |
|---|
- S16 Keep away from sources of ignition - No smoking 远离火源，禁止吸烟；
- S20 When using do not eat or drink 使用时，不得进食，饮水；
- S23 Do not breathe gas/fumes/vapour/spray (appropriate wording to be specified by the manufacturer) 不要吸入气体/烟雾/蒸汽/喷雾；
- S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
- S27 Take off immediately all contaminated clothing 立即脱掉全部污染的衣服；
- S33 Take precautionary measures against static discharges 对静电采取预防措施；
- S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
- S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
- S53 Avoid exposure - obtain special instructions before use 避免接触，使用前获得特别指示说明；
- S60 This material and its container must be disposed of as hazardous waste 该物质及其容器必须作为危险废物处置；
- S61 Avoid release to the environment. Refer to special instructions/safety data sheet 避免释放到环境中，参考特别指示/安全收据说明书；
- S9 Keep container in a well-ventilated place 保持容器在通风良好的场所；
|
| Risk Statements | |
|---|
- R10 Flammable 易燃
- R11 Highly flammable 非常易燃
- R20/21/22 Harmful by inhalation, in contact with skin and if swallowed 吸入、皮肤接触和不慎吞咽有害
- R22 Harmful if swallowed 吞咽有害
- R23 Toxic by inhalation 吸入有毒
- R34 Causes burns 会导致灼伤
- R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
- R37/38 Irritating to respiratory system and skin 对呼吸系统和皮肤有刺激性
- R41 Risk of serious damage to eyes 有严重损伤眼睛的危险
- R52/53
- R61 May cause harm to the unborn child 可能对未出生的婴儿导致伤害
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| Precautionary statements | |
|---|
- P201 Obtain special instructions before use. 使用前获取专门指示。
- P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking. 远离热源/火花/明火/热的表面。——禁止吸烟。
- P233 Keep container tightly closed. ?保持容器密闭。
- P240 Ground/bond container and receiving equipment. 与地面接触/连接集装箱和接受设备。
- P241 Use explosion-proof electrical/ventilating/lighting/…/equipment. 使用防爆电气/通风/照明/ .../设备。
- P241+P242+P243
- P242 Use only non-sparking tools. 只能使用无火花工具。
- P243 Take precautionary measures against static discharge. 采取预防措施，防止静电放电。
- P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
- P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
- P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
- P273 Avoid release to the environment. 避免释放到环境中。
- P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
- P301+P310
- P301+P312
- P301+P330+P331+P310
- P303+P361+P353
- P303+P361+P353+P310+P363
- P304+P340
- P304+P340+P310
- P305+P351+P338
- P305+P351+P338+P310
- P310 Immediately call a POISON CENTER or doctor/physician. 立即呼救解毒中心或医生/医师。
- P311 Call a POISON CENTER or doctor/physician. 呼叫解毒中心或医生/医师。
- P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适，呼叫解毒中心或医生/医师。
- P321 Specific treatment (see … on this label). 具体治疗（见本标签上的）。
- P330 Rinse mouth. 漱口
- P370+P378
- P403+P233
- P403+P235
- P405 Store locked up. 上锁保管。
- P501 Dispose of contents/container to..… 处理内容物/容器.....
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| Hazard statements | |
|---|
- H225 Highly flammable liquid and vapour 高度易燃液体和蒸气
- H226 Flammable liquid and vapour 易燃液体和蒸气
- H301 Toxic if swallowed 吞食有毒
- H302 Harmful if swallowed 吞食有害
- H314 Causes severe skin burns and eye damage 导致严重的皮肤灼伤和眼睛损伤
- H315 Causes skin irritation 会刺激皮肤
- H318 Causes serious eye damage 严重伤害眼睛
- H331 Toxic if inhaled 吸入中毒
- H335 May cause respiratory irritation 可能导致呼吸道刺激
- H360 May damage fertility or the unborn child 可能对生育能力或未出生婴儿造成伤害
- H412 Harmfutoaquaticlifewithlonglastingeffects 对水生生物有害并具有长期影响。
|
| Personal Protective Equipment |
Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
| Packing Group | II |
|---|
| UN Number |
2733
UN 2734 8/PG 2 |
| Hazard Codes |
3
F,C
T |
| Hazard Class | 3/8 |
|---|
| Storage condition |
Store in dark!
充氩保存 |
| Warnings |
危化品目录(2015) |
| Restrict |
危险品 |
常用作质子清除剂，用于肽偶联、烯醇硼化、钯(0)催化的烯丙基磷酸酯和醋酸酯的烷氧基羰基化；也可在烯基砜合成中用作催化剂。
{ALD} Merck: 14,10482
{uni_hamburg} Short: II/27B
{uni_hamburg} Short: III/38B
{ALF} Has been recommended as a base for the Horner-Wadsworth-Emmons olefination reaction, where the reagents contain groups sensitive to base-catalyzed epimerization or condensation. The reaction is carried out in the presence of LiCl, and gives high (E):(Z) ratios: Tetrahedron Lett., 25, 2183 (1984).
{ALF} Useful base in peptide coupling reactions: J. Am. Chem. Soc., 91, 6488 (1969). See Appendix 6.
{ALD} Merck: 14,10482
Beilstein: 4,IV,511
{ALF} Hindered non-nucleophilic base with high proton affinity: Chem. Ber., 91, 380 (1958).
{ALF} For use in the introduction of TBDMS protecting groups, see tert-Butyl­dimethyl­chlorosilane, A13064. Used in preparation of silyl enol ethers from both aldehydes and ketones: Helv. Chim. Acta, 60, 1801 (1977).
