Acetaldehyde 乙醛

规格: 40 wt. % in water
CAS: 75-07-0
产品编号: H93625
MDL: MFCD00006991
品牌: INFI
Chemical NameAcetaldehyde
Synonym Acetaldeyd Ethyl aldehyde acetaldehyde RCRA waste number U001 Acetic aldehyde ethanal NCI-C56326 Aldeide acetica 乙醛, 98.5% Acetylaldehyde 醋醛 乙醛 溶液 Aldehyde acetique methanecarbaldehyde Octowy aldehyd Ethanal 乙醛 乙醛溶液 Acetaldehyde Acetaldeyde Ethylaldehyd Acetaldehyd
CAS Number75-07-0
PubChem Substance ID177
EC Number200-836-8
Beilstein Registry Number505984
MDL NumberMFCD00006991
Merck Number14,39
Chemical Name Translation乙醛
Wiswesser Line NotationVH1
LabNetwork Molecule IDLN00194878
InChIInChI=1S/C2H4O/c1-2-3/h2H,1H3
GHS Symbol
TYPE OF TEST            : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - hamster
DOSE/DURATION           : 2040 ppm/7H/52W-I
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Sense Organs and Special Senses (Olfaction) - tumors
   Lungs, Thorax, or Respiration - tumors
REFERENCE :
   EJCODS European Journal of Cancer and Clinical Oncology.  (Pergamon Press,
   c/o Elsevier Science, 660 White Plains Rd., Tarrytown, NY 10591)  V.17(7)-
   25, 1981-89.  For publisher information, see EJCAEL Volume(issue)/page/year:
   18,13,1982

TYPE OF TEST            : TC - Toxic concentration (other than lowest)
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1410 ppm/6H/65W-I
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Sense Organs and Special Senses (Olfaction) - tumors
REFERENCE :
   TXCYAC Toxicology.  (Elsevier Scientific Pub. Ireland, Ltd., POB 85,
   Limerick, Ireland) V.1-    1973-  Volume(issue)/page/year: 31,123,1984

TYPE OF TEST            : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 735 ppm/6H/2Y-I
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Sense Organs and Special Senses (Olfaction) - tumors
REFERENCE :
   TXCYAC Toxicology.  (Elsevier Scientific Pub. Ireland, Ltd., POB 85,
   Limerick, Ireland) V.1-    1973-  Volume(issue)/page/year: 41,213,1986

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 300 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Lungs, Thorax, or Respiration - other changes
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 30,429,1927

TYPE OF TEST            : LD50 - Lethal dose, 50 percen

TYPE OF TEST            : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Human
DOSE/DURATION           : 134 ppm/30M
TOXIC EFFECTS :
   Lungs, Thorax, or Respiration - other changes
REFERENCE :
   JAMAAP JAMA, Journal of the American Medical Association.  (AMA, 535 N.
   Dearborn St., Chicago, IL 60610)  V.1-    1883-  Volume(issue)/page/year:
   165,1908,1957

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 640 mg/kg
TOXIC EFFECTS :
   Behavioral - general anesthetic
REFERENCE :
   APTOA6 Acta Pharmacologica et Toxicologica.  (Copenhagen, Denmark)  V.1-59,
   1945-86.  For publisher information, see PHTOEH  Volume(issue)/page/year:
   6,299,1950

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 500 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
   to Man.  (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
   V.1-    1972-  Volume(issue)/page/year: 36,101,1985

{hazard_

TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Rodent - hamster Embryo
DOSE/DURATION           : 40 ppm
REFERENCE :
   MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road,
   Eynsham, Oxford OX8 1JJ, UK) V.1- 1986-  Volume(issue)/page/year: 3,207,1988

TYPE OF TEST            : Sister chromatid exchange
TEST SYSTEM             : Human Lymphocyte
DOSE/DURATION           : 1200 umol/L
REFERENCE :
   ANYAA9 Annals of the New York Academy of Sciences.  (New York Academy of
   Sciences, 2 E. 63rd St., New York, NY 10021)  V.1-    1877-
   Volume(issue)/page/year: 543,369,1988

TYPE OF TEST            : Sex chromosome loss and nondisjunction
ROUTE OF EXPOSURE       : Parenteral
TEST SYSTEM             : Insect - Drosophila melanogaster
DOSE/DURATION           : 22500 ppm
REFERENCE :
   ENMUDM Environmental Mutagenesis.  (New York, NY)  V.1-9, 1979-87.  For
   publisher information, see EMMUEG.  Volume(issue)/page/year: 7,677,1985

TYPE OF TEST            : Sex chromosome loss and nondisjunction
TEST SYSTEM             : Mold - Aspergillus nidulans
DOSE/DURATION           : 250 ppm
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 215,187,1989

TYPE OF TEST            : DNA repair
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 7880 ug/plate
REFERENCE :
   EVHPAZ EHP, Environmental Health Perspective

TYPE OF TEST            : Mutation in mammalian somatic cells
TEST SYSTEM             : Human Fibroblast
DOSE/DURATION           : 5 mmol/L
REFERENCE :
   CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
   Southfield Road, Eynsham, Oxford OX8 1JJ, UK)  V.1-    1980-
   Volume(issue)/page/year: 15,985,1994

TYPE OF TEST            :

TYPE OF

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 600 mg/kg
SEX/DURATION            : female 8-15 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - craniofacial
   (including nose and tongue)
REFERENCE :
   SEIJBO Senten Ijo.  Congenital Anomalies.  (Nippon Senten Ijo Gakkai, c/o
   Kinki Daigaku Igakubu Kaibagaku Kyoshitsu, 380 Nishiyama, Sayama-cho,
   Mirami-Kawachi-gun, Osaka-fu, Japan) V.1-26, 1960-86. For publisher
   information, see CGANE7.  Volume(issue)/page/year: 23,13,1983

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 640 ug/kg
SEX/DURATION            : female 10 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
   TJADAB Teratology, The International Journal of Abnormal Development. (Alan
   R. Liss, Inc., 41 E. 11th St., New York, NY 10003)  V.1-    1968-
   Volume(issue)/page/year: 27,231,1983

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 5040 mg/kg
SEX/DURATION            : female 1-21 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight
   gain)
REFERENCE :
   AKYIDF Arukoru Kenkyu to Yakubutsu Izon.  Alcohol Studies and Drug
   Dependence.  (Japan Kyoto-furitsu Ika Daigaku Hoigaku Kyoshitsu, 465
   Kajii-cho, Hirokoji-agaru, Kawara-machi, Kamigyo-ku, Kyoto, 602, Japan)
   V.16-    1981-  Volume(issue)/page/year: 27,334,1992

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperiton

WGK Germany1
Hazard Codes 3 F+,Xn F,Xn
Hazard statements
  • H351 Suspected of causing cancer 怀疑致癌
  • H224 Extremely flammable liquid and vapour 极端易燃液体和蒸气
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
  • H317 May cause an allergic skin reaction 可能导致皮肤过敏
  • H302 Harmful if swallowed 吞食有害
  • H318 Causes serious eye damage 严重伤害眼睛
  • H336 May cause drowsiness or dizziness 肯能导致嗜睡或头晕
  • H225 Highly flammable liquid and vapour 高度易燃液体和蒸气
    Personal Protective Equipment Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US)
    RTECSAB1925000
    Precautionary statements
    • P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking. 远离热源/火花/明火/热的表面。——禁止吸烟。
    • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
    • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
    • P281 Use personal protective equipment as required. 使用所需的个人防护装备。
    • P304+P340+P312
    • P305+P351+P338
    • P337+P313
    • P370+P378
    • P403+P235
      Signal word Danger
      Safety Statements
      • S16 Keep away from sources of ignition - No smoking 远离火源,禁止吸烟;
      • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后,立即用大量水冲洗并征求医生意见;
      • S29 Do not empty into drains 不要排入下水道;
      • S33 Take precautionary measures against static discharges 对静电采取预防措施;
      • S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套;
      • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护;
        Risk Statements
        • R11 Highly flammable 非常易燃
        • R12 Extremely flammable 极端易燃
        • R19 May form explosive peroxides 可能生成易爆的过氧化物质
        • R36/37 Irritating to eyes and respiratory system 对眼睛和呼吸系统有刺激性
        • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
        • R36/38 Irritating to eyes and skin 对眼睛和皮肤有刺激性
        • R40 Limited evidence of a carcinogenic effect 有限证据表明其致癌作用
        • R67 Vapours may cause drowsiness and dizziness 蒸汽可能导致嗜睡和昏厥
          UN Number 1089 1993
          Packing GroupII
          Storage condition 储存温度 2-8°C,充氮保存 储存温度2-8℃;充氩储存 储存温度2-8℃
          Warnings 危化品目录(2015)
          Restrict 危险品
        • ⑴. 化学性质活泼,分子中的羰基易进行加成、环化和聚合反应。易氧化成乙酸。在水中可形成水合物。遇明火、高热极易燃烧爆炸。
        • ⑵. 乙醛为易燃有毒液体。对眼、皮肤和呼吸器官有刺激作用。轻度中毒会引起气喘、咳嗽及头痛等症状,重者会引起肺炎及脑膜炎。长期接触会引起红细胞降低、血压升高。小鼠灌胃LD50:1232mg/kg。操作现场空气中最高容许浓度200*10-6。操作人员必须穿戴好劳动保护用具。
        • ⑶. 蒸气与空气形成爆炸性混合物,爆炸极限4.1%~57.0%(体积)。
        • ⑷. 比色法测定醛时用以制备标准溶液、还原
        • {SA} Baraona, E., and Lieber, C.S., Alcohol and lipids. Recent Dev. Alcohol. 14 , 97-134, (1998)
        • {ALD} Merck: 14,39
        • Beilstein: 1,IV,3094
        • {uni_hamburg} Short: II/14a
        • {uni_hamburg} Short: II/19b
        • {ALD} Merck: 14,39
        • 75-07-0 H93625 Acetaldehyde
乙醛

          化学属性

          Mol. FormulaC2H4O
          Mol. Weight44
          Refractive indexn20/D 1.389
          Boiling Point21 °C(lit.)
          Density0.95-0.98
          Melting Point-125 °C(lit.)
          Flash Point-27°(-17°F)
          TSCAYes
          Autoignition Point365 °F
          Vapor Density1.52 (vs air)
          Vapor Pressure14.63 psi ( 20 °C)
          Solubility> 500 G/L (20 ºC)
          Stability对热和光线敏感
          pH:A

          *以上化合物性质及应用等信息仅供参考