3-Chloro-2-methylpropen 3-chloro-2-methylprop-1-ene

规格:
CAS: 563-47-3
产品编号: HXYJ0000001322
MDL: MFCD00000953
品牌: Bellen
Chemical Name3-Chloro-2-methylpropene
Synonym {uni_hamburg} {Chem NCI-C54820 Methylallyl chloride isobutenyl chloride 2-Methyl-2-propenyl chloride 1-Chloro-2-methyl-2-propene 氯化异丁烯 3-chloro-2-methylpropene 2-Methallyl chloride methallyl chloride 3-氯-2-甲基-1-丙烯(MAC) {hazard_co {Chemi γ-Chloroisobutylene {uni_hambu methylallyl chloride 2-甲基烯丙基氯 3-CHLORO-2-METHYLPROPENE 3-Chlorisobutylen 2-Methylallyl chloride 3-Chloroisobutylene 甲代烯丙基氯 3-chloro-2-methylprop-2-en 异丁烯基氯 2-(Chloromethyl)-1-propene 1-氯-2-甲基-2-丙烯 3-chloro-2-methyl-propene 2-Methyl-3-chloro-1-propene β-Methallyl c Γ-氯异丁烯
CAS Number563-47-3
EC Number209-251-2
Beilstein Registry Number1,209
MDL NumberMFCD00000953
PubChem Substance ID87565372
Merck Number2148
Reaxys-RN878160
Chemical Name Translation3-氯-2-甲基丙烯
Wiswesser Line NotationG1Y1&U1
LabNetwork Molecule IDLN00224131
InChIInChI=1S/C4H7Cl/c1-4(2)3-5/h1,3H2,2H3
GHS Symbol
TYPE OF TEST            : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 77250 mg/kg/2Y-I
TOXIC EFFECTS :
   Tumorigenic - neoplastic by RTECS criteria
   Gastrointestinal - tumors
   Reproductive - Tumorigenic effects - testicular tumors
REFERENCE :
   NTPTR* National Toxicology Program Technical Report Series.  (Research
   Triangle Park, NC 27709) No.206-  Volume(issue)/page/year: NTP-TR-300,1986

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 51500 mg/kg/2Y-I
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Gastrointestinal - tumors
REFERENCE :
   NTPTR* National Toxicology Program Technical Report Series.  (Research
   Triangle Park, NC 27709) No.206-  Volume(issue)/page/year: NTP-TR-300,1986

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 38625 mg/kg/2Y-I
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Gastrointestinal - tumors
REFERENCE :
   PAACA3 Proceedings of the American Association for Cancer Research. (Waverly
   Press, 428 E. Preston St., Baltimore, MD 21202)  V.1-    1954-
   Volume(issue)/page/year: 26,95,1985

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 51500 mg/kg/2Y-I
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Gastrointestinal - tumors
REFERENCE :
   PAACA3 Proceedings of the American Association for Cancer Research. (Waverly
   Press, 428 E. Preston St., Baltimore, MD 21202)  V.1-    1954-
   Volume(issue)/page/year: 26,95,1985

TYPE OF TES

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 3160 mg/kg
TOXIC EFFECTS :
   Gastrointestinal - other changes
   Liver - other changes
   Blood - changes in spleen
REFERENCE :
   NTPTR* National Toxicology Program Technical Report Series.  (Research
   Triangle Park, NC 27709) No.206-  Volume(issue)/page/year: NTP-TR-300,1986

TYPE OF TEST            : LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 34 gm/m3/30M
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   FAVUAI Fiziologicheski Aktivnye Veshchestva.  Physiologically Active
   Substances.  (Izdatel'stvo Naukova Dumka, Kiev, USSR)  No.1-    1966-
   Volume(issue)/page/year: 7,35,1975

TYPE OF TEST            : LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Human
DOSE/DURATION           : 22000 ppm/10M
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   34ZIAG "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York,
   Academic Press, Inc., 1969  Volume(issue)/page/year: -,377,1969

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 848 mg/kg
TOXIC EFFECTS :
   Behavioral - tremor
   Gastrointestinal - hypermotility, diarrhea
   Blood - hemorrhage
REFERENCE :
   NTIS** National Technical Information Service.  (Springfield, VA 22161)
   Formerly U.S. Clearinghouse for Scientific & Technical Information.
   Volume(issue)/page/year: OTS0539687

TYPE OF TEST            : Mutation in mammalian somatic cells
TEST SYSTEM             : Rodent - mouse Lymphocyte
DOSE/DURATION           : 23200 ug/L
REFERENCE :
   SCIEAS Science.  (American Assoc. for the Advancement of Science, 1333 H
   St., NW, Washington, DC 20005)  V.1-    1895-  Volume(issue)/page/year:
   236,933,1987

TYPE OF TEST            : Sex chromosome loss and nondisjunction
ROUTE OF EXPOSURE       : Oral
TEST SYSTEM             : Insect - Drosophila melanogaster
DOSE/DURATION           : 4500 ppm
REFERENCE :
   EMMUEG Environmental and Molecular Mutagenesis.  (Alan R. Liss, Inc., 41 E.
   11th St., New York, NY 10003)  V.10-    1987-  Volume(issue)/page/year:
   23,208,1994

TYPE OF TEST            : Unscheduled DNA synthesis
TEST SYSTEM             : Human HeLa cell
DOSE/DURATION           : 1 mmol/L
REFERENCE :
   CALEDQ Cancer Letters (Shannon, Ireland).  (Elsevier Scientific Pub. Ireland
   Ltd., POB 85, Limerick, Ireland)  V.1-    1975- Volume(issue)/page/year:
   20,263,1983

TYPE OF TEST            : Sister chromatid exchange
TEST SYSTEM             : Rodent - hamster Ovary
DOSE/DURATION           : 16 mg/L
REFERENCE :
   EMMUEG Environmental and Molecular Mutagenesis.  (Alan R. Liss, Inc., 41 E.
   11th St., New York, NY 10003)  V.10-    1987-  Volume(issue)/page/year:
   13,133,1989

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 6 umol/plate
REFERENCE :
   BCPCA6 Biochemical Pharmacology.  (Pergamon Press Inc., Maxwell House,
   Fairview Park, Elmsford, NY 10523)  V.1-    1958-  Volume(issue)/page/year:
   29,2611,1980

TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Rodent - hamster Ovary
DOSE/DURATION           : 200 mg/L
REFERENCE :
   NTPTR* National Toxicology Program Technical Report Series.  (Research

Signal word
WGK Germany2
Safety Statements
  • S9 Keep container in a well-ventilated place 保持容器在通风良好的场所;
  • S16 Keep away from sources of ignition - No smoking 远离火源,禁止吸烟;
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时,立即求医(可能时出示标签);
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后,立即用大量水冲洗并征求医生意见;
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护;
  • S29 Do not empty into drains 不要排入下水道;
  • S61 Avoid release to the environment. Refer to special instructions/safety data sheet 避免释放到环境中,参考特别指示/安全收据说明书;
    Risk Statements
    • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
    • R34 Causes burns 会导致灼伤
    • R51/53
    • R20/22 Harmful by inhalation and if swallowed 吸入和不慎吞咽有害
    • R43 May cause sensitisation by skin contact 皮肤接触会产生过敏反应
    • R11 Highly flammable 非常易燃
      Precautionary statements
      • P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking. 远离热源/火花/明火/热的表面。——禁止吸烟。
      • P233 Keep container tightly closed. ?保持容器密闭。
      • P240 Ground/bond container and receiving equipment. 与地面接触/连接集装箱和接受设备。
      • P241+P242+P243
      • P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
      • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
      • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
      • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西,喝水或吸烟。
      • P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
      • P272 Contaminated work clothing should not be allowed out of the workplace. 污染的工作服不得带出工作场所。
      • P273 Avoid release to the environment. 避免释放到环境中。
      • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
      • P301+P330+P331+P310
      • P303+P361+P353
      • P303+P361+P353+P310+P363
      • P304+P340+P310
      • P305+P351+P338
      • P305+P351+P338+P310
      • P308+P311
      • P310 Immediately call a POISON CENTER or doctor/physician. 立即呼救解毒中心或医生/医师。
      • P370+P378
      • P391 Collect spillage. Hazardous to the aquatic environment 收集对水环境有危害的泄漏物。
      • P403+P233
      • P405 Store locked up. 上锁保管。
      • P501 Dispose of contents/container to..… 处理内容物/容器.....
        Hazard statements
        • H225 Highly flammable liquid and vapour 高度易燃液体和蒸气
        • H302 Harmful if swallowed 吞食有害
        • H302+H332
        • H314 Causes severe skin burns and eye damage 导致严重的皮肤灼伤和眼睛损伤
        • H317 May cause an allergic skin reaction 可能导致皮肤过敏
        • H332 Harmful if inhaled 吸入有害
        • H411 Toxictoaquaticlifewithlonglastingeffects 对水生生物有毒性并具有长期影响。
          Personal Protective Equipment Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
          RTECSUC8050000
          Packing GroupII
          UN Number 2554
          Hazard Codes 3
          Hazard Class3
          Storage condition Refrigerator (+4°C) + Flammables area
          Warnings 危化品目录(2015)
          Restrict 危险品
        • 用作杀虫剂、塑料、药品等的中间体。
        • {uni_hamburg} Short: II/25C
        • {uni_hamburg} Short: III/20a
        • {ALD} Merck:14,2148
        • {ALD} Merck:14,2148
        • Beilstein:1,209
        • 563-47-3 HXYJ0000001322 3-Chloro-2-methylpropen	3-chloro-2-methylprop-1-ene

          化学属性

          Mol. FormulaC4H7Cl
          Mol. Weight91
          Density0.925
          Refractive index1.4260 to 1.4280
          Autoignition Point899 °F
          Vapor Density3.12 (vs air)
          Boiling Point73°C
          Vapor Pressure102 mmHg ( 20 °C)
          Melting Point-80
          Flash Point-12°C
          TSCAYes
          Solubility微溶于水。

          *以上化合物性质及应用等信息仅供参考