2-Butyne-1,4-diol 丁炔二醇

规格:
CAS: 110-65-6
产品编号: HXYJ0000002668
MDL: MFCD00002915
品牌: Bellen
Chemical Name2-Butyne-1,4-diol
CAS Number110-65-6
PubChem Substance ID87563749
EC Number203-788-6
Beilstein Registry Number1071237
MDL NumberMFCD00002915
Reaxys-RN1071237
Synonym 1,4-Dihydroxy-2-butyne, 1,2-Dihydroxydimethylacetylene 2-Butin-1,4-diol 2-丁炔-1,4-二醇 Bis(hydroxymethyl)acetylene but-2-yne-1,4-diol
Chemical Name Translation丁炔二醇
Wiswesser Line NotationQ2UU2Q
LabNetwork Molecule IDLN00193774
InChIInChI=1S/C4H6O2/c5-3-1-2-4-6/h5-6H,3-4H2
GHS Symbol
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 150 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Lungs, Thorax, or Respiration - respiratory stimulation
   Blood - other changes
REFERENCE :
   HYSAAV Hygiene and Sanitation (USSR).  English translation of GISAAA.
   (Springfield, VA)  1964-

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 105 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Lungs, Thorax, or Respiration - respiratory stimulation
   Blood - other changes
REFERENCE :
   HYSAAV Hygiene and Sanitation (USSR).  English translation of GISAAA.
   (Springfield, VA)  1964-71. Discontinued.  Volume(issue)/page/year:
   33(1-3),41,1968

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 105 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Lungs, Thorax, or Respiration - respiratory stimulation
   Blood - other changes
REFERENCE :
   HYSAAV Hygiene and Sanitation (USSR).  English translation of GISAAA.
   (Springfield, VA)  1964-71. Discontinued.  Volume(issue)/page/year:
   33(1-3),41,1968

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 52435 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JPPMAB Journal of Pharmacy and Pharmacology.  (Pharmaceutical Soc. of Great
   Britain, 1 Lambeth High St., London SEI 7JN, UK)  V.1-    1949-
   Volume(issue)/page/year: 26,597,1974

WGK Germany2
Hazard statements
  • H314 Causes severe skin burns and eye damage 导致严重的皮肤灼伤和眼睛损伤
  • H317 May cause an allergic skin reaction 可能导致皮肤过敏
  • H301+H331
  • H373 May causes damage to organs through prolonged or repeated exposure 长期或频繁接触可能会损伤器官
  • H312 Harmful in contact with skin 皮肤接触有害
  • H301+H311+H331
  • H331 Toxic if inhaled 吸入中毒
  • H301 Toxic if swallowed 吞食有毒
    Personal Protective Equipment Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
    Hazard Codes 6.1 T
    RTECSES0525000
    Precautionary statements
    • P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
    • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
    • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
    • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
    • P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
    • P273 Avoid release to the environment. 避免释放到环境中。
    • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
    • P301+P310
    • P301+P330+P331+P310
    • P303+P361+P353
    • P303+P361+P353+P310+P363
    • P304+P340+P310
    • P304+P340+P311
    • P305+P351+P338
    • P305+P351+P338+P310
    • P308+P311
    • P310 Immediately call a POISON CENTER or doctor/physician. 立即呼救解毒中心或医生/医师。
    • P403+P233
    • P501 Dispose of contents/container to..… 处理内容物/容器.....
      Signal word Danger
      UN Number 2716
      Storage condition 0-10 密闭贮存. 0-10°C 储存温度2-8℃,充氩保存
      Safety Statements
      • S25 Avoid contact with eyes 避免眼睛接触；
      • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
      • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
      • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
      • S46 If swallowed, seek medical advice immediately and show this container or label 食入时，立即求医并出示容器/标签；
        Risk Statements
        • R21 Harmful in contact with skin 与皮肤接触有害
        • R23/25 Toxic by inhalation and if swallowed 吸入及吞食都有毒
        • R34 Causes burns 会导致灼伤
        • R43 May cause sensitisation by skin contact 皮肤接触会产生过敏反应
        • R48/22
          Packing GroupIII
          Hazard Class6.1
          Warnings 危化品目录(2015)
          Restrict 危险品
        • 丁二烯合成的中间体，腐蚀抑制剂，电镀光亮剂，聚合催化剂，脱叶剂，氯烃稳定剂。
        • {ALD} Beilstein:1(1)261
        • {uni_hamburg} Short: II/27B
        • {ALF} Undergoes an interesting trans-addition reaction with Grignard reagents: Chem. Lett., 765 (1984):
        • {uni_hamburg} Short: III/38B
          • 110-65-6 HXYJ0000002668 2-Butyne-1,4-diol 丁炔二醇

          化学属性

          Mol. FormulaC4H6O2
          Mol. Weight86
          Boiling Point238
          Melting Point54-58
          Flash Point152°(305°F)
          TSCAYes
          Vapor Pressure<;0.1 mmHg ( 55 °C)
          Refractive index1.480
          Density1.2
          Solubility易溶于水，易溶于甲醇、乙醇，不溶于乙醚、苯、氯仿。
          Stability对湿度敏感

          *以上化合物性质及应用等信息仅供参考