(FORMYLMETHYLENE)TRIPHENYLPHOSPHORANE 三苯基磷

规格:
CAS: 603-35-0
产品编号: HXYJ0000003404
MDL: MFCD00003043
品牌: Bellen
Chemical NameTriphenylphosphine
EC Number210-036-0
Beilstein Registry Number610776
Synonym Triphenylphosphine {LY} Triphenylphosphine phosphine,triphenyl triphenyl-phosphane triphenyl-phosphin triphenylphosphine triphenylphosphine hydrobromide triphenylphosphine hydrochloride {} {LY} Triphenylphosphine {} {} {LY} Triphenylphosphine {} {} {} {LY} Triphenylphosphine {} {} {} {} {LY} Triphenylphosphine {} {} {} {} {} {LY} Triphenylphosphine {} {} {} {} {} {} {LY} Triphenylphosphine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Triphenylphosphine {} {} {} {} {} {} {} {} {LY} Triphenylphosphine {} {} {} {} {} {} {} {} {} {LY} Triphenylphosphine {} {} {} {} {} {} {} {} {} {} {LY} Triphenylphosphine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Triphenylphosphine {} {} {} {} {} {} {} {} {} {} {} {} {LY} Triphenylphosphine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Triphenylphosphine {} {} {} {} {} {} {} {} {} {}
Merck Number9743
PubChem Substance ID11776
Chemical Name Translation三苯基膦
Reaxys-RN610776
Wiswesser Line NotationRPR&R
LabNetwork Molecule IDLN00198869
InChIInChI=1S/C18H15P/c1-4-10-16(11-5-1)19(17-12-6-2-7-13-17)18-14-8-3-9-15-18/h1-15H
MDL NumberMFCD00003043
CAS Number603-35-0
Canonical SMILESP(C1=CC=CC=C1)(C2=CC=CC=C2)C3=CC=CC=C3
GHS Symbol
TYPE OF TEST            : LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1135 ppm/4H
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - lacrimation
   Lungs, Thorax, or Respiration - dyspnea
   Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
   AIHAM* Annual Meeting of American Industrial Hygiene Association.  (Akron,
   OH)  For publisher information, see AIHAAP.  Volume(issue)/page/year:
   -,-,1969

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 3 gm/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
REFERENCE :
   EPASR* United States Environmental Protection Agency, Office of Pesticides
   and Toxic Substances. (U.S. Environmental Protection Agency, 401 M St., SW,
   Washington, DC 20460)  History unknown.  Volume(issue)/page/year:
   8EHQ-0384-0014

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : >500 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Lungs, Thorax, or Respiration - dyspnea
   Gastrointestinal - changes in structure or function of salivary glands
REFERENCE :
   NTIS** National Technical Information Service.  (Springfield, VA 22161)
   Formerly U.S. Clearinghouse for Scientific & Tech

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 700 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
REFERENCE :
   EPASR* United States Environmental Protection Agency, Office of Pesticides
   and Toxic Subs

Signal word Warning
WGK Germany2
Safety Statements
  • S22 Do not breathe dust 不要吸入粉尘；
  • S24 Avoid contact with skin 避免皮肤接触；
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
  • S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
  • S37 Wear suitable gloves 戴适当手套；
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
  • S60 This material and its container must be disposed of as hazardous waste 该物质及其容器必须作为危险废物处置；
  • S61 Avoid release to the environment. Refer to special instructions/safety data sheet 避免释放到环境中，参考特别指示/安全收据说明书；
    Risk Statements
    • R22 Harmful if swallowed 吞咽有害
    • R43 May cause sensitisation by skin contact 皮肤接触会产生过敏反应
    • R48/20/22
    • R53 May cause long-term adverse effects in the aquatic environment 对水生环境有长期的有害作用
      Precautionary statements
      • P201 Obtain special instructions before use. 使用前获取专门指示。
      • P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前，切勿操作。
      • P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
      • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
      • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
      • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
      • P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
      • P272 Contaminated work clothing should not be allowed out of the workplace. 污染的工作服不得带出工作场所。
      • P273 Avoid release to the environment. 避免释放到环境中。
      • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
      • P281 Use personal protective equipment as required. 使用所需的个人防护装备。
      • P301+P312
      • P301+P312+P330
      • P302+P350
      • P302+P352
      • P302+P352+P333+P313+P362+P364
      • P304+P312
      • P304+P340
      • P304+P340+P312
      • P305+P351+P338
      • P305+P351+P338+P337+P313
      • P308+P313
      • P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适，呼叫解毒中心或医生/医师。
      • P314 Get medical advice/attention if you feel unwell. 获取医疗咨询/就医，如果你觉得不舒服
      • P321 Specific treatment (see … on this label). 具体治疗（见本标签上的）。
      • P322 Specific measures (see …on this label). 具体治疗（见本标签上的）。
      • P330 Rinse mouth. 漱口
      • P332+P313
      • P333+P313
      • P337+P313
      • P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服，清洗后方可重新使用
      • P363 Wash contaminated clothing before reuse. 被污染的衣服洗净后方可重新使用。
      • P403+P233
      • P405 Store locked up. 上锁保管。
      • P501 Dispose of contents/container to..… 处理内容物/容器.....
        Hazard statements
        • H302 Harmful if swallowed 吞食有害
        • H302+H332
        • H312 Harmful in contact with skin 皮肤接触有害
        • H315 Causes skin irritation 会刺激皮肤
        • H317 May cause an allergic skin reaction 可能导致皮肤过敏
        • H319 Causes serious eye irritation 严重刺激眼睛
        • H332 Harmful if inhaled 吸入有害
        • H335 May cause respiratory irritation 可能导致呼吸道刺激
        • H350 May cause cancer 可能致癌
        • H373 May causes damage to organs through prolonged or repeated exposure 长期或频繁接触可能会损伤器官
        • H412 Harmfutoaquaticlifewithlonglastingeffects 对水生生物有害并具有长期影响。
        • H413 Maycauselonglastingharmfuleffectstoaquaticlife 可能对水生生物造成长期持续有害影响。
          Personal Protective Equipment dust mask type N95 (US), Eyeshields, Faceshields, Gloves
          RTECSSZ3500000
          Hazard Codes Xn
          Storage condition Store at room temperature {LY} Store at room temperature {} {LY} Store at room temperature {} {} {LY} Store at room temperature {} {} {} {LY} Store at room temperature {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {}
          UN Number
          Warnings 危化品目录(2015)
          Packing GroupIII
          Restrict -
        • 用于有机合成，聚合引发剂，抗菌素类药物氯洁霉素的原料，有机微量分析测定磷的标准样品。
        • {ALF} Azides can be converted selectively to amines, in the presence of ester, epoxide or nitro groups, by reduction to iminophosphoranes (Staudinger reaction), followed by hydrolysis. For reviews, see: Tetrahedron, 37, 437 (1981); 48, 1353 (1992):
        • {ALF} Finds widespread use as a complexing agent with transition metals, either in the preparation of stable complexes, or as an additive in metal-promoted reactions. See also Tri(o-tolyl)­phosphine, A12093 and Tri(2-furyl)­phosphine, L13329.
        • {ALF} For use in peptide and other coupling reactions, see 2,2'-Dipyridyl­ disulfide, A11118.
        • {ALF} In suitable circumstances, the iminophosphorane may undergo intramolecular aza-Wittig reaction: Tetrahedron, 45, 6375 (1989):
        • {ALF} Reviews: Aza-Wittig reaction in heterocyclic synthesis: Org. Prep. Proced. Int., 24, 209 (1992); Iminophosphoranes as building blocks for the preparation of N-containing heterocycles: Synthesis, 1197 (1994).
        • {ALD} Merck: 14,9743
        • Beilstein:16,759
        • {ALD} Merck: 14,9743
        • {ALF} For use in the Mitsunobu reaction for conversion of alcohols to alkylating agents, see N-Guanyl­urea sulfate, A19106, and Diisopropyl­ azodicarboxyl­ate, L10386. See also 1,2-Bis(diphenyl­phosphino)­ethane, A11419.
          • 603-35-0 HXYJ0000003404 (FORMYLMETHYLENE)TRIPHENYLPHOSPHORANE 三苯基磷

          化学属性

          Density1.132
          Vapor Density9 (vs air)
          Vapor Pressure5 mmHg ( 20 °C)
          TSCAYes
          SolubilitySoluble in ether, acetone, chloroform (50 mg/ml), and alcohol. Insoluble in water.
          Stability对光敏感
          Mol. FormulaC18H15P
          Mol. Weight262.29
          Flash Point359°F
          Appearance white xtl.
          Boiling Point377
          Melting Point79-81
          Danger-Level乙类
          pH-:-
          Redox-

          *以上化合物性质及应用等信息仅供参考