Chemical Name | 1,4,8,11-Tetraazacyclotetradecane |
CAS Number | 295-37-4 |
Synonym |
1,1',1''-(1,4,8,11-Tetraazacyclotetradecane-1,4,8-triyl)tris[2,2,2-trifluoro-ethanone
1,4,8,11-TETRAAZACYCLOTETRADECANE(CYCLAM)
1,4,8,11-TETRAAZACYCLOTETRADECANE, 98+%
1,4,8,11-Tetraazacyclotetradecane 98%
1,4,8,11-四叠氮环十四烷
1,4,8,11-四氮杂环十四烷
1,4,8,11-四氮环十四烷
1,4,8,11-四氮环十四烷, 98+%
1,4,8-Tris(trifluoroacetyl)-1,4,8,11-tetraazacyclo
1,4,8-Tris(trifluoroacetyl)-1,4,8,11-tetraazacyclotetradecane
CYCLAM
Cyclam
Cyclam, 98+%
Cyclam=1,4,8,11-Tetraazacyclotetradecane
JM 1498
jm1498 |
EC Number | 206-039-1 |
Beilstein Registry Number | 111811 |
MDL Number | MFCD00005105 |
PubChem Substance ID | 64964 |
Alfabeta Name | TETRAAZACYCLOTETRADECANE 14811-,,, |
Reaxys-RN | 111811 |
Chemical Name Translation | 1,4,8,11-四氮杂环十四烷 |
InChIKey | MDAXKAUIABOHTD-UHFFFAOYSA-N |
LabNetwork Molecule ID | LN00184756 |
InChI | InChI=1S/C10H24N4/c1-3-11-7-9-13-5-2-6-14-10-8-12-4-1/h11-14H,1-10H2 |
Signal word |
Warning |
GHS Symbol
WGK Germany | 3 |
Safety Statements | |
- S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后,立即用大量水冲洗并征求医生意见;
- S36 Wear suitable protective clothing 穿戴适当的防护服;
- S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护;
- S37 Wear suitable gloves 戴适当手套;
|
Risk Statements | |
- R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
|
Precautionary statements | |
- P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
- P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
- P302+P352+P332+P313+P362+P364
- P305+P351+P338
- P305+P351+P338+P337+P313
- P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服,清洗后方可重新使用
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Hazard statements | |
- H315 Causes skin irritation 会刺激皮肤
- H319 Causes serious eye irritation 严重刺激眼睛
- H335 May cause respiratory irritation 可能导致呼吸道刺激
|
RTECS | XA5254800 |
Personal Protective Equipment |
dust mask type N95 (US), Eyeshields, Gloves |
Storage condition |
Air Sensitive |
Hazard Codes |
Xi |
Warnings |
IRRITANT |
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 371 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
Skin and Appendages - primary irritation (after topical exposure)
REFERENCE :
CMSHAF Chemosphere. (Pergamon Press Inc., Maxwell House, Fairview Park,
Elmsford, NY 10523) V.1- 1972- Volume(issue)/page/year: 17,839,1988
Reagent used in the preparation of Plerixafor derivatives.
{ALF} The Ni(II) complex catalyzes the novel electrochemical reaction of epoxides with carbon dioxide to give good yields of cyclic carbonates: J. Chem. Soc., Chem. Commun., 43 (1995). A similar system catalyzes the electrochemical intramolecular reductive cyclization of a series of o-halogenated aryl alkenes: Tetrahedron Lett., 36, 4429 (1995):
{ALF} For use in synthesis of molecules with electroactive cavities, see (Ferrocenyl­methyl)­trimethyl­ammonium iodide, 39399.
{ALF}
{ALF} Nitrogen analogue of the crown ethers (see Appendix 2), forming stable complexes with metal ions: Inorg. Chem., 4,1102, 1109 (1965); Can. J. Chem., 48, 1481 (1970). For examples
{uni_hamburg} Short: III/35B
{uni_hamburg} Short: IV/20C
{ALF} Complex with iron(II) triflate is an effective epoxidation catalyst: J. Am. Chem. Soc., 113, 7052 (1991).
{uni_hamburg} Short: EINECS
{ALF} Nitrogen analogue of the crown ethers (see Appendix 2), forming stable complexes with metal ions: Inorg. Chem., 4,1102, 1109 (1965); Can. J. Chem., 48, 1481 (1970). For examples of use as a versatile ligand in coordination chemistry, see: Acc. Chem. Res., 11, 392 (1978); J. Chem. Soc., Chem. Commun., 1322 (1986); 1075 (1987); 156 (1988); Inorg. Chem., 26, 908 (1987); J. Am. Chem. Soc., 110, 3679 (1988).
{TRC} Jacobson, O., et al.: Bioorg. Med. Chem., 17, 1486 (2009),