Chemical Name | Methyllithium |
Synonym |
Methyl lithium,1.6M in Diethoxymethane,Safeseal
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{} {} {} {} {} {} {} {} {} {} {} {} {LY} Methyl lithium,1.6M in Diethoxymethane,Safes |
CAS Number | 917-54-4 |
EC Number | 213-026-4 |
Beilstein Registry Number | 3587162 |
MDL Number | MFCD00008253 |
PubChem Substance ID | 2724049 |
Reaxys-RN | 3587162 |
Chemical Name Translation | 甲基锂 |
InChIKey | DVSDBMFJEQPWNO-UHFFFAOYSA-N |
LabNetwork Molecule ID | LN00164399 |
InChI | InChI=1S/CH3.Li/h1H3;/q-1;+1 |
Canonical SMILES | C[Li] |
Signal word |
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GHS Symbol
WGK Germany | 2 |
Safety Statements | |
- S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时,立即求医(可能时出示标签);
- S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后,立即用大量水冲洗并征求医生意见;
- S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护;
- S43 In case of fire use ... (indicate in the space the precise type of fire-fighting equipment. If water increases the risk add -?Never use water) 着火时使用(指明具体的消防器材种类,如果用水增加危险,注明“禁止用水”
- S16 Keep away from sources of ignition - No smoking 远离火源,禁止吸烟;
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Risk Statements | |
- R12 Extremely flammable 极端易燃
- R15 Contact with water liberates extremely flammable gases 遇水会释放出极端易燃的气体
- R17 Spontaneously flammable in air 在空气中能够自燃
- R22 Harmful if swallowed 吞咽有害
- R34 Causes burns 会导致灼伤
- R66 Repeated exposure may cause skin dryness or cracking 反复接触可能导致皮肤干燥或皴裂
- R67 Vapours may cause drowsiness and dizziness 蒸汽可能导致嗜睡和昏厥
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Precautionary statements | |
- P222 Do not allow contact with air. 不要与空气接触。
- P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
- P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
- P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P305+P351+P338
- P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
- P240 Ground/bond container and receiving equipment. 与地面接触/连接集装箱和接受设备。
- P370+P378
- P223 Keep away from any possible contact with water, because of violent reaction and possible flash fire. 远离任何与水接触的可能,因为会剧烈反应可能产生闪火。
- P422 Store contents under… 存储目录在…之下。
- P231+P232
- P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking. 远离热源/火花/明火/热的表面。——禁止吸烟。
- P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P308+P313
- P403+P233
- P305+P351+P338+P310
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Hazard statements | |
- H314 Causes severe skin burns and eye damage 导致严重的皮肤灼伤和眼睛损伤
- H304 May be fatal if swallowed and enters airways 吞食和进入呼吸道可能致命
- H335 May cause respiratory irritation 可能导致呼吸道刺激
- H411 Toxictoaquaticlifewithlonglastingeffects 对水生生物有毒性并具有长期影响。
- H260 In contact with water releases flammable gases which may ignite spontaneously 与水接触时释放可燃气体,可自燃。
- H225 Highly flammable liquid and vapour 高度易燃液体和蒸气
- H250 Catches fire spontaneously if exposed to air 暴露于空气自发着火
- H224 Extremely flammable liquid and vapour 极端易燃液体和蒸气
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Personal Protective Equipment |
Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
Packing Group | I |
UN Number |
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Storage condition |
Store at room temperature, keep dry and cool
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Hazard Codes |
4.2 |
Hazard Class | 4.2/4.3 |
Warnings |
危化品目录(2015) |
Restrict |
危险品 |
⑴.本品较为稳定。
⑵. 碱性试剂和还原剂。用于丙二烯合成。a一轻酮转变成顺式二醇,从梭酸制酮。分解醋酸醋。使烯醇乙酸醋成烯醇负离子制a一溴代酮或a,一不饱和酮。合成螺戊烷。从丫一酮酸醋制日一二酮。与日、丫一不饱和酸反应成醋a芳香醛酮的甲基化一还.原。烯基砜的锉化。
⑶. 可以对多种官能团进行甲基化,可以脱除保护基团,合成其它甲基化有机金属试剂,可以作为碱以及还原过渡金属等。溶剂和卤素对用到非溶剂化的甲基锂的反应有很大的影响。
①.加成反应 ;与甲基格氏试剂相比,甲基锂与环烃、杂环以及脂肪族化合物的1,2
有机催化剂反应。
{uni_hamburg} Short: III/35C4
{uni_hamburg} Short: III/20a
{uni_hamburg} Short: II/2
{ALD} Beilstein:4(4)4417