Chemical Name | Bis(trimethylsilyl)amine |
Synonym |
(dimethyl-trimethylsilylamino-silyl)methane
1,1,1,3,3,3-Hexamithyl disilazane
1,1,1-trimethyl-n-(trimethylsilyl)-silanamin
1,1,1-三甲基-N-(三甲基甲硅烷基)硅烷胺
BSTFA
Bis(trimethylsilyl)amine
Bis-(trimethylsilyl)-amin
Dow Corning® 产品 Z-6079 HMDS
HEXAMETHYLDISILYLAMINE
N-lithiohexamethyldisilazane
Silanamine, 1,1,1-trimethyl-N-(trimethylsilyl)-
hexamethyldisilazane
hexamethylsil
hexamethylsilazane
hexamethylsilazane, aluminum salt
hexamethylsilazane, beryllium salt
hexamethylsilazane, cadmium salt
hexamethylsilazane, cerium (+3) salt
hexamethylsilazane, chromium (3+) salt
hexamethylsilazane, cobalt (2+) salt
hexamethylsilazane, europium (3+) salt
hexamethylsilazane, gadolinium (3+) salt
hexamethylsilazane, gallium salt |
CAS Number | 999-97-3 |
PubChem Substance ID | 13838 |
EC Number | 213-668-5 |
Beilstein Registry Number | 635752 |
MDL Number | MFCD00008259 |
Reaxys-RN | 635752 |
Merck Number | 4689 |
Chemical Name Translation | 六甲基二硅氮烷 |
Wiswesser Line Notation | 1-SI-1&1&M-SI-1&1&1 |
LabNetwork Molecule ID | LN00195588 |
InChI | InChI=1S/C6H19NSi2/c1-8(2,3)7-9(4,5)6/h7H,1-6H3 |
GHS Symbol
WGK Germany | 2 |
Hazard statements | |
- H225 Highly flammable liquid and vapour 高度易燃液体和蒸气
- H302 Harmful if swallowed 吞食有害
- H302+H332
- H311 Toxic in contact with skin 皮肤接触中毒
- H312 Harmful in contact with skin 皮肤接触有害
- H314 Causes severe skin burns and eye damage 导致严重的皮肤灼伤和眼睛损伤
- H315 Causes skin irritation 会刺激皮肤
- H318 Causes serious eye damage 严重伤害眼睛
- H319 Causes serious eye irritation 严重刺激眼睛
- H332 Harmful if inhaled 吸入有害
- H335 May cause respiratory irritation 可能导致呼吸道刺激
- H336 May cause drowsiness or dizziness 肯能导致嗜睡或头晕
- H412 Harmfutoaquaticlifewithlonglastingeffects 对水生生物有害并具有长期影响。
|
Personal Protective Equipment |
Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
Hazard Codes |
3
F,C |
RTECS | JM9230000 |
Precautionary statements | |
- P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking. 远离热源/火花/明火/热的表面。——禁止吸烟。
- P233 Keep container tightly closed. ?保持容器密闭。
- P240 Ground/bond container and receiving equipment. 与地面接触/连接集装箱和接受设备。
- P241 Use explosion-proof electrical/ventilating/lighting/…/equipment. 使用防爆电气/通风/照明/ .../设备。
- P241+P242+P243
- P242 Use only non-sparking tools. 只能使用无火花工具。
- P243 Take precautionary measures against static discharge. 采取预防措施,防止静电放电。
- P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
- P264+P265
- P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西,喝水或吸烟。
- P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
- P273 Avoid release to the environment. 避免释放到环境中。
- P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
- P301+P312
- P301+P317
- P301+P330+P331
- P301+P330+P331+P310
- P302+P352
- P302+P361+P354
- P303+P361+P353
- P303+P361+P353+P310+P363
- P304+P312
- P304+P340
- P304+P340+P310
- P305+P351+P338
- P305+P351+P338+P310
- P305+P354+P338
- P307+P311
- P308+P311
- P308+P316
- P310 Immediately call a POISON CENTER or doctor/physician. 立即呼救解毒中心或医生/医师。
- P311 Call a POISON CENTER or doctor/physician. 呼叫解毒中心或医生/医师。
- P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适,呼叫解毒中心或医生/医师。
- P316
- P317
- P319
- P321 Specific treatment (see … on this label). 具体治疗(见本标签上的)。
- P322 Specific measures (see …on this label). 具体治疗(见本标签上的)。
- P330 Rinse mouth. 漱口
- P332+P317
- P337+P313
- P337+P317
- P361 Remove/Take off immediately all contaminated clothing. 立即去除/脱掉所有被污染的衣服。
- P361+P364
- P362+P364
- P363 Wash contaminated clothing before reuse. 被污染的衣服洗净后方可重新使用。
- P370+P378
- P403+P233
- P403+P235
- P405 Store locked up. 上锁保管。
- P501 Dispose of contents/container to..… 处理内容物/容器.....
|
Signal word |
Danger |
UN Number |
3286 |
Risk Statements | |
- R11 Highly flammable 非常易燃
- R20/21/22 Harmful by inhalation, in contact with skin and if swallowed 吸入、皮肤接触和不慎吞咽有害
- R34 Causes burns 会导致灼伤
- R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
- R52/53
|
Safety Statements | |
- S16 Keep away from sources of ignition - No smoking 远离火源,禁止吸烟;
- S20 When using do not eat or drink 使用时,不得进食,饮水;
- S23 Do not breathe gas/fumes/vapour/spray (appropriate wording to be specified by the manufacturer) 不要吸入气体/烟雾/蒸汽/喷雾;
- S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后,立即用大量水冲洗并征求医生意见;
- S33 Take precautionary measures against static discharges 对静电采取预防措施;
- S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套;
- S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护;
- S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时,立即求医(可能时出示标签);
- S60 This material and its container must be disposed of as hazardous waste 该物质及其容器必须作为危险废物处置;
- S61 Avoid release to the environment. Refer to special instructions/safety data sheet 避免释放到环境中,参考特别指示/安全收据说明书;
- S9 Keep container in a well-ventilated place 保持容器在通风良好的场所;
|
Storage condition |
Moisture Sensitive
密封保存
易潮解,密封保存
2-8°C |
Packing Group | II |
Hazard Class | 3/6.1, 8 |
Warnings |
危化品目录(2015) |
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 1 gm/kg/I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Lungs, Thorax, or Respiration - tumors
REFERENCE :
JNCIAM Journal of the National Cancer Institute. (Washington, DC) V.1-60,
1940-78. For publisher information, see JJIND8. Volume(issue)/page/year:
54,495,1975
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 800 mg/kg
TOXIC EFFECTS :
Behavioral - tremor
Behavioral - muscle weakness
Skin and Appendages - hair
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0537734
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 850 mg/kg
TOXIC EFFECTS :
Behavioral - general anesthetic
Cardiac - pulse rate
Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 30(5),52,1986
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 650 mg/kg
TOXIC EFFECTS :
Immunological Including Allergic - decreased immune response
REFERENCE :
StoGD# Personal Communication from G.D. Stoner, Dept. of Community Medicine,
School of Medicine, Univ. of California, La Jolla, CA 92037, May 25, 1975
Volume(issue)/page/year: 27MAY1975
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Rodent - guinea pig
DOSE/DURATION : 1 mL/kg
TOXIC EFFECTS :
Behavioral - tremor
Behavioral - muscle weakness
Skin and Appendages - hair
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
F
Restrict |
危险品 |
碱性硅烷化保护剂,无机填料处理剂
{uni_hamburg} Short: II/25D
{ALF} Can also function as a protected form of ammonia, e.g. to convert acid chlorides to primary amides: Synthesis, 517 (1985), and substituted maleic anhydrides to maleimides: Tetrahedron Lett., 31, 5201 (1990).
{ALF} For conversion of carbonyl groups to silyl enol ethers, see Iodotrimethyl­silane, A12902.
{ALF} Convenient, mild silylating reagent which generates gaseous ammonia as the only by-product (see Appendix 4). Non-acidic substrates normally require a catalyst.
{ALF} A range of catalysts for silylation with HMDS, including saccharin and sodium saccharin, has been recommended: J. Org. Chem., 47, 3966 (1982), for silylation of alcohols, phenols, thiols, carboxylic acids, amides, thioamides, hydroxamic acids, hydrazides, NH-groups of heterocycles, hydrazines, 1,3-diketones, etc. The use of TBAF (0.02 eq.) or iodine (0.01 eq.) also provide mild procedures for O-silylation: Tetrahedron Lett., 35, 8409 (1994); J. Org. Chem., 65, 7228 (2000).
{ALD} Merck: 14,4689
Beilstein: 4,IV,4014
{uni_hamburg} Short: III/35B
{ALF} Silylation of alcohols, including carbohydrates, is catalyzed by TMS chloride: J. Org. Chem., 23, 50 (1958); J. Am. Chem. Soc., 85, 2497 (1963); Chem. Ind. (London), 794 (1984). Silylation of phenols occurs readily, see also: Liebigs Ann. Chem., 20 (1973).
{ALF} The Na, Li and K derivatives are useful strong bases; see Sodium bis(trimethyl­silyl)­amide, L13352, Lithium bis(trimethyl­silyl)­amide, L15012, and Potassium bis(trimethyl­silyl)­amide, L15022.
{ALF} HMDS in the presence of TMS chloride permits the selective O-silylation of amino alcohols: Synthesis, 990 (1988). Alcohols and phenols can be silylated in the presence of amines and thiols with ZnCl2 as catalyst: Synth. Commun., 23, 1633 (1993).
{ALF} In combination with DMSO, thiols are oxidized to disulfides under nearly neutral conditions: Synlett, 346 (2002).
{ALD} Merck: 14,4689