Tris-(hydroxymethyl)-aminomethane, buffer substance, reagent grade, ACS 三(羟甲基)氨基甲烷

规格: buffer substance, reagent grade, ACS
CAS: 77-86-1
产品编号: TR04230250
MDL: MFCD00004679
品牌: Scharlab
Chemical NameTris(hydroxymethyl)aminomethane
CAS Number77-86-1
Alfabeta NameAMINOHYDROXYMETHYLPROPANEDIOL 2213()-----,
MDL NumberMFCD00004679
Synonym THAM {LY} THAM {} {LY} THAM {} {} {LY} THAM {} {} {} {LY} THAM {} {} {} {} {LY} THAM {} {} {} {} {} {LY} THAM {} {} {} {} {} {} {LY} THAM {} {} {} {} {} {} {} {LY} THAM {} {} {} {} {} {} {} {} {LY} THAM {} {} {} {} {} {} {} {} {} {LY} THAM {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} THAM {} {} {} {} {} {} {} {} {} {} {} {LY} THAM {} {} {} {} {} {} {} {} {} {} {} {} {LY} THAM {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} THAM {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} THAM {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} THAM {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} THAM {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} THAM {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} THAM
PubChem Substance ID6503
EC Number201-064-4
Beilstein Registry Number741883
Reaxys-RN741883
Merck Number9772
Chemical Name Translation三羟甲基氨基甲烷
Wiswesser Line NotationQ1XZ1Q1Q
LabNetwork Molecule IDLN00335089
InChIInChI=1S/C4H11NO3/c5-4(1-6,2-7)3-8/h6-8H,1-3,5H2
Canonical SMILESOCC(CO)(N)CO
GHS Symbol
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1210 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ABMGAJ Acta Biologica et Medica Germanica.  (Berlin, Ger. Dem. Rep.) V.1-41,
   1958-82.  For publisher information, see BBIADT. Volume(issue)/page/year:
   17,217,1966

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 1 gm/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - muscle weakness
   Behavioral - coma
REFERENCE :
   JIHTAB Journal of Industrial Hygiene and Toxicology.  (Cambridge, MA)
   V.18-31, 1936-49.  For publisher information, see AEHLAU.
   Volume(issue)/page/year: 22,315,1940

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 5900 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   BCFAAI Bollettino Chimico Farmaceutico.  (Societa Editoriale Farmaceutica,
   Via Ausonio 12, 20123 Milan, Italy)  V.33-    1894- Volume(issue)/page/year:
   110,653,1971

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1800 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NIIRDN Drugs in Japan (Ethical Drugs).  (Yakugyo Jiho Co., Ltd., Tokyo,
   Japan)  Volume(issue)/page/year: -,419,1990

Warnings IRRITANT
WGK Germany2
Hazard Codes Xi Xi,N,C,F+,F
Hazard statements
  • H315 Causes skin irritation 会刺激皮肤
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
    Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves Eyeshields, Gloves
    RTECSTY2900000
    Precautionary statements
    • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
    • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
    • P264+P265
    • P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
    • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
    • P302+P352
    • P302+P352+P332+P313+P362+P364
    • P304+P340
    • P305+P351+P338
    • P305+P351+P338+P337+P313
    • P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适，呼叫解毒中心或医生/医师。
    • P319
    • P321 Specific treatment (see … on this label). 具体治疗（见本标签上的）。
    • P332+P313
    • P332+P317
    • P337+P313
    • P337+P317
    • P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服，清洗后方可重新使用
    • P362+P364
    • P403+P233
    • P405 Store locked up. 上锁保管。
    • P501 Dispose of contents/container to..… 处理内容物/容器.....
      Signal word Warning
      Safety Statements
      • S16 Keep away from sources of ignition - No smoking 远离火源，禁止吸烟；
      • S18 Handle and open container with care 小心搬运和开启容器；
      • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
      • S36 Wear suitable protective clothing 穿戴适当的防护服；
      • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
      • S37 Wear suitable gloves 戴适当手套；
      • S37/39 Wear suitable gloves and eye/face protection 穿戴适当的手套和眼睛/面保护；
      • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
      • S60 This material and its container must be disposed of as hazardous waste 该物质及其容器必须作为危险废物处置；
      • S61 Avoid release to the environment. Refer to special instructions/safety data sheet 避免释放到环境中，参考特别指示/安全收据说明书；
        Risk Statements
        • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
          Storage condition 2-8°C {LY} 2-8°C Hygroscopic {} {LY} 2-8°C {} {} {LY} 2-8°C {} {} {} {LY} 2-8°C {} {} {} {} {LY} 2-8°C {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {
          Packing GroupII
          Hazard Class3
          UN Number
        • 生物缓冲剂，缓冲范围pH7.0-9.0。酸性气体吸收剂。酸量滴定法基准物质。电流滴定法测定蛋白质中的巯基。纸上电泳分离血清蛋白。淀粉平板电泳分离毒素。
        • {ALD} Merck: 14,9772
        • Beilstein: 4,IV,1903
        • {uni_hamburg} Short: IV/4
        • {SA} Santoni, V., et al. Electrophoresis 21 , 1054, (2000) 摘要
        • {ALD} Merck: 14,9772
        • {uni_hamburg} Short: III/5a
        • {ALFA} Widely used biological buffer.
        • {uni_hamburg} Short: IV/8A
        • {SA} Merck 14 ,9772
          • 77-86-1 TR04230250 Tris-(hydroxymethyl)-aminomethane, buffer substance, reagent grade, ACS 三(羟甲基)氨基甲烷

          化学属性

          Mol. FormulaC4H11NO3
          Mol. Weight121.14
          Boiling Point219-220 °C at 10 mmHg
          Melting Point167-172°C
          Density1.353
          TSCAYes
          Solubility550 G/L (25 ºC)
          Flash Point732°C
          Appearance 白色结晶或粉末。熔点171-172℃ ，沸点219-220℃ /1.3kPa，溶于乙醇和水，微溶于乙酸乙酯、苯、不溶于乙醚、四氯化碳，对铜、铝有腐蚀作用，有刺激性。 crystalline
          Stability对湿度敏感

          *以上化合物性质及应用等信息仅供参考