Acetic acid, eluent additives for LC-MS 乙酸,LC-MS添加物

规格: eluent additives for LC-MS
CAS: 64-19-7
产品编号: AC03470050
MDL: MFCD00036152
品牌: Scharlab
Chemical NameAcetic acid glacial
Synonym Acetic acid, glacial Azijnzuur Essigsaeure Glacial acetic acid Octowy kwas Vinegar acid 乙酸 乙酸 溶液 乙酸添加剂 冰醋酸;乙酸 醋酸36%
CAS Number64-19-7
PubChem Substance ID176
EC Number200-580-7
Beilstein Registry Number2(4)94
MDL NumberMFCD00036152
Merck Number55
Chemical Name Translation冰乙酸
InChIKeyQTBSBXVTEAMEQO-UHFFFAOYSA-N
Reaxys-RN506007
Wiswesser Line NotationQV1
LabNetwork Molecule IDLN00162861
InChIInChI=1S/C2H4O2/c1-2(3)4/h1H3,(H,3,4)
GHS Symbol
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Rectal
SPECIES OBSERVED        : Human - child
DOSE/DURATION           : 281 uL/kg
TOXIC EFFECTS :
   Gastrointestinal - alteration in gastric secretion
   Liver - liver function tests impaired
   Kidney, Ureter, Bladder - changes in tubules (including acute renal failure,
   acute tubular necrosis)
REFERENCE :
   JTCTDW Journal of Toxicology, Clinical Toxicology.  (Marcel Dekker, 270
   Madison Ave., New York, NY 10016)  V.19-    1982-  Volume(issue)/page/year:
   82,333,1994

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent -

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 3310 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   DMDJAP Delaware State Medical Journal.  (Wilmington, DE)  V.1-32(1),
   1929-60.  For publisher information, see DSMJAA.  Volume(issue)/page/year:
   31,276,1959

TYPE OF TEST            : LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 5620 ppm/1H
TOXIC EFFECTS :
   Sense

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 525 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
REFERENCE :
   APTOA6 Acta Pharmacologica et Toxicologica.  (Copenhagen, Denmark)  V.1-59,
   1945-86.  For publisher information, see PHTOEH  Volume(issue)/page/year:
   18,141,1961

TYPE OF TEST            : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE       :

TYPE OF TEST            : Unscheduled DNA synthesis
ROUTE OF EXPOSURE       : Administration onto the skin
TEST SYSTEM             : Rodent - mouse
DOSE/DURATION           : 79279 ug/kg
REFERENCE :
   JNCIAM Journal of the National Cancer Institute.  (Washington, DC)  V.1-60,
   1940-78.  For publisher information, see JJIND8.  Volume(issue)/page/year:
   55,983,1975

TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Rodent - hamster Ovary
DOSE/DURATION           : 10 mmol/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 240,195,1990

TYPE OF TEST            : Sister chromatid exchange
TEST SYSTEM             : Human Lymphocyte
DOSE/DURATION           : 5 mmol/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 279,75,1992

{hazar

TYPE OF TEST            : Sex chromosome loss and nondisjunction
ROUTE OF EXPOSURE       : Inhalation
TEST SYSTEM             : Insect - Drosophila melanogaster
DOSE/DURATION           : 1000 ppm/24H
REFERENCE :
   THAGA6 Theoretical & Applied Genetics.  (Springer-Verlag New York, Inc.,
   Service Center, 44 Hartz Way, Secaucus, NJ 07094)  V.38-    1968-
   Volume(issue)/page/year: 39,330,1969

TYPE OF TEST

TYPE OF TEST            : Cytogenetic analysis
ROUTE OF EXPOSURE       : Parenteral
TEST SYSTE

TYPE OF TEST            : Mutation test systems - not otherwise specified
ROUTE OF EXPOSURE       : Administration onto the skin
TEST SYSTEM             : Rodent - mouse
DOSE/DURATION           : 1201 mg/kg
REFERENCE :
   JNCIAM Journal of the National Cancer Institute.  (Washington, DC)  V.1-60,
   1940-78.  For publisher information, see JJIND8.  Volume(issue)/page/year:
   55,983,1975

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intratesticular
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 400 mg/kg
SEX/DURATION            : male 1 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Fertility - male fertility index (e.g. # males impregnating
   females per # males exposed to fertile nonpregnant females)
REFERENCE :
   FESTAS Fertility and Sterility.  (American Fertility Soc., 608 13th Ave. S,
   Birmingham, AL 35282) V.1-    1950-  Volume(issue)/page/year: 24,884,1973

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 700 mg/kg
SEX/DURATION            : lactating female 18 day(s) post-birth
TOXIC EFFECTS :
   Reproductive - Effects on Newborn - behavioral
REFERENCE :
   NTOTDY Neurobehavioral Toxicology and Teratology.  (Fayetteville, NY) V.3-8,
   1981-86.  For publisher information, see NETEEC. Volume(issue)/page/year:
   4,105,1982

WGK Germany1
Hazard Codes 8 C
Hazard statements
  • H226 Flammable liquid and vapour 易燃液体和蒸气
  • H314 Causes severe skin burns and eye damage 导致严重的皮肤灼伤和眼睛损伤
  • H315 Causes skin irritation 会刺激皮肤
  • H319 Causes serious eye irritation 严重刺激眼睛
    Personal Protective Equipment Faceshields, Gloves, Goggles Eyeshields, Gloves Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
    RTECSAF1225000
    Precautionary statements
    • P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking. 远离热源/火花/明火/热的表面。——禁止吸烟。
    • P233 Keep container tightly closed. ?保持容器密闭。
    • P234 Keep only in original container. 只保留在原来的容器中。
    • P240 Ground/bond container and receiving equipment. 与地面接触/连接集装箱和接受设备。
    • P241+P242+P243
    • P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
    • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
    • P273 Avoid release to the environment. 避免释放到环境中。
    • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
    • P301+P330+P331+P310
    • P302+P352
    • P303+P361+P353
    • P303+P361+P353+P310+P363
    • P304+P340
    • P304+P340+P310
    • P305+P351+P338
    • P305+P351+P338+P310
    • P309+P311
    • P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适,呼叫解毒中心或医生/医师。
    • P390 Absorb spillage to prevent material damage. 吸收溢出物,防止重大损害。
    • P403+P235
    • P405 Store locked up. 上锁保管。
    • P406 Store in corrosive resistant/… container with a resistant inner liner. 存放在耐腐蚀/具有耐性的内衬容器。
    • P501 Dispose of contents/container to..… 处理内容物/容器.....
      Signal word Danger
      UN Number 2789 UN2789
      Risk Statements
      • R10 Flammable 易燃
      • R34 Causes burns 会导致灼伤
      • R35 Causes severe burns 会导致严重灼伤
        Safety Statements
        • S23 Do not breathe gas/fumes/vapour/spray (appropriate wording to be specified by the manufacturer) 不要吸入气体/烟雾/蒸汽/喷雾;
        • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后,立即用大量水冲洗并征求医生意见;
        • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时,立即求医(可能时出示标签);
          Packing GroupII
          Storage condition 密封,在16℃以上的暖处保存,以防凝固而致使容器破裂 室温储存 充氩保存
          Hazard Class8/3
          Warnings 危化品目录(2015)
        • 常用有机酸。分析、溶剂、有机合成,制备缓冲液等。
        • {ALD} Merck: 14,55
        • {ALD} Merck: 14,55
        • Beilstein: 2,IV,94
        • 64-19-7 AC03470050 Acetic acid, eluent additives for LC-MS	乙酸,LC-MS添加物

          化学属性

          Mol. FormulaCH3CO2H
          Mol. Weight60
          Refractive indexn20/D 1.371(lit.)
          Boiling Point117-118
          Density1.048
          Melting Point16-17
          Flash Point41°C(lit.)
          TSCAYes
          Autoignition Point800 °F
          Vapor Density2.07 (vs air)
          Vapor Pressure15.2 hPa ( 20.0 °C)
          SolubilitySoluble in water, ethanol, ether, glycerol, most organic solvents, and carbon tetrachloride. Insoluble in carbon disulfide.
          Stability对湿度敏感