Lithium bis(trimethylsilyl)amide 双(三甲基硅基)氨基锂

规格: 1.0 M solution in THF, SpcSeal
CAS: 4039-32-1
产品编号: H12010
MDL: MFCD00008261
品牌: INFI
Chemical NameLithium bis(trimethylsilyl)amide
CAS Number4039-32-1
EC Number223-725-6
Beilstein Registry Number3567910
MDL NumberMFCD00008261
Synonym (LiN(SiMe3)2) Li bis(TMS)A Lithium Bis(trimethylsilyl)amide (ca. 26% in Tetrahydrofuran, ca. 1.3mol/L) lithium bis(trimethylsilyl)amide {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {PubChem} lithium bis(trimethylsilyl)amide {} {} {} {} {} {} {} {} {} {LY} Lithium bis(trimethylsilyl)amine,1.0M solution in THF,Safeseal {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Lithium bis(trimethylsilyl)amine,1.0M solution in THF,Safeseal {} {} {} {} {} {} {} {} {} {} {} {} {LY} Lithium bis(trimethylsilyl)amine,1.0M solution in THF,Safeseal {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Lithium bis(trimethylsilyl)amine,1.0M solution in THF,Safeseal {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Lithium bis(trimethylsilyl)amine,1.0M solution in THF,Safeseal {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Lithium bis(trimethylsilyl)amine,1.0M solution in THF,Safeseal
PubChem Substance ID57426343
Reaxys-RN8136861
Chemical Name Translation双(三甲基硅基)氨基锂
InChIKeyYNESATAKKCNGOF-UHFFFAOYSA-N
LabNetwork Molecule IDLN00162852
InChIInChI=1S/C6H19NSi2.Li/c1-8(2,3)7-9(4,5)6;/h7H,1-6H3;
Canonical SMILESC[Si]([N-][Si](C)(C)C)(C)C.[Li+]
  • ⑴.也称二(三甲基硅基)氨基锂。熔点71～72℃。沸点114～116℃(133.322Pa)。自燃，惰气保护下密封贮运。对空气与水敏感。以硅氨在乙醚中与金属锂反应而得。
  • ⑵.用于醛醇缩合，是常用的有机碱。例如形成乙炔化锂，或者制备烯醇锂盐。
  • ⑶. 双(三甲基硅基)氨基锂可用于制备低配位数的配合物，因为配体(TMS)2N-的位阻很大。这样的例子有M[N(TMS)2]3（M = Sc, Ti, V, Fe ；TMS = (CH3)3Si)）。与三甲基氯硅烷反应产生三(三甲基硅基)胺，其中氮的配位数为3，空间构
  • 非亲核性强碱，可用于形成烯醇的反应，烯醇酯立体专一克莱森重排反应，将醛转化为硅亚胺的反应，生成缩水甘油酸酯的反应，β内酰胺的反应，芳基烷基醚的选择性断裂反应。
  • {ALF} Supplied in septum cap bottle.
  • {ALF} Versatile non-nucleophilic strong base. For examples of use in the lithiation of ethyl acetate, see: Org. Synth. Coll., 6, 598 (1988), and in the stereospecific Wadsworth-Emmons synthesis of fluoroalkenes from (E)- and (Z)-fluorovinyl sulfones: Org. Synth. Coll., 9, 442 (1998).
    • 4039-32-1 H12010 Lithium bis(trimethylsilyl)amide 双(三甲基硅基)氨基锂

    化学属性

    Mol. FormulaC6H18LiNSi2
    Mol. Weight167.33
    Density0.9
    Boiling Point55 - 56 °C
    Flash Point-17 °C - (闭杯)
    TSCAYes
    Melting Point70 - 76 °C
    Solubility水解
    Refractive indexn20/D 1.425(lit.)
    Stability对空气和湿度敏感
    Danger-Level甲类
    pH-:-
    Redox-

    *以上化合物性质及应用等信息仅供参考