beta-Estradiol beta-雌二醇

规格: 97%
CAS: 50-28-2
产品编号: H20723
MDL: MFCD00003693
品牌: INFI
Chemical NameEstradiol
Synonym β-雌二醇 1,3,5-Estratriene-3,17beta-diol; 17beta-Estradiol; 3,17beta-Dihydroxy-1,3,5(10)-estratriene; Dihydrofolliculin 1,3,5-雌甾三烯-3,17β-二醇 17β-雌二醇 3,17β-二羟基-1,3,5(10)-雌甾三烯 雌二醇 17 beta Estradiol 17 beta Oestradiol 17 beta-Estradiol 17 beta-Oestradiol 17β-雌二醇 3,17-beta-Dihydroxyestra-1,3,5(10)-triene 3,17β-二羟基-1,3,5(10)-雌甾三烯 Aerodiol Altrad Delestrogen Dihydrofollicular hormone Dihydrofolliculin Dihydromenformon Dihydrotheelin Estrace Estraderm TTS Estradiol Estradiol 17 alpha Estradiol 17 beta Estradiol 17beta Estradiol Anhydrous Estradiol Hemihydrate Estradiol Hemihydrate, (17 alpha)-Isomer Estradiol Monohydrate Estradiol, (+-)-Isomer Estradiol, (-)-Isome
MDL NumberMFCD00003693
CAS Number50-28-2
PubChem Substance ID5757
EC Number200-023-8
Beilstein Registry Number1914275
Reaxys-RN1914275
Merck Number3703
Chemical Name Translation雌二醇
Wiswesser Line NotationL E5 B666TTT&J E1 FQ OQ
LabNetwork Molecule IDLN00235694
InChIInChI=1S/C18H24O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3,5,10,14-17,19-20H,2,4,6-9H2,1H3/t14-,15-,16+,17+,18+/m1/s1
GHS Symbol
TYPE OF TEST            : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE       : Implant
SPECIES OBSERVED        : Rodent - hamster
DOSE/DURATION           : 160 mg/kg
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Kidney, Ureter, Bladder - tumors
   Lungs, Thorax, or Respiration - bronchiogenic carcinoma
REFERENCE :
   CANCAR Cancer (Philadelphia).  (Lippincott/Harper, Journal Fulfillment
   Dept., 2350 Virginia Ave., Hagerstown, MD 21740)  V.1-    1948-
   Volume(issue)/page/year: 10,757,1957

TYPE OF TEST            : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE       : Implant
SPECIES OBSERVED        : Rodent - guinea pig
DOSE/DURATION           : 40 mg/kg
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Reproductive - Tumorigenic effects - uterine tumors
REFERENCE :
   LANCAO Lancet.  (7 Adam St., London WC2N 6AD, UK)  V.1-    1823-
   Volume(issue)/page/year: 1,1313,1939

TYPE OF TEST

TYPE OF

TYPE OF TEST            : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 44 mg/kg/52W-I
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Skin and Appendages - tumors
   Tumorigenic - tumor types after systemic administration not seen
   spontaneously
REFERENCE :
   JEPTDQ Journal of Environmental Pathology and Toxicology.  (Park Forest
   South, IL)  V.1-5(3), 1977-81(?).  For publisher information, see JEPOEC.
   Volume(issue)/page/year: 1(1),1,1977

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - guinea pig
DOSE/DURATION           : 7 mg/kg/12W-I
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Reproductive - Tumorigenic effects - ut

{

WGK Germany3
Hazard Codes T
Hazard statements
  • H351 Suspected of causing cancer 怀疑致癌
  • H362 May cause harm to breast-fed children 可能对母乳喂养的婴儿造成伤害
  • H360 May damage fertility or the unborn child 可能对生育能力或未出生婴儿造成伤害
  • H350 May cause cancer 可能致癌
    Personal Protective Equipment Eyeshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges Eyeshields, Gloves, type P2 (EN 143) respirator cartridges
    RTECSKG2975000
    Precautionary statements
    • P501 Dispose of contents/container to..… 处理内容物/容器.....
    • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
    • P305+P351+P338
    • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
    • P201 Obtain special instructions before use. 使用前获取专门指示。
    • P405 Store locked up. 上锁保管。
    • P308+P313
    • P281 Use personal protective equipment as required. 使用所需的个人防护装备。
    • P263 Avoid contact during pregnancy/while nursing. 怀孕/哺乳期间避免接触。
    • P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前,切勿操作。
      Signal word
      Safety Statements
      • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时,立即求医(可能时出示标签);
      • S53 Avoid exposure - obtain special instructions before use 避免接触,使用前获得特别指示说明;
      • S20 When using do not eat or drink 使用时,不得进食,饮水;
      • S36 Wear suitable protective clothing 穿戴适当的防护服;
      • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后,立即用大量水冲洗并征求医生意见;
      • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护;
      • S60 This material and its container must be disposed of as hazardous waste 该物质及其容器必须作为危险废物处置;
        UN Number
        Risk Statements
          Packing GroupIII
          Storage condition 室温、干燥、密封保存。 储存温度2-8℃
        • 经前期卵巢分泌的只要雌激素。在青春期靠调控基因转录和蛋白质合成指导雌性表现型和胚胎的发育,也诱导促性腺激素的生成,诱导排卵。
        • {ALD} Merck: 14,3703
        • {ALD} Merck: 14,3703
        • Beilstein:6(3)5337
        • 50-28-2 H20723 beta-Estradiol
beta-雌二醇

          化学属性

          Mol. FormulaC18H24O2
          Mol. Weight272
          Melting Point176-180
          TSCANo
          Density1.17
          Stability对光线敏感