Tetrachloroethylene 四氯乙烯

规格: 99%, SpcDry, Water≤50 ppm (by K.F.), SpcSeal
CAS: 127-18-4
产品编号: H58133
MDL: MFCD00000834
品牌: INFI
Chemical NameTetrachloroethylene 四氯乙烯
Synonym 1,1,2,2-Tetrachloroethene 1,1,2,2-Tetrachloroethylene 1,1,2,2-Tetrachloroethylene; Perchloroethylene Ankilostin Antisal 1 Carbon bichloride Didakene Dow-per Ethylene, tetrachloro- Ethylentetrachlorid Fedal-Un PCE 全氯乙烯 四氯乙烯 PerSec Perawin Perchlor Perchloroethylene Persec TETRACHLOROETHENE Tetracap Tetrachloor Tetrachloraethen Tetrachloräthylen Tetralex Tetravec ai3-01860 perchloroethylene tetrachloroethene tetrachloroethylene {} {} {} {} {} {} {} {} {hazard_c 四氯乙烯 063-01 [6] 密度标准品 1623kg/m3 过氯乙烯
CAS Number127-18-4
PubChem Substance ID31373
EC Number204-825-9
Beilstein Registry Number1361721
MDL NumberMFCD00000834
Reaxys-RN1304635
Merck Number14,9190
Chemical Name Translation四氯乙烯
Wiswesser Line NotationGYGUYGG
LabNetwork Molecule IDLN00162756
InChIInChI=1S/C2Cl4/c3-1(4)2(5)6
GHS Symbol
TYPE OF TEST            : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 100 ppm/6H/2Y-I
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Liver - tumors
REFERENCE :
   NTPTR* National Toxicology Program Technical Report Series.  (Research
   Triangle Park, NC 27709) No.206-  Volume(issue)/page/year: NTP-TR-311,1986

TYPE OF TEST            : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 240 gm/kg/62W-I
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Liver - tumors
REFERENCE :
   NCITR* National Cancer Institute Carcinogenesis Technical Report Series.
   (Bethesda, MD)  No.0-205. For publisher information, see NTPTR*.
   Volume(issue)/page/year: NCI-TR-13,1977

TYPE OF TEST            : TC - Toxic concentration (other than lowest)
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 200 ppm/6H/2Y-I
TOXIC EFFECTS :
   Tumorigenic - neoplastic by RTECS criteria
   Kidney, Ureter, Bladder - Kidney tumors
   Blood - leukemia
REFERENCE :
   TOLED5 Toxicology Letters.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1977-  Volume(issue)/page/year:
   31(Suppl),16,1986

TYPE OF TEST            : TC - Toxic concentration (other than lowest)
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 100 ppm/6H/2Y-I
TOXIC EFFECTS :
   Tumorigenic - neoplastic by RTECS criteria
   Liver - tumors
REFERENCE :
   TOLED5 Toxicology Letters.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1977-  Volume(issue)/page/year:
   31(Suppl),16,1986

TYPE OF TEST

TYPE OF TEST            : TDLo -

TYPE OF TEST            : LDLo - Lowest publi

TYPE OF TEST            : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Human - man
DOSE/DURATION           : 600 ppm/10M
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - conjunctive irritation
   Behavioral - general anesthetic
REFERENCE :
   AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine.
   (Chicago, IL)  V.2-10, 1950-54. For publisher information, see AEHLAU.
   Volume(issue)/page/year: 5,566,1952

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Mammal - cat
DOSE/DURATION           : 4 gm/kg
TOXIC EFFECTS :
   Behavioral - sleep
   Behavioral - somnolence (general depressed activity)
REFERENCE :
   AJHYA2 American Journal of Hygiene.  (Baltimore, MD)  V.1-80, 1921-64.  For
   publisher information, see AJEPAS.  Volume(issue)/page/year: 9,430,1929

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 4678 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ENVRAL Environmental Research.  (Academic Press, Inc., 1 E. First St.,
   Duluth, MN 55802) V.1-    1967-  Volume(issue)/page/year: 40,411,1986

TYPE OF TEST            :

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 2100 mg/kg
TOXIC EFFECTS :
   Liver - liver function tests impaired
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   10,119,1967

TYPE OF TEST            : LD50 - Le

TYPE OF TEST            : Sex chromosome loss and nondisjunction
TEST SYSTEM             : Rodent - hamster Lung
DOSE/DURATION           : 190 umol/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 182,135,1987

TYPE OF TEST            : Unscheduled DNA synthesis
TEST SYSTEM             : Human Lung
DOSE/DURATION           : 100 mg/L
REFERENCE :
   NTIS** National Technical Information Service.  (Springfield, VA 22161)
   Formerly U.S. Clearinghouse for Scientific & Technical Information.
   Volume(issue)/page/year: PB82-185075

TYPE OF TEST            : Sperm Morphology
ROUTE OF EXPOSURE       : Inhalation
TEST SYSTEM             : Rodent - mouse
DOSE/DURATION           : 500 ppm
REFERENCE :
   NTIS** National Technical Information Service.  (Springfield, VA 22161)
   Formerly U.S. Clearinghouse for Scientific & Technical Information.
   Volume(issue)/page/year: PB82-185075

TYPE OF TEST            : Morphological transformation
TEST SYSTEM             : Rodent - rat Embryo
DOSE/DURATION           : 97 umol/L
REFERENCE :
   ITCSAF In Vitro.  (Rockville,

TYPE OF TEST            : Cytogenetic analysis
ROUTE OF EXPOSURE       : Inhalation
TEST SYSTEM             : Rodent - rat
DOSE/DURATION           : 500 ppm
REFERENCE :
   NTIS** National Technical Information Service.  (Springfield, VA 22161)
   Formerly U.S. Clearinghouse for Scientific & Technical Information.
   Volume(issue)/page/year: PB82-185075

TYPE OF TEST            : Host-mediated assay
TEST SYSTEM             : Rodent - mouse Bacteria - Salmonella typhimurium
DOSE/DURATION           : 100 ppm
REFERENCE :
   NTIS** National Technical Information Service.  (Springfield, VA 22161)
   Formerly U.S. Clearinghouse for Scientific & Technical Information.
   Volume(issue)/page/year: PB82-185075

TYPE OF TEST            : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 1000 ppm/24H
SEX/DURATION            : female 14 day(s) pre-mating
                          female 1-22 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
   APTOD9 Abstracts of Papers, Society of Toxicology.  Annual Meetings.
   (Academic Press, Inc., 1 E. First St., Duluth, MN 55802)
   Volume(issue)/page/year: 19,A21,1980

TYPE OF TEST            : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 500 ppm/7H
SEX/DURATION            : male 5 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Paternal Effects - spermatogenesis (incl. genetic material,
   sperm morphology, motility, and count)
REFERENCE :
   NTIS** National Technical Information Service.  (Springfield, VA 22161)
   Formerly U.S. Clearinghouse for Scientific & Technical Information.
   Volume(issue)/page/year: PB82-185075

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TYPE OF TEST            : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE       : Inha

TYPE OF TEST            : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 900 ppm/7H
SEX/DURATION            : female 7-13 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Newborn - live birth index (measured after birth)
   Reproductive - Effects on Newborn - biochemical and metabolic
   Reproductive - Effects on Newborn - behavioral
REFERENCE :
   TJADAB Teratology, The International Journal of Abnormal Development. (Alan
   R. Liss, Inc., 41 E. 11th St., New York, NY 10003)  V.1-    1968-
   Volume(issue)/page/year: 19,41A,1979

WGK Germany3
Hazard Codes 6.1 Xn;N
Hazard statements
  • H351 Suspected of causing cancer 怀疑致癌
  • H411 Toxictoaquaticlifewithlonglastingeffects 对水生生物有毒性并具有长期影响。
  • H315 Causes skin irritation 会刺激皮肤
  • H225 Highly flammable liquid and vapour 高度易燃液体和蒸气
    Personal Protective Equipment Eyeshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
    RTECSKX3850000
    Precautionary statements
    • P201 Obtain special instructions before use. 使用前获取专门指示。
    • P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前,切勿操作。
    • P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking. 远离热源/火花/明火/热的表面。——禁止吸烟。
    • P233 Keep container tightly closed. ?保持容器密闭。
    • P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
    • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
    • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
    • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西,喝水或吸烟。
    • P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
    • P273 Avoid release to the environment. 避免释放到环境中。
    • P281 Use personal protective equipment as required. 使用所需的个人防护装备。
    • P303+P361+P353
    • P304+P340
    • P305+P351+P338
    • P308+P313
    • P337+P313
    • P403+P233
    • P405 Store locked up. 上锁保管。
    • P501 Dispose of contents/container to..… 处理内容物/容器.....
      Signal word Warning
      Safety Statements
      • S23 Do not breathe gas/fumes/vapour/spray (appropriate wording to be specified by the manufacturer) 不要吸入气体/烟雾/蒸汽/喷雾;
      • S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套;
      • S61 Avoid release to the environment. Refer to special instructions/safety data sheet 避免释放到环境中,参考特别指示/安全收据说明书;
        Risk Statements
        • R40 Limited evidence of a carcinogenic effect 有限证据表明其致癌作用
        • R51/53
          Storage condition 0-10 0-10°C 储存温度2-8℃ 0-6°C 密封避光保存。
          UN Number 1897 UN 1897 6.1/PG 3 UN1897
          Packing GroupIII
          Hazard Class3/6.1
          Warnings 危化品目录(2015)
        • 有机分析中用作脂肪或脂肪类似物质的溶剂。高压液 相色谱试剂。分光光度测定用溶剂。有机合成。
        • {ALD} Merck: 14,9190
        • {uni_hamburg} Short: II/27B
        • {uni_hamburg} Short: II/25B
        • {ALD} Merck: 14,9190
        • Beilstein: 1,IV,715
        • 127-18-4 H58133 Tetrachloroethylene
四氯乙烯

          化学属性

          Mol. FormulaC2Cl4
          Mol. Weight166
          Refractive indexn20/D 1.505(lit.)
          Boiling Point120-122
          Density1.625
          Melting Point-22
          TSCAYes
          Vapor Density5.83 (vs air)
          Vapor Pressure13 mmHg ( 20 °C)
          Flash Point120-121°C
          Solubility不溶于水,可混溶于乙醇、乙醚等多数有机溶剂。
          Stability对光敏感