Tetramethylammonium chloride 四甲基氯化铵

规格: 99%
CAS: 75-57-0
产品编号: H80196
MDL: MFCD00011628
品牌: INFI
Chemical NameTetramethyl ammonium chloride
MDL NumberMFCD00011628
PubChem Substance ID6379
CAS Number75-57-0
Reaxys-RN3911201
Beilstein Registry Number3911201
EC Number200-880-8
Synonym TMA TMACL Tetrabutyl-ammonium Chloride(TMAC) TetramethylAmmoniumChlorideForSynthesis Tetramethylammonium chloride, 98+% Tetramethylammonium chloride; N,N,N-trimethylmethanaminium chloride; TMAC Tetramethylammoniumchloride,97%,maycont.ca3%silicaasanticakingagent n,n,n-trimethyl-methanaminiuchloride tetramethyl-ammonium chloride usafan-8 四甲基氯化铵 四甲基氯化铵 溶液 四甲基氯化铵, 97%, 可能大约含3% 硅胶作抗凝剂 氯化四甲
Chemical Name Translation四丁基氟化铵*SJJLHA
Wiswesser Line Notation1K1&1&1 &G
LabNetwork Molecule IDLN00195336
InChIInChI=1S/C4H12N.ClH/c1-5(2,3)4;/h1-4H3;1H/q+1;/p-1
GHS Symbol
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 125 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JPMSAE Journal of Pharmaceutical Sciences.  (American Pharmaceutical Assoc.,
   2215 Constitution Ave., NW, Washington, DC 20037)  V.50-    1961-
   Volume(issue)/page/year: 69,327,1980

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 25 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NTIS** National Technical Information Service.  (Springfield, VA 22161)
   Formerly U.S. Clearinghouse for Scientific & Technical Information.
   Volume(issue)/page/year: AD414-344

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 6 mg/kg
TOXIC EFFECTS :
   Vascular - BP lowering not characterized in autonomic section
   Lungs, Thorax, or Respiration - other changes
REFERENCE :
   AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans
   Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium)  V.4-   
   1898-  Volume(issue)/page/year: 7,183,1900

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 20 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - ataxia
   Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
   AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans
   Institute of Pharmacology, De Pintelaan 185, B-9000 Gh

Personal Protective Equipment Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
WGK Germany1
Precautionary statements
  • P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西,喝水或吸烟。
  • P273 Avoid release to the environment. 避免释放到环境中。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P301+P310
  • P301+P310+P330
  • P302+P352+P312
  • P302+P352+P312+P362+P364
  • P305+P351+P338
  • P305+P351+P338+P337+P313
  • P308+P311
  • P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适,呼叫解毒中心或医生/医师。
  • P332+P313
  • P405 Store locked up. 上锁保管。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
    Signal word Danger
    Hazard statements
    • H315 Causes skin irritation 会刺激皮肤
    • H335 May cause respiratory irritation 可能导致呼吸道刺激
    • H319 Causes serious eye irritation 严重刺激眼睛
    • H311 Toxic in contact with skin 皮肤接触中毒
    • H300 Fatal if swallowed 吞食致命
    • H301+H311
      Hazard Codes 6.1 T T,N
      RTECSBS7700000
      UN Number 2811 UN 2811 6.1/PG 2
      Safety Statements
      • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后,立即用大量水冲洗并征求医生意见;
      • S28 After contact with skin, wash immediately with plenty of ... (to be specified by the manufacturer) 皮肤接触后,立即用大量…(由生产厂家指定)冲洗;
      • S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套;
      • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护;
      • S37/39 Wear suitable gloves and eye/face protection 穿戴适当的手套和眼睛/面保护;
      • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时,立即求医(可能时出示标签);
        Risk Statements
        • R21 Harmful in contact with skin 与皮肤接触有害
        • R24/25 Toxic in contact with skin and if swallowed 皮肤接触及吞食都有毒
        • R25 Toxic if swallowed 吞咽有毒
        • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
        • R38 Irritating to skin 刺激皮肤
        • R39/25 Toxic: danger of very serious irreversible effects if swallowed 毒性:吞食会产生十分严重的不可逆危险
        • R51/53
          Storage condition Store at RT. 密封干燥保存。 Hygroscopic
          Packing GroupII
          Hazard Class6.1
        • 极谱分析试剂。
        • {ALF} Compare also Tetraphenyl­phosphonium bromide, A15860 and Tetraphenyl­phosphonium chloride, A10575.
        • {uni_hamburg} Short: II/5
        • {ALD} Beilstein:4(4)145
        • {ALF} Thermally-stable phase-transfer catalyst (see Appendix 2) which has been used in nucleophilic displacement reactions of aryl nitro groups with KF in tetramethylene sulfone: J. Org. Chem., 56, 6406 (1991). A detailed study of the halex Cl - /F - exchange reaction of activated aryl chlorides, for example the conversion of 1,2-dichloro-4-nitrobenzene to 2-chloro-1-fluoro-4-nitrobenzene in DMSO at 120oC showed tetramethylammonium chloride to be superior to other common phase-transfer catalysts. It was necessary to pre-dry the catalyst to <;0.2% water to avoid competition from hydrolytic displacement: Chem. Commun., 297 (1996).
        • 75-57-0 H80196 Tetramethylammonium chloride
四甲基氯化铵

          化学属性

          Mol. FormulaC4H12ClN
          Mol. Weight110
          Melting Point>300
          Density1.17
          TSCAYes
          Solubility>60 G/100 ML (20 ºC)
          Appearance 白色结晶性粉末, 熔点 420°C ,水溶性 >;60 g/100 mL (20°C)