| Chemical Name | Pyridine hydrofluoride |
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| CAS Number | 62778-11-4 |
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| Alfabeta Name | HYDROGENFLUORIDEPYRIDINEHF %70()- |
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| MDL Number | MFCD00012436 |
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| Synonym |
HF-Pyridine, Pyridine hydrofluoride
HF-Pyridine, Olah′s reagent, PPHF, Poly(pyridine fluoride), Pyridine hydrofluoride, Pyridinium poly(hydrogen fluoride), Pyridinium polybifluoride
HF-吡啶 Olah's reagent PPHF Poly(pyridine fluoride) Pyridinium poly(hydrogen fluoride) Pyridinium polybifluoride 氟化氢吡啶
HYDROGEN FLUORIDE PYRIDINE COMPLEX
HYDROGEN FLUORIDE PYRIDINE, 70% AS HYDROGEN FLUORIDE, 30% AS PYRIDINE
Hydrofluoric acid, homopolymer, compd. with
Hydrogen fluoride, pyridine reagent, anhydrous
Hydrogen fluoride-pyridine
Olah's Reagent
Olah's reagent
PYRIDINE HYDROFLUORIDE
PYRIDINIUM POLY(HYDROGEN FLUORIDE)
PYRIDINIUM POLY(HYDROGEN FLUORIDE) COMPLEX(APPROX 20% HF:80% PYRIDINE W/W)
Poly(pyridine fluoride)
{} {} {} {} {} {} {Chem
吡啶氢氟酸盐
氟化氢吡啶;Olanh试剂;PPHF |
| Merck Number | 14,6821 |
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| Beilstein Registry Number | 4750151 |
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| PubChem Substance ID | 24851101 |
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| Chemical Name Translation | 氟化氢吡啶络合物 |
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| EC Number | 250-889-6 |
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| Warnings |
MOISTURE SENSITIVE, KEEP COLD, TOXIC, CORROSIVE |
| Safety Statements | |
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- S20 When using do not eat or drink 使用时，不得进食，饮水；
- S23 Do not breathe gas/fumes/vapour/spray (appropriate wording to be specified by the manufacturer) 不要吸入气体/烟雾/蒸汽/喷雾；
- S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
- S27/28
- S28 After contact with skin, wash immediately with plenty of ... (to be specified by the manufacturer) 皮肤接触后，立即用大量…（由生产厂家指定）冲洗；
- S35 This material and its container must be disposed of in a safe way 该物料及其容器必须以安全方式处置；
- S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
- S4 Keep away from living quarters 远离生活区；
- S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
- S60 This material and its container must be disposed of as hazardous waste 该物质及其容器必须作为危险废物处置；
- S61 Avoid release to the environment. Refer to special instructions/safety data sheet 避免释放到环境中，参考特别指示/安全收据说明书；
- S9 Keep container in a well-ventilated place 保持容器在通风良好的场所；
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| Packing Group | I |
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| UN Number |
1790
UN 1790 8/PG 1
UN1790
UN2922 |
| Risk Statements | |
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- R26/27/28 Very toxic by inhalation, in contact with skin and if swallowed 吸入，皮肤接触及吞食都有剧毒
- R35 Causes severe burns 会导致严重灼伤
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| Storage condition |
Moisture Sensitive
储存温度-20°C
Keep Cold/Store in Nalgene |
| WGK Germany | 2 |
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| Precautionary statements | |
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- P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
- P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
- P284 Wear respiratory protection.? 佩戴呼吸保护装置。
- P301+P310
- P302+P350
- P303+P361+P353
- P304+P340+P310
- P305+P351+P338
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| Signal word |
Danger |
| Hazard statements | |
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- H314 Causes severe skin burns and eye damage 导致严重的皮肤灼伤和眼睛损伤
- H300+H310+H330
- H330 Fatal if inhaled 吸入致命
- H310 Fatal in contact with skin 皮肤接触致命
- H300 Fatal if swallowed 吞食致命
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GHS Symbol
| Personal Protective Equipment |
Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
| Hazard Codes |
8
T
T+,C
T+,T,C |
Convenient form of anhydrous HF, stable up to 50°C. Has been used for the preparation of β-fluoroamines from amino alcohols and for the fluorination of acetylenes.
Used together with hypervalent iodine(III) reagents for ipso-fluorination of para-substituted phenols providing cyclohexadienones. Employed for geminal fluorination of 2,2-diaryl-1,3-dithiolane?s.
Reactant for preparation of:
Epimers of shikimic acid with the features of fucosylated glycans via zinc-mediated reductive ring opening followed by a Barbier reaction
Vaccinia H1-related (VHR) phosphatase inhibitor with a nonacidic phosphate-mimicking core structure
Candidates for nucleic acid drugs
ω-substituted gem-difluoroalkanes by oxidative desulfurization-difluorin?ation
Reagent for:
Halofluorination reactions
{ALF} The reagent is also widely applied to the cleavage of a variety of silyl protecting groups including TBDMS, TES, TBDPS and TIPS: Synthesis, 453 (1986); J. Am .Chem. Soc., 112, 7001 (1990); for further discussion see: P. Kocienski, Protecting Groups, Thieme, Stuttgart (1994).
{uni_hamburg} Short: EINECS
{ALF} Convenient form of anhydrous HF, showing increased reactivity in many reactions: J. Org. Chem., 44, 3872 (1979). Alkenes and alkynes undergo hydrofluorination; in the presence of NIS or NBS, iodo- or bromofluorination occurs: Synthesis, 779 (1973). Secondary and tertiary alcohols are converted to alkyl fluorides: Synthesis, 653 (1974). Diazotization of ɑ-amino acids in the presence of the reagent provides good yields of ɑ-fluoro acids: Synthesis, 654 (1974). Reaction with aryldiazonium salts or triazenes leads to aryl fluorides, providing a convenient alternative to the Balz-Schiemann reaction (see Tetrafluoroboric acid, L14037): J. Am. Chem. Soc., 97, 208 (1975); J. Chem. Soc., Chem. Commun., 914 (1979); Bull. Chem. Soc. Jpn., 63, 2058 (1990).
{ALF} In combination with nitrosonium tetrafluorborate, ketoximes are converted to gem-difluorides: Synlett, 425 (1994).
{ALF} For use in electrophilic electrochemical fluorination, see: J. Fluorine Chem., 83, 31 (1997).
{ALF} In combination with nitrosonium tetr
{uni_hamburg} Short: II/2
