Sodium ethoxide 乙醇钠

规格: 20% solution in ethanol, SpcSeal
CAS: 141-52-6
产品编号: H28569
MDL: MFCD00012417
品牌: INFI
Chemical NameSodium Ethoxide
EC Number205-487-5
Beilstein Registry Number3593646
Synonym Caustic alcohol;Sodium ethoxide NE-21 SODIUM ETHYLATE Sodiumethoxideinethanol ethoxysodium ethylalcohol,sodiumsalt sodiumethylate(sodiumethoxide) 乙氧基钠 乙氧基钠,乙醇钠盐,乙氧钠 乙氧基钠;乙氧钠 乙氧钠 乙醇钠
PubChem Substance ID87559550
Merck Number8539
Reaxys-RN3593646
Chemical Name Translation乙醇钠
LabNetwork Molecule IDLN00164557
InChIInChI=1S/C2H5O.Na/c1-2-3;/h2H2,1H3;/q-1;+1
MDL NumberMFCD00012417
CAS Number141-52-6
GHS Symbol
Signal word Danger
WGK Germany1
Safety Statements
  • S16 Keep away from sources of ignition - No smoking 远离火源，禁止吸烟；
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
  • S43 In case of fire use ... (indicate in the space the precise type of fire-fighting equipment. If water increases the risk add -?Never use water) 着火时使用（指明具体的消防器材种类，如果用水增加危险，注明“禁止用水”
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
  • S8 Keep container dry 保持容器干燥；
    Risk Statements
    • R11 Highly flammable 非常易燃
    • R14 Reacts violently with water 遇水会猛烈反应
    • R34 Causes burns 会导致灼伤
    • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
      Precautionary statements
      • P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking. 远离热源/火花/明火/热的表面。——禁止吸烟。
      • P235+P410
      • P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
      • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
      • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
      • P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
      • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
      • P301+P330+P331+P310
      • P303+P361+P353+P310+P363
      • P304+P340
      • P304+P340+P310
      • P305+P351+P338
      • P305+P351+P338+P310
      • P308+P313
      • P310 Immediately call a POISON CENTER or doctor/physician. 立即呼救解毒中心或医生/医师。
      • P403+P233
      • P405 Store locked up. 上锁保管。
      • P407 Maintain air gap between stacks/pallets. 在堆叠/货板间保持气隙。
      • P420 Store away from other materials. 远离其他材料。
      • P501 Dispose of contents/container to..… 处理内容物/容器.....
        Hazard statements
        • H225 Highly flammable liquid and vapour 高度易燃液体和蒸气
        • H251 Self-heating: may catch fire 自我放热：可能着火
        • H252 Self-heating in large quantities; may catch fire 自我释放大量的热；可能着火。
        • H314 Causes severe skin burns and eye damage 导致严重的皮肤灼伤和眼睛损伤
          Personal Protective Equipment Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
          Packing GroupII
          UN Number 3206
          Storage condition Moisture Sensitive Store at R.T. Air & Moisture Sensitive 充氩保存 密封阴凉干燥避光保存。
          Hazard Codes 4.2 F,C
          Hazard Class4.2/8
          Warnings 危化品目录(2015)
          Restrict 危险品
        • 用作强碱性催化剂；乙氧基化剂以及作为一种凝聚剂和还原剂用于有机合成中。应用乙醇钠的医药产品有苯比妥；保泰松；扑痫酮；甲基多巴；丁卡因盐酸盐；易咳嗪；氨蝶呤；乙胺嘧啶；匹呋氨苄青霉素等。此外，还用于农药及作分析试剂。
        • {ALF} Extensively used as a base for the generation of carbanions in a variety of alkylation and condensation reactions. Organic Syntheses examples of the use of solid sodium ethoxide include:
        • {ALF} Condensation of acetone with ethyl acetate: Org. Synth. Coll., 3, 17 (1955). Benzoylation of acetophenone with ethyl benzoate: Org. Synth. Coll., 3, 251 (1955). ɑ-Formylations with ethyl formate: Org. Synth. Coll., 3, 300 (1955); 4, 536 (1963). ɑ-Ethoxalylation of diethyl succinate with diethyl oxalate: Org. Synth. Coll., 5, 687 (1973).
        • {ALF} In reactions where the presence of excess ethanol is undesirable, the use of pre-formed solid sodium ethoxide is much more convenient and safer than preparation in situ from sodium metal. This applies to many literature condensation reactions which employ powdered sodium in, for example ether or toluene, where the difficulty and hazards of obtaining a satisfactory sodium dispersion can be considerable. Solid sodium ethoxide often gives superior results, with better control of exothermic reactions.
        • {ALD} Merck: 14,8613
        • {ALD} Merck: 14,8613
        • Beilstein: 1,IV,1289
          • 141-52-6 H28569 Sodium ethoxide 乙醇钠

          化学属性

          Density0.868
          Refractive index1.3850
          Vapor Density1.6 (vs air)
          Vapor Pressure<;0.1 mmHg ( 20 °C)
          Flash Point30°C(lit.)
          TSCAYes
          Melting Point>300
          Boiling Point91 ºC
          SolubilityMISCIBLE
          Mol. FormulaC2H5ONa
          Mol. Weight68
          Appearance white to yellow pwdr.
          Stabilitymoisture sensitive

          *以上化合物性质及应用等信息仅供参考