2,2,2-Trifluoroethanol 2,2,2-三氟乙醇

规格: 99%
CAS: 75-89-8
产品编号: H37853
MDL: MFCD00004672
品牌: INFI
Chemical Name2,2,2-Trifluoroethanol
Synonym 1,1,1-trifluoroethanol 2,2,2-Trifluoroethanol Alcohol, Trifluoroethyl Ethanol,2,2,2-trifluoro- TRIFLUOROETHANOL Trifluoroethanol Trifluoroethyl Alcohol Trifluoroethyl alcohol
EC Number200-913-6
Beilstein Registry Number1733203
PubChem Substance ID6409
Reaxys-RN1733203
Merck Number9682
Chemical Name Translation2,2,2-三氟乙醇
Wiswesser Line NotationQ1XFFF
LabNetwork Molecule IDLN00193055
InChIInChI=1S/C2H3F3O/c3-2(4,5)1-6/h6H,1H2
MDL NumberMFCD00004672
CAS Number75-89-8
GHS Symbol
TYPE OF TEST            : LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 2900 mg/m3/2H
TOXIC EFFECTS :
   Brain and Coverings - changes in circulation (hemorrhage, thrombosis, etc.)
   Behavioral - general anesthetic
   Lungs, Thorax, or Respiration - structural or functional change in trachea
   or bronchi
REFERENCE :
   GTPZAB Gigiena Truda i Professional'nye Zabolevaniya.  Labor Hygiene and
   Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
   V.1-36, 1957-1992. For publisher information, see MTPEEI
   Volume(issue)/page/year: 13(10),29,1969

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 158 mg/kg
TOXIC EFFECTS :
   Behavioral - changes in motor activity (specific assay)
REFERENCE :
   AMEBA7 Annales Medicinae Experimentalis et Biologiae Fenniae.  (Helsinki,
   Finland)  V.25-51, 1947-73. For publisher information, see MDBYAS.
   Volume(issue)/p

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 210 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 240 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   34ZIAG "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York,
   Academic Press, Inc., 1969  Volume(issue)/page/year: -,607,1969

TYPE OF TEST            : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 100 ppm/6H
SEX/DURATION            : male 14 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Paternal Effects - testes, epididymis, sperm duct
   Reproductive - Fertility - male fertility index (e.g. # males impregnating
   females per # males exposed to fertile nonpregnant females)
REFERENCE :
   TOXID9 Toxicologist.  (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway,
   Akron, OH 44311) V.1-    1981-  Volume(issue)/page/year: 1,27,1981

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 200 mg/kg
SEX/DURATION            : male 4 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Paternal Effects - spermatogenesis (incl. genetic material,
   sperm morphology, motility, and count)
   Reproductive - Paternal Effects - testes, epididymis, sperm duct
   Reproductive - Paternal Effects - other effects on male
REFERENCE :
   TOXID9 Toxicologist.  (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway,
   Akron, OH 44311) V.1-    1981-  Volume(issue)/page/year: 4,137,1984

TYPE OF TEST            : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Mammal - dog
DOSE                    : 400 mg/m3/6H
SEX/DURATION            : male 8 week(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Paternal Effects - spermatogenesis (incl. genetic material,
   sperm morphology, motility, and count)
   Reproductive - Paternal Effects - testes, epididymis, sperm duct
REFERENCE :
   TOLED5 Toxicology Letters.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1977-  Volume(issue)/page/year: 18(Suppl
   1),138,1983

Signal word Danger
WGK Germany1
Safety Statements
  • S23 Do not breathe gas/fumes/vapour/spray (appropriate wording to be specified by the manufacturer) 不要吸入气体/烟雾/蒸汽/喷雾;
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后,立即用大量水冲洗并征求医生意见;
  • S36 Wear suitable protective clothing 穿戴适当的防护服;
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护;
  • S39 Wear eye/face protection 戴眼睛/面孔保护装置;
  • S60 This material and its container must be disposed of as hazardous waste 该物质及其容器必须作为危险废物处置;
  • S9 Keep container in a well-ventilated place 保持容器在通风良好的场所;
    Risk Statements
    • R10 Flammable 易燃
    • R20/21/22 Harmful by inhalation, in contact with skin and if swallowed 吸入、皮肤接触和不慎吞咽有害
    • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
    • R37/38 Irritating to respiratory system and skin 对呼吸系统和皮肤有刺激性
    • R38 Irritating to skin 刺激皮肤
    • R41 Risk of serious damage to eyes 有严重损伤眼睛的危险
    • R62 Possible risk of impaired fertility 有削弱生殖能力的危险
      Precautionary statements
      • P201 Obtain special instructions before use. 使用前获取专门指示。
      • P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前,切勿操作。
      • P203
      • P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking. 远离热源/火花/明火/热的表面。——禁止吸烟。
      • P233 Keep container tightly closed. ?保持容器密闭。
      • P240 Ground/bond container and receiving equipment. 与地面接触/连接集装箱和接受设备。
      • P241 Use explosion-proof electrical/ventilating/lighting/…/equipment. 使用防爆电气/通风/照明/ .../设备。
      • P241+P242+P243
      • P242 Use only non-sparking tools. 只能使用无火花工具。
      • P243 Take precautionary measures against static discharge. 采取预防措施,防止静电放电。
      • P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
      • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
      • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
      • P264+P265
      • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西,喝水或吸烟。
      • P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
      • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
      • P281 Use personal protective equipment as required. 使用所需的个人防护装备。
      • P301+P310
      • P301+P310+P330
      • P301+P316
      • P302+P352
      • P302+P352+P312+P361+P364
      • P303+P361+P353
      • P304+P312
      • P304+P340
      • P304+P340+P311
      • P305+P351+P338
      • P305+P351+P338+P310
      • P305+P354+P338
      • P308+P313
      • P310 Immediately call a POISON CENTER or doctor/physician. 立即呼救解毒中心或医生/医师。
      • P311 Call a POISON CENTER or doctor/physician. 呼叫解毒中心或医生/医师。
      • P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适,呼叫解毒中心或医生/医师。
      • P314 Get medical advice/attention if you feel unwell. 获取医疗咨询/就医,如果你觉得不舒服
      • P316
      • P317
      • P318
      • P319
      • P321 Specific treatment (see … on this label). 具体治疗(见本标签上的)。
      • P322 Specific measures (see …on this label). 具体治疗(见本标签上的)。
      • P330 Rinse mouth. 漱口
      • P332+P313
      • P332+P317
      • P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服,清洗后方可重新使用
      • P362+P364
      • P363 Wash contaminated clothing before reuse. 被污染的衣服洗净后方可重新使用。
      • P370+P378
      • P403+P233
      • P403+P235
      • P405 Store locked up. 上锁保管。
      • P501 Dispose of contents/container to..… 处理内容物/容器.....
        Hazard statements
        • H226 Flammable liquid and vapour 易燃液体和蒸气
        • H301 Toxic if swallowed 吞食有毒
        • H301+H331
        • H312 Harmful in contact with skin 皮肤接触有害
        • H315 Causes skin irritation 会刺激皮肤
        • H318 Causes serious eye damage 严重伤害眼睛
        • H331 Toxic if inhaled 吸入中毒
        • H332 Harmful if inhaled 吸入有害
        • H335 May cause respiratory irritation 可能导致呼吸道刺激
        • H360 May damage fertility or the unborn child 可能对生育能力或未出生婴儿造成伤害
        • H373 May causes damage to organs through prolonged or repeated exposure 长期或频繁接触可能会损伤器官
          Personal Protective Equipment Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
          RTECSKM5250000
          Packing GroupIII
          UN Number 1986 UN 1986 3/PG 3
          Hazard Codes 3
          Hazard Class3/6.1
          Storage condition 充氩储存 Store at RT.
          Warnings 危化品目录(2015)
          Restrict 危险品
        • 重要溶剂,用于在电泳中样品制备的重要溶剂。也用于核磁光谱
        • {ALD} Merck: 14,9682
        • {ALF} Effective solvent for uncatalyzed epoxidations of alkenes with hydrogen peroxide (caution! 60%): Synlett, 248 (2001). For a review of fluorinated alcohols as solvents for selective and clean reactions, see: Synlett, 18 (2004).
        • {ALD} Merck: 14,9682
        • Beilstein:1(4)1370
        • {ALF} Trifluoroethyl esters have also found use as active esters in peptide coupling; see, for example: J. Chem. Soc., Perkin 1, 2867 (1996).
        • {ALF} The stereodirecting effect of the MEM group (see 2-Methoxyethoxymethyl­ chloride, L01050) has been exploited by Percy et al in the formation of a new fluorine-containing acyl anion equivalent: Tetrahedron, 51, 9201 (1995):
        • {uni_hamburg} Short: II/25B
        • {ALF} Reacts with triphenylphosphine dibromide to give the bis(trifluoroethoxy)phosphorane, which converts alcohols to trifluoroethyl ethers, carboxylic acids to trifluoroethyl esters and aldehydes to bis(trifluoroethyl) acetals: J. Org. Chem., 45, 5052 (1980).
        • {ALF} Useful ionizing solvent, see: Tetrahedron Lett., 2335 (1974), and references therein. Good solvent for oligopeptides with potential as a cosolvent along with proton acceptors such as DMF for peptide coupling reactions: Tetrahedron Lett., 33, 7007 (1992). Compare 1,1,1,3,3,3-Hexafluoro-2-propanol, A12747.
        • {ALF} Claisen or Wittig rearrangements of the derived difluoroallyl alcohols can be used in routes to molecules containing a CF2 group: Tetrahedron, 51, 11327 (1995); J. Org. Chem., 61, 166 (1996), or to monofluorinated vinylic compounds: Tetrahedron Lett., 37, 5183 (1996).
        • {uni_hamburg} Short: II/24B
        • 75-89-8 H37853 2,2,2-Trifluoroethanol
2,2,2-三氟乙醇

          化学属性

          Autoignition Point~896 °F
          Refractive indexn20/D 1.3(lit.)
          Vapor Density3.5 (vs air)
          Vapor Pressure70 mmHg ( 25 °C)
          TSCAYes
          Solubility和水混溶,和乙醇、酮、酯和醚混溶。
          Stability对湿度敏感
          Mol. FormulaC2H3F3O
          Mol. Weight100
          Density1.373
          Flash Point85°F
          Appearance colorless liq.
          Boiling Point77-80
          Melting Point-44

          *以上化合物性质及应用等信息仅供参考