Imidazole 咪唑

规格: 99%
CAS: 288-32-4
产品编号: H39571
MDL: MFCD00005183
品牌: INFI
Chemical NameImidazole
CAS Number288-32-4
Synonym Imidazole {LY} Imidazole {} {LY} Imidazole {} {} {LY} Imidazole {} {} {} {LY} Imidazole {} {} {} {} {LY} Imidazole {} {} {} {} {} {LY} Imidazole {} {} {} {} {} {} {LY} Imidazole {} {} {} {} {} {} {} {LY} Imidazole {} {} {} {} {} {} {} {} {LY} Imidazole {} {} {} {} {} {} {} {} {} {LY} Imidazole {} {} {} {} {} {} {} {} {} {} {LY} Imidazole {} {} {} {} {} {} {} {} {} {} {} {LY} Imidazole {} {} {} {} {} {} {} {} {} {} {} {} {LY} Imidazole {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Imidazole {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Imidazole {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Imidazole {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Imidazole {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Imidazole {} {} {} {} {} {} {} {} {} {} {} {} {} {
PubChem Substance ID87571424
Beilstein Registry Number103853
MDL NumberMFCD00005183
Reaxys-RN103853
Merck Number4912
EC Number206-019-2
Chemical Name Translation咪唑
Wiswesser Line NotationT5M CNJ
LabNetwork Molecule IDLN00194310
InChIInChI=1S/C3H4N2/c1-2-5-3-4-1/h1-3H,(H,4,5)
Canonical SMILESC1=NC=CN1
GHS Symbol
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 220 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   PREPAB Przeglad Epidemiologiczny.  (Panstwowy Zaklad Wydawnictw Lekarskich,
   ul. Dluga 38-40, 00-238 Warsaw, Poland)  V.1-    1947-
   Volume(issue)/page/year: 67,295

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 28 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   PREPAB Przeglad Epidemiologiczny.  (Panstwowy Zaklad Wydawnictw Lekarskich,
   ul. Dluga 38-40, 00-238 Warsaw, Poland)  V.1-    1947-
   Volume(issue)/page/year: 67,295,1993

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 817 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 119,444,1957

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 475 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 33,716,1983

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral

TYPE OF TEST            : DNA inhibition
TEST SYSTEM             : Human Cells - not otherwise specified
DOSE/DURATION           : 1 mmol/L
REFERENCE :
   JIDEAE Journal of Investigative Dermatology.  (Williams & Wilkins Co., 428
   E. Preston St., Baltimore, MD 21202)  V.1-    1938- Volume(issue)/page/year:
   65,400,1975

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 150 mg/kg
SEX/DURATION            : male 1 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Paternal Effects - impotence
REFERENCE :
   NLETDU Neuroendocrinology Letters.  (Brain Research Promotion, D-7400,
   Tubingen, Germany) V.1-    1979-  Volume(issue)/page/year: 12,69,1990

WGK Germany1
Hazard Codes 8 C,Xi T
Hazard statements
  • H301 Toxic if swallowed 吞食有毒
  • H314 Causes severe skin burns and eye damage 导致严重的皮肤灼伤和眼睛损伤
  • H360 May damage fertility or the unborn child 可能对生育能力或未出生婴儿造成伤害
  • H302 Harmful if swallowed 吞食有害
    Personal Protective Equipment Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
    Precautionary statements
    • P201 Obtain special instructions before use. 使用前获取专门指示。
    • P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前，切勿操作。
    • P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
    • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
    • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
    • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
    • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
    • P301+P330+P331+P310
    • P303+P361+P353
    • P303+P361+P353+P310+P363
    • P304+P340
    • P304+P340+P310
    • P305+P351+P338
    • P305+P351+P338+P310
    • P308+P311
    • P308+P313
    • P310 Immediately call a POISON CENTER or doctor/physician. 立即呼救解毒中心或医生/医师。
    • P405 Store locked up. 上锁保管。
    • P501 Dispose of contents/container to..… 处理内容物/容器.....
      Signal word Danger
      RTECSNI3325000
      UN Number 1759 2923 3263
      Storage condition 2-8°C {LY} 2-8°C {} {LY} 2-8°C {} {} {LY} 2-8°C {} {} {} {LY} 2-8°C {} {} {} {} {LY} 2-8°C {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {
      Safety Statements
      • S22 Do not breathe dust 不要吸入粉尘；
      • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
      • S36 Wear suitable protective clothing 穿戴适当的防护服；
      • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
      • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
      • S53 Avoid exposure - obtain special instructions before use 避免接触，使用前获得特别指示说明；
      • S60 This material and its container must be disposed of as hazardous waste 该物质及其容器必须作为危险废物处置；
        Risk Statements
        • R22 Harmful if swallowed 吞咽有害
        • R34 Causes burns 会导致灼伤
        • R36/38 Irritating to eyes and skin 对眼睛和皮肤有刺激性
        • R61 May cause harm to the unborn child 可能对未出生的婴儿导致伤害
        • R63 Possible risk of harm to the unborn child 可能危害未出生婴儿
          Packing GroupIII
          Hazard Class8/6.1
        • 钴的测定。有机合成。用于抗新陈代谢、抗组织胺。pH值在6.2-7.8范围内，可作为缓冲液。天门冬氨酸和谷氨酸滴定
        • {TRC} Arispe, N. et al.: Biophys. J., 95, 4879 (2008); Troesken, E.R. et al.: Endo. Res., 30, 387 (2004); Otmacic Curkovic, H. et al.: Corr. Sci., 51, 2342 (2009);
        • {ALF} For use in: silylation of 1,3-diketones, see Hexamethyl­disilazane, A15139; introduction of the TBDMS and TBDPS groups; see: tert-Butyl­dimethyl­chlorosilane, A13064, and tert-Butyl­diphenyl­chlorosilane, A12721, respectively.
        • {ALF} In combination with triphenylphosphine and iodine, vic-diols are converted to alkenes: Synthesis, 469 (1979), and alcohols to alkyl iodides: Synth. Commun., 20, 1473 (1990).
        • {ALD} Merck: 14,4912
        • {ALD} Merck: 14,4912
        • Beilstein: 23,V,4,191
        • {ALF} Nucleophilic catalyst for many acylation and silylation reactions, compare 4-(Dimethyl­amino)­pyridine, A13016.
        • {uni_hamburg} Short: II/14a
        • {uni_hamburg} Short: II/19b
        • {ALF} With 2 moles of an aroyl halide gives, after hydrolysis, good yields of 2-aroylimidazoles: Synthesis, 675 (1978).
          • 288-32-4 H39571 Imidazole 咪唑

          化学属性

          Mol. FormulaC3H4N2
          Mol. Weight68.08
          Density1.03
          Flash Point145°(293°F)
          TSCAYes
          Melting Point88-91°C
          Boiling Point257°C at 760 mmHg
          Vapor Pressure<;1 mmHg ( 20 °C)
          Solubility633 G/L (20 ºC)
          Appearance crystalline 无色棱形结晶。熔点90-91℃，沸点257℃，165-168℃（2.67kPa），138.2℃（1.6kPa），闪点145℃。易溶于水，醇、醚、氯仿和吡啶，微溶于苯，极微溶于石油醚。呈弱碱性。
          Refractive index1.4801
          Stability对热和空气敏感

          *以上化合物性质及应用等信息仅供参考