Maleic anhydride 顺丁烯二酸酐

规格: 98%
CAS: 108-31-6
产品编号: H70638
MDL: MFCD00005518
品牌: INFI
Chemical NameMaleic Anhydride
CAS Number108-31-6
Synonym Furan-2,5-dione {LY} Furan-2,5-dione {} {LY} Furan-2,5-dione {} {} {LY} Furan-2,5-dione {} {} {} {LY} Furan-2,5-dione {} {} {} {} {LY} Furan-2,5-dione {} {} {} {} {} {LY} Furan-2,5-dione {} {} {} {} {} {} {LY} Furan-2,5-dione {} {} {} {} {} {} {} {LY} Furan-2,5-dione {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {LY} Furan-2,5-dione {} {} {} {} {} {} {} {} {} {LY} Furan-2,5-dione {} {} {} {} {} {} {} {} {} {} {LY} Furan-2,5-dione {} {} {} {} {} {} {} {} {} {} {} {LY} Furan-2,5-dione {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Furan-2,5-dione {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Furan-2,5-dione {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Furan-2,5-dione {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Furan-2,5-dione {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Furan-2,5-dione
MDL NumberMFCD00005518
Beilstein Registry Number106909
PubChem Substance ID7923
EC Number203-571-6
Merck Number5704
Reaxys-RN106909
Chemical Name Translation马来酸酐
Wiswesser Line NotationT5VOVJ
LabNetwork Molecule IDLN00193030
InChIInChI=1S/C4H2O3/c5-3-1-2-4(6)7-3/h1-2H
Canonical SMILESO=C1C=CC(O1)=O
GHS Symbol
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1220 mg/kg/61W-I
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Tumorigenic - tumors at site of application
REFERENCE :
   BJCAAI British Journal of Cancer.  (Macmillan Press Ltd., Houndmills,
   Basingstoke, Hants. RG21 2XS, UK)  V.1-    1947-  Volume(issue)/page/year:
   17,100,1963

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - guinea pig
DOSE/DURATION           : 390 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single
   Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects,
   GKNT, 1982  Volume(issue)/page/year: -,79,1982

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - guinea pig
DOSE/DURATION           : >20 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   IAEC** Interagency Collaborative Group on Environmental Carcinogenesis,
   National Cancer Institute, Memorandum, June 17, 1974
   Volume(issue)/page/year: 17JUN1974

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 2620 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   42,417,1977

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 465 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   GTPZAB Gigiena Truda i Professional'nye Zabolevaniya.  Labor Hygiene and
   Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
   V.1-36, 1957-1992. For publisher information, see MTPEEI
   Volume(issue)/page/year

TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Rodent - hamster Lung
DOSE/DURATION           : 230 mg/L
REFERENCE :
   GMCRDC Gann Monograph on Cancer Research.  (Plenum Pub. Corp., 233 Spring
   St., New York, NY 10013) No. 11-    1971-  Volume(issue)/page/year:
   27,95,1981

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 4060 mg/kg
SEX/DURATION            : multigenerations
TOXIC EFFECTS :
   Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight
   gain)
REFERENCE :
   FAATDF Fundamental and Applied Toxicology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1981-  Volume(issue)/page/year:
   7,359,1986

WGK Germany1
Hazard statements
  • H302 Harmful if swallowed 吞食有害
  • H314 Causes severe skin burns and eye damage 导致严重的皮肤灼伤和眼睛损伤
  • H317 May cause an allergic skin reaction 可能导致皮肤过敏
  • H334 May cause allergy or asthma symptoms or breathing difficulties if inhaled 吸入可能导致过敏或哮喘症状或呼吸困难
  • H372 Causes damage to organs through prolonged or repeated exposure 长期或频繁接触会损伤器官
  • H373 May causes damage to organs through prolonged or repeated exposure 长期或频繁接触可能会损伤器官
    Personal Protective Equipment Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
    RTECSON3675000
    Precautionary statements
    • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
    • P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
    • P303+P361+P353
    • P284 Wear respiratory protection.? 佩戴呼吸保护装置。
    • P304+P340+P310
    • P305+P351+P338
    • P301+P330+P331+P310
    • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
    • P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
    • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
    • P501 Dispose of contents/container to..… 处理内容物/容器.....
    • P342+P311
    • P403+P233
    • P305+P351+P338+P310
      Signal word
      Hazard Codes C
      Safety Statements
      • S22 Do not breathe dust 不要吸入粉尘；
      • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
      • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
      • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
        Risk Statements
        • R42/43
        • R22 Harmful if swallowed 吞咽有害
        • R34 Causes burns 会导致灼伤
        • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
          UN Number
          Packing GroupIII
          Storage condition Store at room temperature {LY} Store at room temperature {} {LY} Store at room temperature {} {} {LY} Store at room temperature {} {} {} {LY} Store at room temperature {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {}
          Hazard Class8
          Warnings 危化品目录(2015)
          Restrict 危险品
        • Maleic Anhydride is heterocyclic compound used in the manufacture of unsaturated polyester resins. Maleic Anhydride has a wide range of other applications; it is used in synthetic tensides, insecticid
        • {uni_hamburg} Short: II/19b
        • {ALF} Reactive dienophile. For a review of its Diels-Alder reactions, see: Org. React., 4, 1 (1948). For examples, see: Org. Synth. Coll., 3, 807 (1955); 4, 890 (1963). For reaction with Danishefsky's diene (1-Methoxy-3-trimethyl­siloxy-1,3-butadiene, L14672), see: Org. Synth. Coll., 7, 312 (1990).
        • {ALF} For use in combination with Urea hydrogen peroxide adduct, L13940, to generate peroxymaleic acid in epoxidation and Baeyer-Villiger reactions, see: Heterocycles, 36, 1075 (1993). Peroxymaleic acid can also be generated in situ from maleic anhydride and 30% H2O2 in NMP, and has been found to be a very effective oxidant for conversion of sulfides to sulfoxides. For a study of stoichiometric and catalytic oxidations with this system, see: J. Org. Chem., 61, 5693 (1996).
        • {uni_hamburg} Short: II/14a
        • {ALF} For thermal (2+2)-cycloaddition with allene at high temperature, see: Org. Synth. Coll., 5, 459 (1973).
        • {ALD} Merck:14,5704
        • {ALD} Merck:14,5704
        • Beilstein:17,432
        • {ALF} Also undergoes photochemical and thermal (2+2)-cycloadditions with alkenes. For reaction with 1-alkynes, see: Chem. Ber., 102, 3974 (1969).
        • {TRC} Hanafi, W.Z.A. et al.: Plast. Rub. Comp. Proc. Appl., 19, 175 (1993); Noma, K. et al.: Shik. Kyok., 36, 225 (1963); Augustin, M. et al.: Wissen. Zeitsch., 25, 5 (1976); Jiang, Q. et al.: Nongyao, 49,
          • 108-31-6 H70638 Maleic anhydride 顺丁烯二酸酐

          化学属性

          Mol. FormulaC4H2O3
          Mol. Weight98.06
          Autoignition Point870 °F
          Vapor Density3.4 (vs air)
          Boiling Point-
          Vapor Pressure0.16 mmHg ( 20 °C)
          Melting Point52 - 55°C
          Flash Point103.33°C
          Density1.48
          Solubility溶于水、丙酮、苯、氯仿等多数有机溶剂。
          TSCAYes
          Stability对湿度敏感
          Appearance powder

          *以上化合物性质及应用等信息仅供参考