Tetrahydrofuran 四氢呋喃

规格: 99.5%, SpcDry, Water≤50 ppm (by K.F.), SpcSeal
CAS: 109-99-9
产品编号: H17996
MDL: MFCD00005356
品牌: INFI
Chemical NameTetrahydrofuran
Synonym Diethylene oxide, 1,4-Epoxybutane, Cyclotetramethylene oxide
CAS Number109-99-9
PubChem Substance ID8028
EC Number203-726-8
Beilstein Registry Number102391
MDL NumberMFCD00005356
Reaxys-RN102391
Merck Number9211
Chemical Name Translation四氢呋喃
InChIKeyWYURNTSHIVDZCO-UHFFFAOYSA-N
Wiswesser Line NotationT5OTJ
LabNetwork Molecule IDLN00163254
InChIInChI=1S/C4H8O/c1-2-4-5-3-1/h1-4H2
GHS Symbol
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - guinea pig
DOSE/DURATION           : 2300 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   GISAAA Gigiena i Sanitariya.  For English translation, see HYSAAV.  (V/O
   Mezhdunarodnaya Kniga, 113095 Moscow, USSR)  V.1-    1936-
   Volume(issue)/page/year: 34(9),114,1969

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - guinea pig
DOSE/DURATION           : 500 mg/kg
TOXIC EFFECTS :
   Liver - fatty liver degeneration
REFERENCE :
   AIHAAP American Industrial Hygiene Association Journal.  (AIHA, 475 Wolf
   Ledges Pkwy., Akron, OH 44311)  V.19-    1958-  Volume(issue)/page/year:
   35,21,1974

TYPE OF TEST            : LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 21000 ppm/3H
TOXIC EFFECTS :
   Behavioral - sleep
   Lungs, Thorax, or Respiration - respiratory stimulation
   Gastrointestinal - nausea or vomiting
REFERENCE :
   SSEIBV Sumitomo Sangyo Eisei.  Sumitomo Industrial Health.  (Sumitomo Byoin
   Sangyo Eisei Kenkyushitsu, 5-2-2, Nakanoshima, Kita-ku, Osaka 530, Japan)
   No.1-    1965-  Volume(issue)/page/year: 20,141,1984

TYPE OF TEST            : LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 24000 mg/m3/2H
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - muscle weakness
   Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
   TPKVAL Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv.
   Toxicology of New Industrial Chemical Substances.  For English

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 1 umol/L
REFERENCE :
   GTPZAB Gigiena Truda i Professional'nye Zabolevaniya.  Labor Hygiene and
   Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
   V.1-36, 1957-1992. For publisher information, see MTPEEI
   Volume(issue)/page/year: 26(1),43,1982

TYPE OF TEST            : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 1800 ppm/6H
SEX/DURATION            : female 6-17 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
   resorbed implants per total number of implants)
REFERENCE :
   FAATDF Fundamental and Applied Toxicology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1981-  Volume(issue)/page/year:
   18,255,1992

TYPE OF TEST            : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 5000 ppm/6H
SEX/DURATION            : female 6-19 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
REFERENCE :
   FAATDF Fundamental and Applied Toxicology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1981-  Volume(issue)/page/year:
   18,255,1992

WGK Germany1
Hazard Codes 3 F,Xn F;Xi
Hazard statements
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
  • H351 Suspected of causing cancer 怀疑致癌
  • H225 Highly flammable liquid and vapour 高度易燃液体和蒸气
  • H302 Harmful if swallowed 吞食有害
    Personal Protective Equipment Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
    RTECSLU5950000
    Precautionary statements
    • P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking. 远离热源/火花/明火/热的表面。——禁止吸烟。
    • P233 Keep container tightly closed. ?保持容器密闭。
    • P240 Ground/bond container and receiving equipment. 与地面接触/连接集装箱和接受设备。
    • P241+P242+P243
    • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
    • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
    • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西,喝水或吸烟。
    • P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
    • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
    • P301+P312+P330
    • P302+P352+P332+P313+P362+P364
    • P304+P340+P312
    • P305+P351+P338
    • P305+P351+P338+P337+P313
    • P308+P311
    • P332+P313
    • P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服,清洗后方可重新使用
    • P370+P378
    • P403+P233
    • P403+P235
    • P405 Store locked up. 上锁保管。
    • P501 Dispose of contents/container to..… 处理内容物/容器.....
      Signal word Danger
      Safety Statements
      • S13 Keep away from food, drink and animal foodstuffs 远离食品、饮料和动物饲料保存;
      • S16 Keep away from sources of ignition - No smoking 远离火源,禁止吸烟;
      • S23 Do not breathe gas/fumes/vapour/spray (appropriate wording to be specified by the manufacturer) 不要吸入气体/烟雾/蒸汽/喷雾;
      • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后,立即用大量水冲洗并征求医生意见;
      • S29 Do not empty into drains 不要排入下水道;
      • S30 Never add water to this product 切勿将水加入该产品中;
      • S33 Take precautionary measures against static discharges 对静电采取预防措施;
      • S36 Wear suitable protective clothing 穿戴适当的防护服;
      • S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套;
      • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护;
      • S37 Wear suitable gloves 戴适当手套;
      • S43 In case of fire use ... (indicate in the space the precise type of fire-fighting equipment. If water increases the risk add -?Never use water) 着火时使用(指明具体的消防器材种类,如果用水增加危险,注明“禁止用水”
      • S46 If swallowed, seek medical advice immediately and show this container or label 食入时,立即求医并出示容器/标签;
      • S60 This material and its container must be disposed of as hazardous waste 该物质及其容器必须作为危险废物处置;
      • S7/8 Keep container tightly closed and dry 保存在严格密闭容器中,保持干燥;
        Risk Statements
        • R11 Highly flammable 非常易燃
        • R14/15 Reacts violently with water, liberating extremely flammable gases 遇水剧烈反应,释放出高度可燃气体
        • R19 May form explosive peroxides 可能生成易爆的过氧化物质
        • R36/37 Irritating to eyes and respiratory system 对眼睛和呼吸系统有刺激性
        • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
        • R40 Limited evidence of a carcinogenic effect 有限证据表明其致癌作用
          UN Number 2056 UN2056
          Packing GroupII
          Storage condition 密封阴凉处保存。 密封避光阴凉处保存。
          Hazard Class3
          Warnings 危化品目录(2015)
        • 氨基酸和肽的纸层析。溶剂。有机合成。高效液相色谱,紫外发光光度分析。
        • Merck:14,9211
        • Merck:14,9211 Beilstein: 17,V,1,27
        • 109-99-9 H17996 Tetrahydrofuran
四氢呋喃

          化学属性

          Mol. FormulaC4H8O
          Mol. Weight72.11
          Refractive index1.4060 to 1.4090
          Boiling Point65-66
          Density0.889
          Melting Point-108
          Flash Point-15°C(lit.)
          TSCAYes
          Autoignition Point610 °F
          Vapor Density2.5 (vs air)
          Vapor Pressure114 mmHg ( 15 °C)
          Solubility溶于水、乙醇、乙醚、丙酮、苯等多数有机溶剂。
          Stability易吸潮
          Density0.869
          Mol. FormulaC4H8O
          Mol. Weight72.11