L-Glutathione 还原型谷胱甘肽

规格: 98%
CAS: 70-18-8
产品编号: H21967
MDL: MFCD00065939
品牌: INFI
Chemical NameL-γ-Glutamyl-L-cysteinylglycine
Synonym -L-Glutamyl-L-cysteinyl-glycine 5-L-Glutamyl-L-cysteinylglycine 5-L-谷氨酰-L-半胱氨酰甘氨酸 GSH G-L-GLUTAMYL-L-CYSTEINGLYCINE G-L-GLUTAMYL-L-CYSTEINYLGLYCINE GAMMA-GLU-CYS-GLY GLUTAMYLCYSTEINYLGLYCINE, REDUCED GLUTATHIONE, REDUCED GSH;三缩氨基酸;硫糠质;L-还原型谷胱甘肽;还原型谷胱甘肽;还原谷胱甘肽;5-L-谷氨酰-L-半胱氨酰甘氨酸 Glutathion Glutathione Glutathione SH H-GAMMA-GLU-CYS-GLY-OH L-GLUTATHIONE REDUCED L-谷胱甘肽, REDUCED L-谷胱甘肽, reduced, 97% L-还原型谷胱甘肽 Panaron Tathione γ-L-Glutamyl-L-cysteinyl-glycine 三缩氨基酸 谷胱甘胜 还原谷胱甘肽 麩胱甘肽
MDL NumberMFCD00065939
CAS Number70-18-8
Beilstein Registry Number1729812
EC Number200-725-4
Merck Number4475
PubChem Substance ID124886
Chemical Name Translation5-L-谷氨酰-L-半胱氨酰甘氨酸
Reaxys-RN1729812
LabNetwork Molecule IDLN00189025
InChIInChI=1S/C10H17N3O6S/c11-5(10(18)19)1-2-7(14)13-6(4-20)9(17)12-3-8(15)16/h5-6,20H,1-4,11H2,(H,12,17)(H,13,14)(H,15,16)(H,18,19)/t5-,6-/m0/s1
GHS Symbol
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 5 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   85IQAH "Modern Pharmaceuticals of Japan, IV," Tokyo, Japan Pharmaceutical,
   Medical and Dental Supply Exporters' Assoc., 1972  Volume(issue)/page/year:
   -,93,1972

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 5 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   85IQAH "Modern Pharmaceuticals of Japan, IV," Tokyo, Japan Pharmaceutical,
   Medical and Dental Supply Exporters' Assoc., 1972  Volume(issue)/page/year:
   -,93,1972

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 2238 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JJANAX Japanese Journal of Antibiotics.  (Japan Antibiotics Research Assoc.,
   2-20-8 Kamiosaki, Shinagawa-ku, Tokyo 141, Japan)  V.21-    1968-
   Volume(issue)/page/year: 38,137,1985

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intramuscular
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 4 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   85IPAE "Modern Pharmaceuticals of Japan, III," Tokyo, Japan Pharmaceutical,
   Medical and Dental Supply Exporters' Assoc.,  1968 Volume(issue)/page/year:
   -,97,1968

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 35 umol/plate
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    19

TYPE OF TEST            : DNA inhibition
TEST SYSTEM             : Rodent - rat Liver
DOSE/DURATION           : 1 mmol/L
REFERENCE :
   ABBIA4 Archives of Biochemistry and Biophysics.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802)  V.31-    1951-  Volume(issue)/page/year:
   166,400,1975

TY

TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Rodent - hamster Ovary
DOSE/DURATION           : 1 mmol/L
REFERENCE :
   CALEDQ Cancer Letters (Shannon, Ireland).  (Elsevier Scientific Pub. Ireland
   Ltd., POB 85, Limerick, Ireland)  V.1-    1975- Volume(issue)/page/year:
   5,199,1978

TYPE OF TEST            : Unscheduled DNA synthesis
TEST SYSTEM             : Human Fibroblast
DOSE/DURATION           : 1 mmol/L
REFERENCE :
   CALEDQ Cancer Letters (Shannon, Ireland).  (Elsevier Scientific Pub. Ireland
   Ltd., POB 85, Limerick, Ireland)  V.1-    1975- Volume(issue)/page/year:
   5,199,1978

TYPE OF TEST            : Sister chromatid exchange
TEST SYSTEM             : Rodent - hamster Lung
DOSE/DURATION           : 1 mmol/L
REFERENCE :
   CBTOE2 Cell Biology and Toxicology.  (Princeton Scientific Pub., Inc., 301
   N. Harrison St., CN 5279, Princeton, NJ 08540)  V.1-    1984-
   Volume(issue)/page/year: 1(3),123,1985

TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Rodent - hamster Lung
DOSE/DURATION           : 1 mmol/L
REFERENCE :
   CBTOE2 Cell Biology and Toxicology.  (Princeton Scientific Pub., Inc., 301
   N. Harrison St., CN 5279, Princeton, NJ 08540)  V.1-    1984-
   Volume(issue)/page/year: 1(3),123,1985

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 1250 mg/kg
SEX/DURATION            : female 1-22 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
   resorbed implants per total number of implants)
REFERENCE :
   AJANA2 American Journal of Anatomy.  (Alan R. Liss, Inc., 41 E. 11th St.,
   New York, NY 10003) V.1-192, 1901-91.  Volume(issue)/page/year: 110,29,1962

WGK Germany2
RTECSMC0556000
Personal Protective Equipment Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
Safety Statements
  • S24/25 Avoid contact with skin and eyes 避免皮肤和眼睛接触；
    Signal word
    Hazard statements
    • H303 May be harmfully swallowed 吞食可能有害
      Precautionary statements
      • P262 Do not get in eyes, on skin, or on clothing. 不要接触眼睛，皮肤或衣服。
        Storage condition 储存温度2-8°C 2-8°C 储存温度2-8℃,充氩保存
        Risk Statements
        • R68 Possible risk of irreversible effects 可能有不可挽回的作用的危险
        • 做为体内一种重要的抗氧化剂，它能够清除掉人体内的自由基。解毒药，主要用于重金属、丙烯腈、氟化物、一氧化碳及有机溶剂等中毒。
        • 可用5-10 mM从谷胱甘肽琼脂糖中洗脱谷胱甘肽-S-转移酶（GST）。
        • {ALD} Merck: 14,4475
        • {ALD} Merck: 14,4475
        • Beilstein:4(3)1612
        • {MCE} [1]. Pereira-Rodrigues N, et al. Electrocatalytic activity of cobalt phthalocyanine CoPc adsorbed on a graphite electrode for the oxidation of reduced L-glutathione (GSH) and the reduction of its disulfide (GSSG) at physiological pH. Bioelectrochemistry. 2007 Jan;70(1):147-54.
          • 70-18-8

          化学属性

          Mol. FormulaH2NCH(CO2H)CH2CH2CONHCH(CH2SH)CONHCH2CO2H
          Mol. Weight307
          Melting Point192-195
          TSCAYes
          SolubilitySoluble in DMF, ethanol, water (20 mg/ml) at 25 °C, PBS(pH7.2) (~10 mg/ml), diluted alcohol, liquid ammonia, and DMSO.
          Appearance powder
          Refractive index-17 ° (C=2, H2O)
          Density1.441
          Stability对空气敏感

          *以上化合物性质及应用等信息仅供参考