Chlorotrimethylsilane 三甲基氯硅烷

规格: 1.0 M solution in THF, SpcSeal
CAS: 75-77-4
产品编号: H23404
MDL: MFCD00000502
品牌: INFI
Chemical NameChlorotrimethylsilane
Synonym TRIMETHYLSILYL CHLORIDE Trimethylchlorosilane Trimethylchlorosilane, Trimethylsilyl chloride 三甲基氯硅烷 溶液 氯三甲基矽烷
CAS Number75-77-4
EC Number200-900-5
Beilstein Registry Number1209232
MDL NumberMFCD00000502
PubChem Substance ID6397
Reaxys-RN1209232
Chemical Name Translation三甲基氯硅烷
Wiswesser Line NotationG-SI-1&1&1
LabNetwork Molecule IDLN00164280
InChIInChI=1S/C3H9ClSi/c1-5(2,3)4/h1-3H3
GHS Symbol
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1000 mg/kg/I
TOXIC EFFECTS :
   Tumorigenic - neoplastic by RTECS criteria
   Lungs, Thorax, or Respiration - tumors
REFERENCE :
   JNCIAM Journal of the National Cancer Institute.  (Washington, DC)  V.1-60,
   1940-78.  For publisher information, see JJIND8.  Volume(issue)/page/year:
   54,495,1975

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 1780 uL/kg
TOXIC EFFECTS :
   Behavioral - altered sleep time (including change in righting reflex)
   Gastrointestinal - hypermotility, diarrhea
   Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
   ATDAEI Acute Toxicity Data. Journal of the American College of Toxicology,
   Part B. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128)  V.1-
   1990-  Volume(issue)/page/year: 12,574,1993

TYPE OF TEST            : LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 100 mg/m3
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   USKHAB Uspekhi Khimii. Progress in Chemistry.  For English translation, see
   RCRVAB. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)  V.1-    1932-
   Volume(issue)/page/year: 38,2173,1969

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 5660 uL/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Lungs, Thorax, or Respiration - dyspnea
   Gastrointestinal - other changes
REFERENCE :
   ATDAEI Acute Toxicity Data. Journal of the American College of Toxicology,
   Part B. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128)  V.1-
   1990-  Volume(issue)/page/year: 12,574,1993

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 750 mg/kg
TOXIC EFFECTS :
   Immunological Including Allergic - decreased immune response
REFERENCE :

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 1 mg/plate
REFERENCE :
   ENMUDM Environmental Mutagenesis.  (New York, NY)  V.1-9, 1979-87.  For
   publisher information, see EMMUEG.  Volume(issue)/page/year: 8(Suppl
   7),1,1986

Signal word Danger
WGK Germany1
Safety Statements
  • S16 Keep away from sources of ignition - No smoking 远离火源,禁止吸烟;
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后,立即用大量水冲洗并征求医生意见;
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护;
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时,立即求医(可能时出示标签);
    Risk Statements
    • R10 Flammable 易燃
    • R11 Highly flammable 非常易燃
    • R14 Reacts violently with water 遇水会猛烈反应
    • R19 May form explosive peroxides 可能生成易爆的过氧化物质
    • R20/21 Harmful by inhalation and in contact with skin 吸入及与皮肤接触有害
    • R21 Harmful in contact with skin 与皮肤接触有害
    • R34 Causes burns 会导致灼伤
    • R35 Causes severe burns 会导致严重灼伤
    • R36/38 Irritating to eyes and skin 对眼睛和皮肤有刺激性
    • R37 Irritating to respiratory system 刺激呼吸道
    • R40 Limited evidence of a carcinogenic effect 有限证据表明其致癌作用
      Precautionary statements
      • P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking. 远离热源/火花/明火/热的表面。——禁止吸烟。
      • P240 Ground/bond container and receiving equipment. 与地面接触/连接集装箱和接受设备。
      • P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
      • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
      • P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
      • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
      • P301+P310
      • P301+P330+P331+P310
      • P305+P351+P338
      • P305+P351+P338+P310
      • P310 Immediately call a POISON CENTER or doctor/physician. 立即呼救解毒中心或医生/医师。
      • P370 In case of fire: 在发生火灾的情况下:
      • P370+P378
      • P403+P233
      • P403+P235
      • P501 Dispose of contents/container to..… 处理内容物/容器.....
        Hazard statements
        • H314 Causes severe skin burns and eye damage 导致严重的皮肤灼伤和眼睛损伤
        • H351 Suspected of causing cancer 怀疑致癌
        • H225 Highly flammable liquid and vapour 高度易燃液体和蒸气
        • H335 May cause respiratory irritation 可能导致呼吸道刺激
        • H302 Harmful if swallowed 吞食有害
        • H226 Flammable liquid and vapour 易燃液体和蒸气
        • H332 Harmful if inhaled 吸入有害
        • H315 Causes skin irritation 会刺激皮肤
        • H318 Causes serious eye damage 严重伤害眼睛
        • H312 Harmful in contact with skin 皮肤接触有害
        • H301+H331
        • H331 Toxic if inhaled 吸入中毒
        • H336 May cause drowsiness or dizziness 肯能导致嗜睡或头晕
        • H373 May causes damage to organs through prolonged or repeated exposure 长期或频繁接触可能会损伤器官
          Personal Protective Equipment Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US) Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
          RTECSVV2710000
          Packing GroupII
          UN Number 1298 2924
          Storage condition Moisture Sensitive Store at RT. 储存温度2-8℃ 密封阴凉干燥保存。 密封阴凉干燥保存,充氩储存,储存温度2-8℃
          Hazard Codes 3 C T,F,C,Xn
          Hazard Class3/8
          Warnings 危化品目录(2015)
        • 用作硅酮油制造的中间体、憎水剂、分析用试剂、 聚硅酮液中间体、甲基硅油封头剂、抗水剂。
        • {ALF} Carbonyl compounds can be converted to their silyl enol ethers, e.g. with triethylamine in DMF: Org. Synth. Coll., 6, 327 (1988); 7, 424 (1990); 8, 460 (1993); or using catalysis with NaI: Org. Synth. Coll., 9, 573 (1998).
        • {ALF} The conversion of alcohols to alkyl chlorides requires catalysis, e.g. SeO2: J. Org. Chem., 53, 3634 (1988), or by DMSO: J. Org. Chem., 60, 2638 (1995). The same system is also effective in opening epoxides.
        • {ALF} For further details and reviews, see Appendix 4.
        • {ALF} For cleavage of ethers, see Sodium iodide, A15480.
        • {ALF} Conjugated enones give trimethylsilyloxydienes. For examples, see: Org. Synth. Coll., 6, 445 (1988); 7, 282 (1990). TMS chloride, LiBr and trimethylamine in THF is a convenient system for silylation of enones: Acta Chem. Scand., 43, 188 (1989). The same combination converts ɑ- and ß-diketones to their bis silyl enol ethers: Acta Chem. Scand., 43, 304 (1989). See also Trimethyl­silyl­ trifluoromethanesulfonate, A12535.
        • {uni_hamburg} Short: II/25C
        • {ALD} Merck: 14,10311
        • {uni_hamburg} Short: II/14a
        • {ALF} Silylation at carbon atoms is usually carried out using organometallic reagents, e.g. vinylmagnesium bromide: Org. Synth. Coll., 6, 1033 (1988). In aromatic rings, silyl groups can be introduced by directed metallation, followed by silylation; see e.g.: J. Org. Chem., 49, 4657 (1989). The silyl substituents can readily be replaced by electrophiles, allowing "abnormal" patterns of substitution. See 1,3-Dimethoxybenzene, A13380.
        • {ALD} Merck: 14,10311
        • Beilstein:4(3)1857
        • {uni_hamburg} Short: II/2
        • {ALF} For facile O-silylation of tertiary alcohols in the presence of Mg metal, see: Synlett, 1025 (2000).
        • 75-77-4 H23404 Chlorotrimethylsilane
三甲基氯硅烷

          化学属性

          Mol. FormulaC3H9ClSi
          Mol. Weight108.64
          Density0.856
          Autoignition Point752 °F
          Refractive index1.3850 to 1.3900
          Vapor Density3.7 (vs air)
          Boiling Point57
          Vapor Pressure100 mmHg ( 25 °C)
          Melting Point-40
          Flash Point-28°C(lit.)
          TSCAYes
          Solubility起反应
          Stability对湿度敏感
          Density0.856
          Mol. FormulaC3H9ClSi
          Mol. Weight108.64
          Mol. Weight249.93
          Density0.856
          Mol. FormulaC3
          Mol. Weight109