4-Aminoantipyrine 4-氨基安替吡啉

规格: 98%
CAS: 83-07-8
产品编号: H24967
MDL: MFCD00003145
品牌: INFI
Chemical Name4-Aminoantipyrine
CAS Number83-07-8
Synonym ######## 1,5-二甲基-2-苯基-4-氨基-3-吡唑啉酮 1-PHENYL-2,3-DIMETHYL-4-AMINO-3-PYRAZOLIN-5-ON 3-Pyrazolin-5-one, 4-amino-2,3-dimethyl-1-phenyl- 4 Amino 1,5 Dimethyl 2 Phenyl 3H Pyrazolone 4 Aminoantipyrine 4 Aminophenazone 4-AMINO-1,3-DIMETHYL-2-PHENYL-3-PYRAZOLONE 4-AMINO-1,5-DIMETHYL-2-PHENYL-1,2-DIHYDRO-PYRAZOL-3-ONE 4-AMINO-2,3-DIMETHYL-1-PHENYL-3-PYRAZOLINE-5-ONE 4-AMINOANTIPYRINE 4-AMINOPHENAZONE 4-Amino-1,5-Dimethyl-2-Phenyl-3H-Pyrazolone 4-Amino-2,3-dimethyl-1-phenyl-3-pyrazolin-5-one 4-Aminoantipyrine 4-Aminophenazone 4-Amminoantipirina 4-氨基-1,2-二氢-1,5-二甲基-2-苯基-3H-吡唑-3-酮 4-氨基-1,5-二甲基-2-苯基-3-吡唑啉酮 4-氨基安替吡啉 4-氨基安替比林 4-氨基安替比林；4-氨基非那宗；4-氨基-1,5-二甲基-2-苯基-3-吡唑啉酮 4-氨基非那宗 4-胺-1,5-二甲-2-苯-3H-吡唑-3-酮
PubChem Substance ID87561316
EC Number201-452-3
Beilstein Registry Number181635
MDL NumberMFCD00003145
Reaxys-RN181635
Merck Number591
Chemical Name Translation4-氨基安替比林
Wiswesser Line NotationT5NNVJ A1 BR& DZ E1
LabNetwork Molecule IDLN00193860
InChIInChI=1S/C11H13N3O/c1-8-10(12)11(15)14(13(8)2)9-6-4-3-5-7-9/h3-7H,12H2,1-2H3
GHS Symbol
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1700 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   BCFAAI Bollettino Chimico Farmaceutico.  (Societa Editoriale Farmaceutica,
   Via Ausonio 12, 20123 Milan, Italy)  V.33-    1894- Volume(issue)/page/year:
   117,638,1978

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 270 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - excitement
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 10,820,1960

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1200 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 99,171,1950

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 800 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   CCCCAK Collection of Czechoslovak Chemical Communications.  (Academic Press
   Inc. Ltd., 24-28 Oval Rd., London NW1 7DX, UK)  V.1-    1929-
   Volume(issue)/page/year: 47,636,1982

TYPE OF TEST            : DNA repair
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 312 ug/well
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 133,161,1984

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 5 umol/plate
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 206,317,1988

WGK Germany3
Hazard Codes Xn
Hazard statements
  • H302 Harmful if swallowed 吞食有害
  • H315 Causes skin irritation 会刺激皮肤
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
    Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves
    RTECSCD2480000
    Precautionary statements
    • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
    • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
    • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
    • P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
    • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
    • P301+P312
    • P301+P312+P330
    • P302+P352
    • P302+P352+P332+P313+P362+P364
    • P304+P340
    • P305+P351+P338
    • P305+P351+P338+P337+P313
    • P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适，呼叫解毒中心或医生/医师。
    • P321 Specific treatment (see … on this label). 具体治疗（见本标签上的）。
    • P330 Rinse mouth. 漱口
    • P332+P313
    • P337+P313
    • P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服，清洗后方可重新使用
    • P403+P233
    • P405 Store locked up. 上锁保管。
    • P501 Dispose of contents/container to..… 处理内容物/容器.....
      Signal word Warning
      Safety Statements
      • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
      • S36 Wear suitable protective clothing 穿戴适当的防护服；
      • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
        Risk Statements
        • R22 Harmful if swallowed 吞咽有害
        • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
          Storage condition 密封阴凉保存。 Store at RT. 密封阴凉避光保存。
        • A reagent for glucose determination in the presence of peroxidase and phenol
        • {TRC} Alhadeff, E., et al.: App. Biochem. Biotechnol., 146, 129 (2008),
        • {SA} Merck 14 ,591
        • {ALD} Merck: 14,591
        • {ALD} Merck: 14,591
        • Beilstein: 25,IV,3554
        • {MCE} [1]. Berno CR, et al. 4-Aminoantipyrine reduces toxic and genotoxic effects of doxorubicin, cisplatin, and cyclophosphamide in male mice. Mutat Res Genet Toxicol Environ Mutagen. 2016 Jul;805:19-24.
          • 83-07-8 H24967 4-Aminoantipyrine 4-氨基安替吡啉

          化学属性

          Mol. FormulaC11H13N3O
          Mol. Weight203
          Melting Point105-110
          Density0.8
          TSCAYes
          SolubilitySoluble in water (50 mg/ml).
          Stability对光、湿度和空气敏感

          *以上化合物性质及应用等信息仅供参考