Phenolphthalein 酚酞

规格: 98%
CAS: 77-09-8
产品编号: H25976
MDL: MFCD00005913
品牌: INFI
Chemical NamePhenolphthalein
Synonym Phenolphthalein {LY} Phenolphthalein {} {LY} Phenolphthalein {} {} {LY} Phenolphthalein {} {} {} {LY} Phenolphthalein {} {} {} {} {LY} Phenolphthalein {} {} {} {} {} {LY} Phenolphthalein {} {} {} {} {} {} {LY} Phenolphthalein {} {} {} {} {} {} {} {LY} Phenolphthalein {} {} {} {} {} {} {} {} {LY} Phenolphthalein {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {LY} Phenolphthalein {} {} {} {} {} {} {} {} {} {} {LY} Phenolphthalein {} {} {} {} {} {} {} {} {} {} {} {LY} Phenolphthalein {} {} {} {} {} {} {} {} {} {} {} {} {LY} Phenolphthalein {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Phenolphthalein {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Phenolphthalein {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Phenolphthalein {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Phenolphthalein {} {} {} {} {} {} {} {} {} {} {} {}
MDL NumberMFCD00005913
CAS Number77-09-8
PubChem Substance ID4764
EC Number201-004-7
Beilstein Registry Number18(3/4)1945
Merck Number7243
Reaxys-RN284423
Chemical Name Translation酚酞
InChIKeyKJFMBFZCATUALV-UHFFFAOYSA-N
Wiswesser Line NotationT56 BVO DHJ D- D-/R DQ 2
LabNetwork Molecule IDLN00195715
InChIInChI=1S/C20H14O4/c21-15-9-5-13(6-10-15)20(14-7-11-16(22)12-8-14)18-4-2-1-3-17(18)19(23)24-20/h1-12,21-22H
Canonical SMILESO=C1OC(C2=CC=C(O)C=C2)(C3=CC=C(O)C=C3)C4=C1C=CC=C4
GHS Symbol
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 281 gm/kg/2Y-C
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Endocrine - tumors
   Skin and Appendages - tumors
REFERENCE :
   NTPTR* National Toxicology Program Technical Report Series.  (Research
   Triangle Park, NC 27709) No.206-  Volume(issue)/page/year: NTP-TR-465,1996

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 364 gm/kg/2Y-C
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Kidney, Ureter, Bladder - tumors
   Endocrine - adrenal cortex tumors
REFERENCE :
   NTPTR* National Toxicology Program Technical Report Series.  (Research
   Triangle Park, NC 27709) No.206-  Volume(issue)/page/year: NTP-TR-465,1996

TYPE OF TEST            : LD - Lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >1 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NCNSA6 National Academy of Sciences, National Research Council,
   Chemical-Biological Coordination Center, Review.  (Washington, DC)
   Volume(issue)/page/year: 5,25,1953

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 500 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NCNSA6 National Academy of Sciences, National Research Council,
   Chemical-Biological Coordination Center, Review.  (Washington, DC)
   Volume(issue)/page/year: 5,30,1953

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - man
DOSE/DURATION           : 29 mg/kg
TOXIC EFFECTS :
   Gastrointestinal - gastritis
   Gastrointestinal - nausea or vomiting
   Kidney, Ureter, Bladder - other changes in urine composition
REFERENCE :
   PGMJAO Postgraduate Medical Journal.  (Blackwell Scientific Pub. Ltd., POB
   88, Oxford, UK) V.1-    1925-  Volume(issue)/page/year: 60,491,1984

TYPE OF TEST            : Micronucleus test
ROUTE OF EXPOSURE       : Oral
TEST SYSTEM             : Rodent - mouse
DOSE/DURATION           : 1680 mg/kg/14D (Continuous)
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 341,151,1995

TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Rodent - hamster Ovary
DOSE/DURATION           : 50 mg/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 341,151,1995

Precautionary statements
  • P201 Obtain special instructions before use. 使用前获取专门指示。
  • P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前，切勿操作。
  • P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking. 远离热源/火花/明火/热的表面。——禁止吸烟。
  • P240 Ground/bond container and receiving equipment. 与地面接触/连接集装箱和接受设备。
  • P241 Use explosion-proof electrical/ventilating/lighting/…/equipment. 使用防爆电气/通风/照明/ .../设备。
  • P241+P242+P243
  • P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
  • P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P281 Use personal protective equipment as required. 使用所需的个人防护装备。
  • P301+P310
  • P303+P361+P353
  • P304+P340
  • P304+P340+P312
  • P305+P351+P338
  • P308+
  • P308+P313
  • P311 Call a POISON CENTER or doctor/physician. 呼叫解毒中心或医生/医师。
  • P314 Get medical advice/attention if you feel unwell. 获取医疗咨询/就医，如果你觉得不舒服
  • P337+P313
  • P370+P378
  • P403+P233
  • P403+P235
  • P405 Store locked up. 上锁保管。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
    Hazard statements
    • H225 Highly flammable liquid and vapour 高度易燃液体和蒸气
    • H226 Flammable liquid and vapour 易燃液体和蒸气
    • H301+H311+H331
    • H341 Suspected of causing genetic defects 怀疑导致遗传性缺陷
    • H350 May cause cancer 可能致癌
    • H361 Suspected of damaging fertility or the unborn child 怀疑对生育能力或未出生婴儿造成伤害
    • H370 Causes damage to organs 导致器官损伤
      WGK Germany3
      Signal word Danger
      Personal Protective Equipment Eyeshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter dust mask type N95 (US), Eyeshields, Gloves
      RTECSSM8380000
      Safety Statements
      • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
      • S53 Avoid exposure - obtain special instructions before use 避免接触，使用前获得特别指示说明；
      • S16 Keep away from sources of ignition - No smoking 远离火源，禁止吸烟；
      • S20 When using do not eat or drink 使用时，不得进食，饮水；
      • S23 Do not breathe gas/fumes/vapour/spray (appropriate wording to be specified by the manufacturer) 不要吸入气体/烟雾/蒸汽/喷雾；
      • S60 This material and its container must be disposed of as hazardous waste 该物质及其容器必须作为危险废物处置；
      • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
      • S7/9 Keep container tightly closed and in a well-ventilated place 保持容器严格密闭，置于通风良好的场所；
      • S7 Keep container tightly closed 保存在严格密闭容器中；
      • S33 Take precautionary measures against static discharges 对静电采取预防措施；
      • S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；
      • S24 Avoid contact with skin 避免皮肤接触；
      • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
      • S24/25 Avoid contact with skin and eyes 避免皮肤和眼睛接触；
        Packing GroupIII
        UN Number 1993 UN1987 UN1986 1170 UN 1219 3/PG 2 UN 1993
        Risk Statements
        • R68 Possible risk of irreversible effects 可能有不可挽回的作用的危险
        • R62 Possible risk of impaired fertility 有削弱生殖能力的危险
        • R45 May cause cancer 可能致癌
        • R10 Flammable 易燃
        • R22 Harmful if swallowed 吞咽有害
        • R40 Limited evidence of a carcinogenic effect 有限证据表明其致癌作用
          Hazard Codes F F,T Xn Xi,F,Xn T Xn,T,F
          Storage condition 2-8°C, protect from light {LY} 2-8°C, protect from light Flammables area {} {LY} 2-8°C, protect from light {} {} {LY} 2-8°C, protect from light {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, pr
          Hazard Class3
        • 酸碱指示剂, 非水溶液滴定指示剂, 色谱分析试剂。
        • {ALD} Merck: 14,7243
        • Beilstein: 18,V,4,188
        • {uni_hamburg} Short: EINECS
        • {uni_hamburg} Short: IV/8A
        • {ALF} Acid-base indicator: pH 8.0 - 10.0.
        • {ALD} Merck: 14,7243
          • 77-09-8 H25976 Phenolphthalein 酚酞

          化学属性

          Mol. FormulaC20H14O4
          Mol. Weight318.33
          Melting Point 261 - 263 °C - lit.
          TSCAYes
          Density1.276
          SolubilitySoluble in alcohol. Slightly soluble in ether
          Flash Point11°(52°F)
          Appearance 白色粉末。熔点258-262℃，相对密度1.27。溶于10份醇，溶于稀碱溶液呈深红色，微溶于醚，不溶于水，无臭，无味。
          Stability对湿度敏感
          Boiling Point> 450 °C
          Refractive indexn20/D 1.377(lit.)

          *以上化合物性质及应用等信息仅供参考