4-Nitrotoluene 4-硝基甲苯

规格: 98%
CAS: 99-99-0
产品编号: H26930
MDL: MFCD00007366
品牌: INFI
Chemical Name4-Nitrotoluene
CAS Number99-99-0
EC Number202-808-0
Beilstein Registry Number1906911
MDL NumberMFCD00007366
Synonym 4-nitrotoluene 4-nitrotoluene hydride 4-nitrotoluene, (ar-nitro)-isomer 4-nitrotoluene, ion (1-) 4-nitrotoluene, ion (1-), hydrogen Toluene, p-nitro- p-Nitrophenylmethane p-nitrotoluene {} {LY} Toluene, p-nitro- {} {} {LY} Toluene, p-nitro- {} {} {} {LY} Toluene, p-nitro- {} {} {} {} {LY} Toluene, p-nitro- {} {} {} {} {} {LY} Toluene, p-nitro- {} {} {} {} {} {} {LY} Toluene, p-nitro- {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Toluene, p-nitro- {} {} {} {} {} {} {} {} {LY} Toluene, p-nitro- {} {} {} {} {} {} {} {} {} {LY} Toluene, p-nitro- {} {} {} {} {} {} {} {} {} {} {LY} Toluene, p-nitro- {} {} {} {} {} {} {} {} {} {} {} {LY} Toluene, p-nitro- {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Toluene, p-nitro- {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Toluene, p-nitro- {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {
Merck Number6650
PubChem Substance ID7473
Reaxys-RN1906911
Chemical Name Translation4-硝基甲苯
Wiswesser Line NotationWNR D1
LabNetwork Molecule IDLN00223489
InChIInChI=1S/C7H7NO2/c1-6-2-4-7(5-3-6)8(9)10/h2-5H,1H3
Canonical SMILESCC1=CC=C([N+]([O-])=O)C=C1
GHS Symbol
TYPE OF TEST            : LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 975 mg/m3
TOXIC EFFECTS :
   Brain and Coverings - recordings from specific areas of CNS
   Liver - fatty liver degeneration
   Blood - methemoglobinemia-carboxyhemoglobin
REFERENCE :
   GTPZAB Gigiena Truda i Professional'nye Zabolevaniya.  Labor Hygiene and
   Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
   V.1-36, 1957-1992. For publisher information, see MTPEEI
   Volume(issue)/page/year: 22(7),52,1978

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1231 mg/kg

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 1750 mg/kg
TOXIC EFFECTS :
   Brain and Coverings - recordings from specific areas of CNS
   Liver - fatty liver degeneration
   Blood - methemoglobinemia-carboxyhemoglobin
REFERENCE :
   GTPZAB Gigiena Truda i Professional'nye Zabolevaniya.  Labor Hygiene and
   Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
   V.1-36, 1957-1992. For publisher information, see MTPEEI
   Volume(issue)/page/year: 22(7),52,1978

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 940 mg/kg
TOXIC EFFECTS :
   Behavioral - ataxia
   Lungs, Thorax, or Respiration - cyanosis
   Lungs, Thorax, or Respiration - respiratory stimulation
REFERENCE :
   GISAAA Gigiena i Sanitariya.  For English translation, see HYSAAV.  (V/O
   Mezhdunarodnaya Kniga, 113095 Moscow, USSR)  V.1-    1936-
   Volume(issue)/page/year: 24(9),15,1959

TYPE OF TEST            : DNA repair
TEST SYSTEM             : Bacteria - Bacillus subtilis
DOSE/DURATION           : 5 mg/disc
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 170,11,1986

TYPE OF TEST            : Sister chromatid exchange
TEST SYSTEM             : Rodent - hamster Ovary
DOSE/DURATION           : 200 mg/L
REFERENCE :
   EMMUEG Environmental and Molecular Mutagenesis.  (Alan R. Liss, Inc., 41 E.
   11th St., New York, NY 10003)  V.10-    1987-  Volume(issue)/page/year:
   10(Suppl 10),1,1987

TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Rodent - hamster Ovary
DOSE/DURATION           : 500 mg/L
REFERENCE :
   EMMUEG Environmental and Molecular Mutagenesis.  (Alan R. Liss, Inc., 41 E.
   11th St., New York, NY 10003)  V.10-    1987-  Volume(issue)/page/year:
   10(Suppl 10),1,1987

TYPE OF TEST            : Unscheduled DNA synthesis
TEST SYSTEM             : Rodent - rat Liver
DOSE/DURATION           : 100 ug/L
REFERENCE :
   EMMUEG Environmental and Molecular Mutagenesis.  (Alan R. Liss, Inc., 41 E.
   11th St., New York, NY 10003)  V.10-    1987-  Volume(issue)/page/year:
   26,147,1995

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 10 ug/plate
REFERENCE :
   ENMUDM Environmental Mutagenesis.  (New York, NY)  V.1-9, 1979-87.  For
   publisher information, see EMMUEG.  Volume(issue)/page/year: 4,163,1982

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 65793 mg/kg
SEX/DURATION            : male 13 week(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Paternal Effects - spermatogenesis (incl. genetic material,
   sperm morphology, motility, and count)
   Reproductive - Paternal Effects - testes, epididymis, sperm duct
REFERENCE :
   NTPTR* National Toxicology Program Technical Report Series.  (Research
   Triangle Park, NC 27709) No.206-  Volume(issue)/page/year: NIH-93-3346

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 30 mg/kg
SEX/DURATION            : female 1 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Maternal Effects - uterus, cervix, vagina
REFERENCE :
   JTEHD6 Journal of Toxicology and Environmental Health.  (Hemisphere Pub.,
   1025 Vermont Ave., NW, Washington, DC 20005)  V.1-    1975/76-
   Volume(issue)/page/year: 36,13,1992

Signal word Danger
WGK Germany3
Safety Statements
  • S28 After contact with skin, wash immediately with plenty of ... (to be specified by the manufacturer) 皮肤接触后，立即用大量…（由生产厂家指定）冲洗；
  • S37 Wear suitable gloves 戴适当手套；
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
  • S61 Avoid release to the environment. Refer to special instructions/safety data sheet 避免释放到环境中，参考特别指示/安全收据说明书；
    Risk Statements
    • R23/24/25 Toxic by inhalation, in contact with skin and if swallowed 吸入，皮肤接触及吞食都有毒
    • R33 Danger of cumulative effects 有累积作用的危险
    • R51/53
      Precautionary statements
      • P203
      • P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
      • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
      • P262 Do not get in eyes, on skin, or on clothing. 不要接触眼睛，皮肤或衣服。
      • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
      • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
      • P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
      • P273 Avoid release to the environment. 避免释放到环境中。
      • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
      • P284 Wear respiratory protection.? 佩戴呼吸保护装置。
      • P301+P310
      • P301+P312+P330
      • P301+P316
      • P301+P317
      • P302+P352
      • P304+P340
      • P304+P340+
      • P304+P340+P310
      • P305+P351+P338
      • P307+P311
      • P308+P311
      • P308+P316
      • P311 Call a POISON CENTER or doctor/physician. 呼叫解毒中心或医生/医师。
      • P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适，呼叫解毒中心或医生/医师。
      • P314 Get medical advice/attention if you feel unwell. 获取医疗咨询/就医，如果你觉得不舒服
      • P316
      • P318
      • P319
      • P321 Specific treatment (see … on this label). 具体治疗（见本标签上的）。
      • P322 Specific measures (see …on this label). 具体治疗（见本标签上的）。
      • P330 Rinse mouth. 漱口
      • P361 Remove/Take off immediately all contaminated clothing. 立即去除/脱掉所有被污染的衣服。
      • P361+P364
      • P363 Wash contaminated clothing before reuse. 被污染的衣服洗净后方可重新使用。
      • P391 Collect spillage. Hazardous to the aquatic environment 收集对水环境有危害的泄漏物。
      • P403+P233
      • P405 Store locked up. 上锁保管。
      • P501 Dispose of contents/container to..… 处理内容物/容器.....
        RTECSXT3325000
        Packing GroupII
        UN Number 3446
        Hazard statements
        • H301 Toxic if swallowed 吞食有毒
        • H301+H311+H331
        • H302 Harmful if swallowed 吞食有害
        • H311 Toxic in contact with skin 皮肤接触中毒
        • H331 Toxic if inhaled 吸入中毒
        • H373 May causes damage to organs through prolonged or repeated exposure 长期或频繁接触可能会损伤器官
        • H411 Toxictoaquaticlifewithlonglastingeffects 对水生生物有毒性并具有长期影响。
          Personal Protective Equipment Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges dust mask type N95 (US), Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
          Hazard Codes 6.1 T,N T,N,F
          Storage condition Store at room temperature {LY} Store at room temperature {} {LY} Store at room temperature {} {} {LY} Store at room temperature {} {} {} {LY} Store at room temperature {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {}
          Hazard Class6.1
          Warnings 危化品目录(2015) 危险化学品
        • 校准仪器和装置；评价方法；工作标准；质量保证/质量控制；其他
        • {uni_hamburg} Short: II/27B
        • {uni_hamburg} Short: II/5
        • {uni_hamburg} Short: III/10a
        • {ALD} Merck: 14,6650
        • {ALF} In the presence of KOH, an unusual aerobic oxidation gives 4,4'-dinitrobibenzyl: Org. Synth. Coll., 4, 367 (1963). CrO3 in acetic anhydride gives the diacetate of 4-nitro-benzaldehyde: Org. Synth. Coll., 4, 713 (1963).
        • {ALD} Merck: 14,6650
        • Beilstein:5,323
          • 99-99-0 H26930 4-Nitrotoluene 4-硝基甲苯

          化学属性

          Mol. FormulaC7H7NO2
          Mol. Weight137
          Density1.39
          Flash Point106.11°C
          TSCAYes
          Melting Point52-54
          Boiling Point238
          Autoignition Point734 °F
          Vapor Density4.7 (vs air)
          Vapor Pressure5 mmHg ( 85 °C)
          Solubility0.35 G/L (20 ºC)
          Refractive index1.5332
          Stability对湿度敏感

          *以上化合物性质及应用等信息仅供参考