Histamine 组胺

规格: 97%
CAS: 51-45-6
产品编号: H27349
MDL: MFCD00005210
品牌: INFI
Chemical NameHistamine
CAS Number51-45-6
Alfabeta NameIMIDAZOLYLETHANAMINE H214()----
MDL NumberMFCD00005210
Synonym beta-Imidazolyl-4-ethylamine 2-imidazol-4-ylethylamine 1H-咪唑-4-乙胺 AURORA KA-668 5-Imidazoleethylamine 4-Imidazoleethylamine 4-(2-Aminoethyl)-1H-imidazole 1H-Imidazole-4-ethanamine 麥角胺 HISTAMIN 组胺 2-(4-Imidazolyl)ethylamine Imidazole-4-ethylamine Β-氨基乙基咪唑 2-咪唑基乙胺 2-(1H-imidazol-4-yl)-ethylamine Β-氨乙基甘噁啉 HISTAMINE 4-(2-aminoethyl)-imidazol 2-(1H-IMIDAZOL-4-YL)-ETHYLAMINE Eramin 组织胺，β-氨乙基咪唑
PubChem Substance ID774
EC Number200-100-6
Beilstein Registry Number2012
Chemical Name Translation组胺
Merck Number13,4739
Wiswesser Line NotationT5M CNJ D2Z
LabNetwork Molecule IDLN00011223
InChIInChI=1S/C5H9N3/c6-2-1-5-3-7-4-8-5/h3-4H,1-2,6H2,(H,7,8)
GHS Symbol
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - guinea pig
DOSE/DURATION           : 200 mg/kg
TOXIC EFFECTS :
   Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
   85IXA4 "Structure et Activite Pharmacodyanmique des Medicaments du Systeme
   Nerveux Vegetatif," Bovet, D., and F. Bovet-Nitti, New York, S. Karger, 1948
    Volume(issue)/page/year: -,718,1948

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 385 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - ataxia
   Lungs, Thorax, or Respiration - other changes
REFERENCE :
   KSRNAM Kiso to Rinsho.  Clinical Report.  (Yubunsha Co., Ltd., 1-5, Kanda
   Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan)  V.1-    1960-
   Volume(issue)/page/year: 13,89,1979

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 250 mg/kg
TOXIC EFFECTS :
   Autonomic Nervous System - other (direct) parasympathomimetic
   Behavioral - convulsions or effect on seizure threshold
REFERENCE :
   AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und
   Pharmakologie.  (Berlin, Ger.) V.110-253, 1925-66.  For publisher
   information, see NSAPCC.  Volume(issue)/page/year: 185,461,1937

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - guinea pig
DOSE/DURATION           : 5 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   85IXA4 "Structure et Activite Pharmacodyanmique des Medicaments du Systeme
   Nerveux Vegetatif," Bovet, D., and F. Bove

TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Rodent - mouse Embryo
DOSE/DURATION           : 200 mg/L
REFERENCE :
   DANKAS Doklady Akademii Nauk SSSR.  Proceedings of the Academy of Sciences
   of the USSR.  For English translation, see DBIOAM and DKBSAS.  (V/O
   Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-    1933-
   Volume(issue)/page/year: 282,173,1985

TYPE OF TEST            : DNA inhibition
TEST SYSTEM             : Human Cells - not otherwise specified
DOSE/DURATION           : 2 umol/L
REFERENCE :
   JIDEAE Journal of Investigative Dermatology.  (Williams & Wilkins Co., 428
   E. Preston St., Baltimore, MD 21202)  V.1-    1938- Volume(issue)/page/year:
   65,400,1975

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 200 mg/kg
SEX/DURATION            : male 1 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland,
   accessory glands
REFERENCE :
   PSEBAA Proceedings of the Society for Experimental Biology and Medicine.
   (Academic Press, Inc., 1 E. First St., Duluth, MN 55802)  V.1-    1903/04-
   Volume(issue)/page/year: 113,161,1963

Warnings IRRITANT
WGK Germany3
Hazard Codes Xn
Hazard statements
  • H315 Causes skin irritation 会刺激皮肤
  • H317 May cause an allergic skin reaction 可能导致皮肤过敏
  • H334 May cause allergy or asthma symptoms or breathing difficulties if inhaled 吸入可能导致过敏或哮喘症状或呼吸困难
  • H301 Toxic if swallowed 吞食有毒
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
  • H319 Causes serious eye irritation 严重刺激眼睛
    Personal Protective Equipment dust mask type N95 (US), Eyeshields, Faceshields, Gloves
    RTECSMS1050000
    Precautionary statements
      Signal word
      Safety Statements
        Risk Statements
        • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
        • R42/43
        • R22 Harmful if swallowed 吞咽有害
          UN Number UN 2811 6.1/PG 3
          Packing GroupIII
          Storage condition -20°C 储存温度-20°C
          Hazard Class6.1(b)
        • 内源性H1 和 H2 组胺受体激动剂；H1 激活并使Ca2+移动；H2 激活并刺激神经元中腺苷酸环化酶(adenylate cyclase)活性；激活NO合成酶；血管扩张剂。
        • {SA} Fu, L.W., et al., Endogenous histamine stimulates ischemically sensitive abdominal visceral afferents through H1 receptors. Am. J. Physiol. 273(6 Pt 2) , 2726, (1997) 摘要
        • {SA} Luo, T., and Leung, L.S., Endogenous Histamine Facilitates Long-term Potentiation In The Hippocampus During Walking. J. Neurosci. 30 , 7845-52, (2010) 摘要
        • {ALD} Merck: 14,4719
        • Beilstein: 25,IV,2049
        • {SA} Merck 14 ,4719
        • {uni_hamburg} Short: EINECS
        • {uni_hamburg} Short: III/5a
        • {uni_hamburg} Short: IV/18B
          • 51-45-6 H27349 Histamine 组胺

          化学属性

          Mol. FormulaC5H9N3
          Mol. Weight111
          Boiling Point167 °C/0.8 mmHg(lit.)
          Melting Point83-84 °C(lit.)
          Density1.14
          Stability易吸潮,对热敏感
          SolubilitySoluble in water, alcohol, and hot chloroform.

          *以上化合物性质及应用等信息仅供参考