Piperazine 无水哌嗪

规格: 99%
CAS: 110-85-0
产品编号: H29570
MDL: MFCD00005953
品牌: INFI
Chemical NamePiperazine, Anhydrous
CAS Number110-85-0
Alfabeta NamePIPERAZINE
MDL NumberMFCD00005953
EC Number203-808-3
Beilstein Registry Number102555
Synonym Piperazine {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {uni_hamburg} hexahydropyrazine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {uni_hamburg} hexahydro-pyridazine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {Chemicalbook} hexahydro-pyrazin {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {uni_hamburg} hexahydro-1,4-diazine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {uni_hamburg} Uvilon {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {uni_hamburg} Pyrazine hexahydride {} {} {} {} {} {} {} {} {
PubChem Substance ID4837
Merck Number7464
Chemical Name Translation哌嗪
Reaxys-RN102555
Wiswesser Line NotationT6M DMTJ
LabNetwork Molecule IDLN00159558
InChIInChI=1S/C4H10N2/c1-2-6-4-3-5-1/h5-6H,1-4H2
Canonical SMILESN1CCNCC1
GHS Symbol
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 4 mL/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   UCDS** Union Carbide Data Sheet.  (Union Carbide Corp., 39 Old Ridgebury
   Rd., Danbury, CT 06817)  Volume(issue)/page/year: 7/16/1965

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 600 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   BCFAAI Bollettino Chimico Farmaceutico.  (Societa Editoriale Farmaceutica,
   Via Ausonio 12, 20123 Milan, Italy)  V.33-    1894- Volume(issue)/page/year:
   103,414,1964

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1340 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NIIRDN Drugs in Japan (Ethical Drugs).  (Yakugyo Jiho Co., Ltd., Tokyo,
   Japan)  Volume(issue)/page/year: 6,635,1982

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1900 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   PBPHAW Progress in Biochemical Pharmacology.  (S. Karger AG, Postfach
   CH-4009 Basel, Switzerland) V.1-    1965-  Volume(issue)/page/year:
   1,542,1965

TYPE OF TEST            : LD50 - Let

Warnings 危化品目录(2015) IRRITANT
Signal word Danger
WGK Germany1
Safety Statements
  • S22 Do not breathe dust 不要吸入粉尘；
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
  • S61 Avoid release to the environment. Refer to special instructions/safety data sheet 避免释放到环境中，参考特别指示/安全收据说明书；
    Risk Statements
    • R34 Causes burns 会导致灼伤
    • R42/43
    • R52 Harmful to aquatic organisms 对水生生物有害
    • R52/53
    • R62 Possible risk of impaired fertility 有削弱生殖能力的危险
    • R63 Possible risk of harm to the unborn child 可能危害未出生婴儿
      Precautionary statements
      • P201 Obtain special instructions before use. 使用前获取专门指示。
      • P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
      • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
      • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
      • P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
      • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
      • P284 Wear respiratory protection.? 佩戴呼吸保护装置。
      • P301+P330+P331+P310
      • P303+P361+P353
      • P304+P340
      • P305+P351+P338
      • P305+P351+P338+P310
      • P310 Immediately call a POISON CENTER or doctor/physician. 立即呼救解毒中心或医生/医师。
      • P403+P233
      • P501 Dispose of contents/container to..… 处理内容物/容器.....
        Hazard statements
        • H314 Causes severe skin burns and eye damage 导致严重的皮肤灼伤和眼睛损伤
        • H361 Suspected of damaging fertility or the unborn child 怀疑对生育能力或未出生婴儿造成伤害
        • H317 May cause an allergic skin reaction 可能导致皮肤过敏
        • H334 May cause allergy or asthma symptoms or breathing difficulties if inhaled 吸入可能导致过敏或哮喘症状或呼吸困难
        • H302+H312
        • H302+H312+H332
          Personal Protective Equipment Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
          RTECSTK7800000
          Packing GroupIII
          UN Number 2579 UN 2579 8/PG 3 UN2579
          Storage condition Store at room temperature {LY} Store at room temperature Store in dark! {} {LY} Store at room temperature {} {} {LY} Store at room temperature {} {} {} {LY} Store at room temperature {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at r
          Hazard Codes 8 C,Xn
          Hazard Class8
          Restrict 危险品
        • 医药中间体，主要用于生产驱肠虫药磷酸哌嗪、枸橼酸哌嗪，以及氟奋及静、强痛定、利福平。六水哌嗪溶于乙醇，加入冰醋酸搅拌冷却即析出乙酸哌嗪，被用于合成激素类药物氢化泼尼松磷酸钠。六水哌嗪与乙酐反应制得驱虫药哌硝噻唑的中间体乙酰哌嗪。
        • {uni_hamburg} Short: II/25C
        • {uni_hamburg} Short: II/27B
        • {ALD} Merck:14,7464
        • {ALD} Merck:14,7464
        • Beilstein:23,4
          • 110-85-0 H29570 Piperazine 无水哌嗪

          化学属性

          Mol. FormulaC4H10N2
          Mol. Weight86.14
          Density1.1
          Boiling Point146-148
          Vapor Pressure0.8 mmHg ( 20 °C)
          Melting Point107-111
          Flash Point88°(190°F)
          TSCAYes
          Solubility易溶于水，水中溶解度:150 g/L (20°C)，易溶于甘油和乙二醇，溶于醇，实际上不溶于乙醚。10%水溶液的pH为10.8-11.8。
          Stability对光和空气敏感,易吸湿

          *以上化合物性质及应用等信息仅供参考