Acetonitrile 乙腈

规格: 99.9%,gradient HPLC grade
CAS: 75-05-8
产品编号: H35598
MDL: MFCD00001878
品牌: INFI
Chemical NameAcetonitrile
Synonym Ethyl nitrile Methane, cyano- Methanecarbonitrile Methyl cyanide RCRA waste number U003
CAS Number75-05-8
PubChem Substance ID87561760
EC Number200-835-2
Beilstein Registry Number741857
MDL NumberMFCD00001878
Reaxys-RN741857
Merck Number70
Chemical Name Translation乙腈
Wiswesser Line NotationNC1
LabNetwork Molecule IDLN00162999
InChIInChI=1S/C2H3N/c1-2-3/h1H3
GHS Symbol
TYPE OF TEST            : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 400 ppm/6H/2Y-I
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Liver - tumors
REFERENCE :
   NTPTR* National Toxicology Program Technical Report Series.  (Research
   Triangle Park, NC 27709) No.206-  Volume(issue)/page/year: NTP-TR-447,1996

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 3500 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single
   Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects,
   GKNT, 1982  Volume(issue)/page/year: -,16,1982

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Parenteral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1100 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single
   Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects,
   GKNT, 1982  Volume(issue)/page/year: -,16,1982

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 4480 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single
   Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects,
   GKNT, 1982  Volume(issue)/page/year: -,16,1982

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 850 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JOCMA7 Journal of Occupational Medicine. (Chicago, IL)  V.1-9,    1957-67.
   For publisher information, see:JJOMDZ  Volume(issue)/page/year: 1,634,1959

TYPE OF TEST

{ha

TYPE OF TEST            : Sex chromosome loss and nondisjunction
ROUTE OF EXPOSURE       : Inhalation
TEST SYSTEM             : Insect - Drosophila melanogaster
DOSE/DURATION           : 131 ppm
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 259,165,1991

TYPE OF TEST            : Sex chromosome loss and nondisjunction
TEST SYSTEM             : Yeast - Saccharomyces cerevisiae
DOSE/DURATION           : 47600 ppm
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 149,339,1985

TYPE OF TEST            : Sister chromatid exchange
TEST SYSTEM             : Rodent - hamster Ovary
DOSE/DURATION           : 5 gm/L
REFERENCE :
   EMMUEG Environmental and Molecular Mutagenesis.  (Alan R. Liss, Inc., 41 E.
   11th St., New York, NY 10003)  V.10-    1987-  Volume(issue)/page/year:
   10(Suppl 10),1,1987

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - hamster
DOSE                    : 400 mg/kg
SEX/DURATION            : female 8 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
   resorbed implants per total number of implants)
REFERENCE :
   TJADAB Teratology, The International Journal of Abnormal Development. (Alan
   R. Liss, Inc., 41 E. 11th St., New York, NY 10003)  V.1-    1968-
   Volume(issue)/page/year: 27,313,1983

TYPE OF TEST            : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - hamster
DOSE                    : 8000 ppm/1H
SEX/DURATION            : female 8 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
   Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
   TJADAB Teratology, The International Journal of Abnormal Development. (Alan
   R. Liss, Inc., 41 E. 11th St., New York, NY 10003)  V.1-    1968-
   Volume(issue)/page/year: 27,313,1983

TYPE OF TEST            : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - hamster
DOSE                    : 5000 ppm/1H
SEX/DURATION            : female 8 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
   resorbed implants per total number of implants)
   Reproductive - Specific Developmental Abnormalities - Central Nervous System
REFERENCE :
   TJADAB Teratology, The International Journal of Abnormal Development. (Alan
   R. Liss, Inc., 41 E. 11th St., New York, NY 10003)  V.1-    1968-
   Volume(issue)/page/year: 27,313,1983

TYPE OF TEST            :

WGK Germany2
Hazard Codes 3 F,Xi,Xn,T
Hazard statements
  • H225 Highly flammable liquid and vapour 高度易燃液体和蒸气
  • H302 Harmful if swallowed 吞食有害
  • H302+H312+H332
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H332 Harmful if inhaled 吸入有害
    Personal Protective Equipment Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
    RTECSAL7700000
    Precautionary statements
    • P201 Obtain special instructions before use. 使用前获取专门指示。
    • P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前,切勿操作。
    • P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking. 远离热源/火花/明火/热的表面。——禁止吸烟。
    • P233 Keep container tightly closed. ?保持容器密闭。
    • P240 Ground/bond container and receiving equipment. 与地面接触/连接集装箱和接受设备。
    • P241+P242+P243
    • P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
    • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
    • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西,喝水或吸烟。
    • P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
    • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
    • P302+P352+P312+P361+P364
    • P304+P340+P312
    • P305+P351+P338
    • P305+P351+P338+P337+P313
    • P308+P311
    • P403+P235
    • P405 Store locked up. 上锁保管。
    • P501 Dispose of contents/container to..… 处理内容物/容器.....
      Signal word Danger
      Safety Statements
      • S16 Keep away from sources of ignition - No smoking 远离火源,禁止吸烟;
      • S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套;
        Risk Statements
        • R10 Flammable 易燃
        • R11 Highly flammable 非常易燃
        • R20/21/22 Harmful by inhalation, in contact with skin and if swallowed 吸入、皮肤接触和不慎吞咽有害
        • R20/22 Harmful by inhalation and if swallowed 吸入和不慎吞咽有害
        • R23/24/25 Toxic by inhalation, in contact with skin and if swallowed 吸入,皮肤接触及吞食都有毒
        • R24 Toxic in contact with skin 与皮肤接触有毒
        • R36 Irritating to eyes 刺激眼睛
        • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
        • R41 Risk of serious damage to eyes 有严重损伤眼睛的危险
          UN Number 1648
          Packing GroupII
          Storage condition 密封阴凉处保存。 2-8°C 免阳光和紫外线照射,4℃下冷藏保存 充氩保存
          Hazard Class3
        • 乙腈最主要的用途是作溶剂。在石油工业中用于从石油烃中除去焦油、酚等物质的溶剂。在油脂工业中用作从动植物油中抽提脂肪酸的溶剂,在医药上用于甾族类药物的再结晶的反应介质。乙腈是医药(维生素B1),香料的中间体,是制造均三嗪氮肥增效剂的原料。也用作酒精的变性剂。此外,还可以用于合成乙胺、乙酸等,并在织物染色、照明工业中也有许多用途。
        • {ALF} Polar aprotic solvent for a wide variety of reactions, including nucleophilic substitutions, oxidations, reductions and organometallic reactions. Widely used with crown ethers for the generation of 'naked' anions from their salts; see, e.g. 18-Crown-6, A11249. Preferred solvent for RuO4 oxidations, due to its coordinating ability; see Ruthenium(III)­ chloride hydrate, 11043.
        • {ALF} For use in the mild conversion of amides to nitriles, see Benzamide, A10501.
        • {ALF} Undergoes the Ritter reaction with alcohols or olefins in the presence of acid to give N-substituted acetamides. For benzylic alcohols, modified conditions employing boron trifluoride etherate give high yields: Synth. Commun., 24, 601 (1994). For an example, see 4-Methyl­benzyl­ alcohol, A15315.
        • {uni_hamburg} Short: II/14a
        • {uni_hamburg} Short: II/19a
        • {ALD} Merck: 14,55 / Merck 14,70
        • {SNA}
        • 75-05-8 H35598 Acetonitrile
乙腈

          化学属性

          Mol. FormulaC2H3N
          Mol. Weight41.05
          Refractive index1.3430 to 1.3460
          Boiling Point81-82
          Density0.786
          Melting Point-48
          Flash Point10°C(lit.)
          TSCAYes
          Autoignition Point973 °F
          Vapor Density1.41 (vs air)
          Vapor Pressure72.8 mmHg
          SolubilityMISCIBLE
          Appearance liquid