Anisole 苯甲醚

规格: 99%, SpcDry, Water≤50 ppm (by K.F.), SpcSeal
CAS: 100-66-3
产品编号: H42859
MDL: MFCD00008354
品牌: INFI
Chemical NameAnisole
Synonym ANISOLE Ether, methyl phenyl- Methoxybenzene Methoxybenzene, Methyl phenyl ether Methyl phenyl ether ether,methylphenyl 甲氧基苯 苯基甲基醚 苯甲醚 茴香醚
CAS Number100-66-3
PubChem Substance ID7519
EC Number202-876-1
Beilstein Registry Number506892
MDL NumberMFCD00008354
Reaxys-RN506892
Merck Number669
Chemical Name Translation苯甲醚
Wiswesser Line Notation1OR
LabNetwork Molecule IDLN00163734
InChIInChI=1S/C7H8O/c1-8-7-5-3-2-4-6-7/h2-6H,1H3
GHS Symbol
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 3700 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Gastrointestinal - changes in structure or function of salivary glands
   Kidney, Ureter, Bladder - hematuria
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   6,378,1964

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 2800 mg/kg
TOXIC EFFECTS :
   Behavioral - tremor
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - excitement
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 88,400,1946

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 500 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JAFCAU Journal of Agricultural and Food Chemistry.  (American

TYPE OF TEST            : LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >5000 mg/m3
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   GTPZAB Gigiena Truda i Professional'nye Zabolevaniya.  Labor Hygiene and
   Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
   V.1-36, 1957-1992. For publisher information, see MTPEEI
   Volume(issue)/page/year: 28(6),43,1984

TYPE OF TEST            : DNA inhibition
TEST SYSTEM             : Human Lymphocyte
DOSE/DURATION           : 25 umol/L
REFERENCE :
   RCOCB8 Research Communications in Chemical Pathology and Pharmacology. (PJD
   Pub. Ltd., P.O. Box 966, Westbury, NY 11590)  V.1-    1970-
   Volume(issue)/page/year: 54,133,1986

WGK Germany2
Hazard statements
  • H226 Flammable liquid and vapour 易燃液体和蒸气
  • H315 Causes skin irritation 会刺激皮肤
  • H319 Causes serious eye irritation 严重刺激眼睛
    Personal Protective Equipment Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
    Precautionary statements
    • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
    • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
    • P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
    • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
    • P301+P310+P331
    • P302+P352+P332+P313+P362+P364
    • P303+P361+P353
    • P305+P351+P338
    • P332+P313
    • P337+P313
    • P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服，清洗后方可重新使用
    • P403+P233
    • P501 Dispose of contents/container to..… 处理内容物/容器.....
      Signal word Warning
      Safety Statements
      • S16 Keep away from sources of ignition - No smoking 远离火源，禁止吸烟；
      • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
      • S37/39 Wear suitable gloves and eye/face protection 穿戴适当的手套和眼睛/面保护；
        Risk Statements
        • R10 Flammable 易燃
        • R20 Harmful by inhalation 吸入有害
        • R38 Irritating to skin 刺激皮肤
        • R66 Repeated exposure may cause skin dryness or cracking 反复接触可能导致皮肤干燥或皴裂
          RTECSBZ8050000
          UN Number 2222
          Packing GroupIII
          Hazard Codes 3 Xn
          Storage condition Store at RT. 密封保存。 密封避光保存。
          Hazard Class3
          Warnings 危化品目录(2015)
          Restrict -
        • A biochemical for proteomics research.
        • {ALD} Merck:14,669
        • Beilstein:6(4)548
        • {ALFA} The rate of ortho-lithiation of anisole is accelerated dramatically in the presence of TMEDA, effective also in sub-stoichiometric amounts: Tetrahedron Lett., 35, 385 (1994). For discussion of the mechanism of ortho-lithiation, see: J. Org. Chem., 62, 3024 (1997). Although direct dilithiation with n-BuLi/TMEDA was unsuccessful, a sequence involving monolithiation, silylation and further lithiation at the 6-position gave the 2,6-disilyl derivative in 72% yield: J. Org. Chem., 49, 4657 (1984).
        • {ALD} Merck:14,669
        • {uni_hamburg} Short: II/19b
        • {ALFA} Widely used as a carbocation scavenger in the deblocking of, e.g. N-Boc or N-Cbz (Z) peptides with acidic reagents. Addition of anisole removes t-butyl or benzyl cations from the reaction mixture; see, e.g.: J. Chem. Soc., Chem. Commun., 922 (1976); Chem. Pharm. Bull., 25, 2929 (1977); Chem. Ber., 101, 3649 (1968).
          • 100-66-3 H42859 Anisole 苯甲醚

          化学属性

          Mol. FormulaC7H8O
          Mol. Weight108.13
          Refractive index1.5160 to 1.5190
          Boiling Point155 °C
          Density0.975
          Melting Point -37 °C
          Flash Point51.7 °C - 闭杯
          TSCAYes
          Autoignition Point887 °F
          Vapor Density3.7 (vs air)
          Vapor Pressure10 mmHg ( 42.2 °C)
          Solubility不溶于水,溶于乙醇、乙醚。
          Stability对光敏感
          Danger-Level-
          pH-:-
          Redox-

          *以上化合物性质及应用等信息仅供参考