Guanidine hydrochloride 盐酸胍

规格: 98%
CAS: 50-01-1
产品编号: H46705
MDL: MFCD00013026
品牌: INFI
Chemical NameGuanidine Hydrochloride
MDL NumberMFCD00013026
CAS Number50-01-1
Synonym Guanidine (hydrochloride) {LY} Guanidine (hydrochloride) {} {LY} Guanidine (hydrochloride) {} {} {LY} Guanidine (hydrochloride) {} {} {} {LY} Guanidine (hydrochloride) {} {} {} {} {LY} Guanidine (hydrochloride) {} {} {} {} {} {LY} Guanidine (hydrochloride) {} {} {} {} {} {} {LY} Guanidine (hydrochloride) {} {} {} {} {} {} {} {LY} Guanidine (hydrochloride) {} {} {} {} {} {} {} {} {LY} Guanidine (hydrochloride) {} {} {} {} {} {} {} {} {} {LY} Guanidine (hydrochloride) {} {} {} {} {} {} {} {} {} {} {LY} Guanidine (hydrochloride) {} {} {} {} {} {} {} {} {} {} {} {LY} Guanidine (hydrochloride) {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Guanidine (hydrochloride) {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Guanidine (hydrochloride) {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Guanidine (hydrochloride) {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY
PubChem Substance ID5742
EC Number200-002-3
Beilstein Registry Number3591990
Merck Number4562
Reaxys-RN3591990
Chemical Name Translation盐酸胍
Wiswesser Line NotationZYZUM &GH
LabNetwork Molecule IDLN00195266
InChIInChI=1S/CH5N3.ClH/c2-1(3)4;/h(H5,2,3,4);1H
Canonical SMILESNC(N)=N.Cl
GHS Symbol
TYPE OF TEST            : LD50 - Lethal

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - guinea pig
DOSE/DURATION           : 500 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und
   Pharmakologie.  (Berlin, Ger.) V.110-253, 1925-66.  For publisher
   information, see NSAPCC.  Volume(issue)/page/year: 131,171,1928

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intraarterial
SPECIES OBSERVED        : Rodent - guinea pig
DOSE/DURATION           : 500 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und
   Pharmakologie.  (Berlin, Ger.) V.110-253, 1925-66.  For publisher
   information, see NSAPCC.  Volume(issue)/page/year: 131,171,1928

TYPE OF T

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 200 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   HBAMAK "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." (Leipzig,
   Ger. Dem. Rep.)  Volume(issue)/page/year: 4,1352,1935

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - guinea pig
DOSE/DURATION           : 100 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   HBAMAK "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." (Leipzig,
   Ger. Dem. Rep.)  Volume(issue)/page/year: 4,1352,1935

TYPE OF TE

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Yeast - Saccharomyces cerevisiae
DOSE/DURATION           : 4 mmol/L
REFERENCE :
   BBRCA9 Biochemical and Biophysical Research Communications.  (Academic
   Press, Inc., 1 E. First St., Duluth, MN 55802)  V.1-    1959-
   Volume(issue)/page/year: 53,531,1973

WGK Germany1
Hazard statements
  • H302 Harmful if swallowed 吞食有害
  • H302+H332
  • H315 Causes skin irritation 会刺激皮肤
  • H319 Causes serious eye irritation 严重刺激眼睛
    Personal Protective Equipment Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter dust mask type N95 (US), Eyeshields, Faceshields, Gloves
    Precautionary statements
    • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
    • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
    • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
    • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
    • P301+P312
    • P301+P312+P330
    • P302+P350
    • P302+P352
    • P302+P352+P332+P313+P362+P364
    • P304+P340+P312
    • P305+P351+P338
    • P305+P351+P338+P337+P313
    • P321 Specific treatment (see … on this label). 具体治疗（见本标签上的）。
    • P330 Rinse mouth. 漱口
    • P332+P313
    • P337+P313
    • P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服，清洗后方可重新使用
    • P501 Dispose of contents/container to..… 处理内容物/容器.....
      Signal word Warning
      RTECSMF4300000
      Safety Statements
      • S22 Do not breathe dust 不要吸入粉尘；
      • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
        Risk Statements
        • R22 Harmful if swallowed 吞咽有害
        • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
        • R36/38 Irritating to eyes and skin 对眼睛和皮肤有刺激性
          Storage condition 2-8°C, sealed storage, away from moisture {LY} 2-8°C, sealed storage, away from moisture Hygroscopic Store at RT. {} {LY} 2-8°C, sealed storage, away from moisture {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {} {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {} {} {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {} {} {} {} {} {} {} {} {} {} {LY}
          Hazard Codes Xn Xn,Xi
        • 检定金、铱、锇、铂和钌。变性,RNA分离。
        • 强离液剂，用以变性和复性蛋白质。这种强劲的变性剂可以溶解不溶或变性的蛋白，如包涵体。这被用来作为复性到蛋白质或酶复性到活性状态的第一步。尿素和二硫苏糖醇（DTT）可能也是必要的。
        • {MCE} [2]. Saeed Emadi, et al. A comparative study on the aggregating effects of guanidine thiocyanate, guanidine hydrochloride and urea on lysozyme aggregation. Biochem Biophys Res Commun. 2014 Aug 8;450(4):1339-44.
        • {MCE} [3]. G Jung, et al. Guanidine hydrochloride inhibits Hsp104 activity in vivo: a possible explanation for its effect in curing yeast prions. Curr Microbiol. 2001 Jul;43(1):7-10.
        • {MCE} [4]. E C Herrmann Jr, et al. Prevention of death in mice infected with coxsackievirus A16 using guanidine HCl mixed with substituted benzimidazoles. Antiviral Res. 1982 Dec;2(6):339-46.
        • {ALD} Merck: 14,4562
        • {ALD} Merck: 14,4562
        • Beilstein: 3,IV,150
        • {uni_hamburg} Short: III/20a
        • {uni_hamburg} Short: III/31a
        • {MCE} [1]. Y Hagihara, et al. Guanidine hydrochloride-induced folding of proteins. J Mol Biol. 1993 May 20;231(2):180-4.
        • {MCE} [1]. Y Hagihara, et al. Guanidine hydrochloride-induced folding of proteins. J Mol Biol. 1993 May 20;231(2):180-4.
        • {MCE} [2]. Saeed Emadi,
          • 50-01-1 H46705 Guanidine hydrochloride 盐酸胍

          化学属性

          Mol. FormulaCH6ClN3
          Mol. Weight95.53
          Melting Point180-185
          Density1.18 g/mL at 25 °C(lit.)
          TSCAYes
          Solubility2280 G/L (20 ºC)
          Refractive indexn20/D 1.465
          Appearance 白色或微黄色块状物。 本品20℃时溶解度：200g/100g水，76g/100g甲醇，24g/100g乙醇。几乎不溶于丙酮、苯和乙醚。
          Stability易吸湿

          *以上化合物性质及应用等信息仅供参考