Urea 尿素

规格: 99%
CAS: 57-13-6
产品编号: H51085
MDL: MFCD00008022
品牌: INFI
Chemical NameUrea
Synonym Urea {LY} Urea {} {LY} Urea {} {} {LY} Urea {} {} {} {LY} Urea {} {} {} {} {LY} Urea {} {} {} {} {} {LY} Urea {} {} {} {} {} {} {LY} Urea {} {} {} {} {} {} {} {LY} Urea {} {} {} {} {} {} {} {} {LY} Urea {} {} {} {} {} {} {} {} {} {LY} Urea {} {} {} {} {} {} {} {} {} {} {LY} Urea {} {} {} {} {} {} {} {} {} {} {} {LY} Urea {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {LY} Urea {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Urea {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Urea {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Urea {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Urea {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Urea {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {}
Beilstein Registry Number635724
PubChem Substance ID1176
CAS Number57-13-6
EC Number200-315-5
MDL NumberMFCD00008022
Reaxys-RN635724
Merck Number9867
Chemical Name Translation尿素
Wiswesser Line NotationZVZ
LabNetwork Molecule IDLN00195939
InChIInChI=1S/CH4N2O/c2-1(3)4/h(H4,2,3,4)
Canonical SMILESNC(N)=O
GHS Symbol
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 821 gm/kg/1Y-C
TOXIC EFFECTS :
   Tumorigenic - neoplastic by RTECS criteria
   Blood - tumors
   Blood - lymphoma, including Hodgkin's disease
REFERENCE :
   JEPTDQ Journal of Environmental Pathology and Toxicology.  (Park Forest
   South, IL)  V.1-5(3), 1977-81(?).  For publisher information, see JEPOEC.
   Volume(issue)/page/year: 3(5-6),149,1980

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 394 gm/kg/1Y-C
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Blood - tumors
   Blood - lymphoma, including Hodgkin's disease
REFERENCE :
   JEPTDQ Journal of Environmental Pathology and Toxicology.  (Park Forest
   South, IL)  V.1-5(3), 1977-81(?).  For publisher information, see JEPOEC.
   Volume(issue)/page/year: 3(5-6),149,1980

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 8471 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   GISAAA Gigiena i Sanitari

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >5 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   APEPA2 Naunyn-Schmiedebergs Archiv fuer Pharmakologie und Experimentelle
   Pathologie.  (Berlin, Ger.) V.254-263, 1966-69.  For publisher information,
   see NSAPCC.  Volume(issue)/page/year: 257,296,1967

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intratracheal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 567 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Lungs, Thorax, or Respiration - dyspnea
   Blood - methemoglobinemia-carboxyhemoglobin
REFERENCE :
   GTPZAB Gigiena Truda i Professional'nye Zabolevaniya.  Labor Hygiene and
   Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
   V.1-36, 1957-1992. For publisher information, see MTPEEI
   Volume(issue)/page/year: 30(3),43,1986

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 5300 mg/kg
TOXIC EFFECTS :
   Behavioral - altered sleep time (including change in righting reflex)
   Behavioral - changes in motor activity (specific assay)
   Behavioral - antipsychotic
REFERENCE :
   OYYAA2 Oyo Yakuri.  Pharmacometrics.  (Oyo Yakuri Kenkyukai, CPO Box 180,
   Sendai 980-91, Japan) V.1-    1967-  Volume(issue)/page/year: 13,749,1977

TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Rodent - hamster Lung
DOSE/DURATION           : 13 gm/L
REFERENCE :
   GMCRDC Gann Monograph on Cancer Research.  (Plenum Pub. Corp., 233 Spring
   St., New York, NY 10013) No. 11-    1971-  Volume(issue)/page/year:
   27,95,1981

TYPE OF TEST            : Mutation in mammalian somatic cells
TEST SYSTEM             : Rodent - mouse Lymphocyte
DOSE/DURATION           : 265 mmol/L
REFERENCE :
   MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road,
   Eynsham, Oxford OX8 1JJ, UK) V.1- 1986-  Volume(issue)/page/year: 3,193,1988

TYPE OF TEST            : DNA damage
TEST SYSTEM             : Rodent - mouse Lymphocyte
DOSE/DURATION           : 628 mmol/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 203,155,1988

TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Human Leukocyte
DOSE/DURATION           : 50 mmol/L
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   25,980,1965

TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Rodent - hamster Fibroblast
DOSE/DURATION           : 16 gm/L/24H
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)

TYPE OF TEST            : Cytogenetic analysis
ROUTE OF EXPOSURE       : Oral
TEST SYSTEM             : Rodent - mouse
DOSE/DURATION           : 100 gm/kg/5D (Continuous)
REFERENCE :
   CYTOAN Cytologia.  (Japan Pub. Trading Co. (USA), 1255 Howard St., San
   Francisco, CA 94103) V.1-    1929-  Volume(issue)/page/year: 52,877,1987

TYPE OF TEST            : DNA dama

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraplacental
SPECIES OBSERVED        : Human - woman
DOSE                    : 1600 mg/kg
SEX/DURATION            : female 16 week(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - abortion
REFERENCE :
   BMJOAE British Medical Journal.  (British Medical Assoc., BMA House,
   Tavistock Sq., London WC1H 9JR, UK)  V.1-    1857- Volume(issue)/page/year:
   1,28,1971

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intrauterine
SPECIES OBSERVED        : Primate - monkey
DOSE                    : 6 gm/kg
SEX/DURATION            : female 18 week(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - abortion
REFERENCE :
   IJEBA6 Indian Journal of Experimental Biology.  (Publications & Information
   Directorate, CSIR, Hillside Rd., New Delhi 110 012, India)  V.1-    1963-
   Volume(issue)/page/year: 12,372,1974

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraplacental
SPECIES OBSERVED        : Human - woman
DOSE                    : 1400 mg/kg
SEX/DURATION            : female 16 week(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - abortion
REFERENCE :
   OBGNAS Obstetrics and Gynecology.  (Elsevier Science Pub. Co., Inc., 52
   Vanderbilt Ave., New York, NY 10017)  V.1-    1953- Volume(issue)/page/year:
   43,765,1974

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraplacental
SPECIES OBSERVED        : Human - woman
DOSE                    : 1600 mg/kg
SEX/DURATION            : female 16 week(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - abortion
REFERENCE :
   BJCPAT British Journal of Clinical Practice.  (Medical News Group, 1 Bedford
   St., London WC2E 9HD, UK)  V.10(10)-    1956- Volume(issue)/page/ye

RTECSYR6250000
WGK Germany1
Personal Protective Equipment Eyeshields, Gloves, half-mask respirator (US), multi-purpose combination respirator cartridge (US) Eyeshields, Gloves, half-mask respirator (EU), half-mask respirator (US), multi-purpose combination respirator cartridge (US) Eyeshields, Gloves Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
Signal word Warning
Safety Statements
  • S37 Wear suitable gloves 戴适当手套；
    Risk Statements
    • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
    • R38 Irritating to skin 刺激皮肤
      Precautionary statements
      • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
      • P302+P352
      • P305+P351+P338+P337+P313
      • P332+P313
      • P337+P313
        Hazard statements
        • H316 Causes mild skin irritation 会轻微的刺激皮肤
          Storage condition Store at room temperature {LY} Store at room temperature {} {LY} Store at room temperature {} {} {LY} Store at room temperature {} {} {} {LY} Store at room temperature {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at r
          Hazard Codes Xn,Xi Xn
        • 校准仪器和装置；评价方法；工作标准；质量保证/质量控制
        • {MCE} [2]. Pan M, et al. Urea: a comprehensive review of the clinical literature. Dermatol Online J. 2013 Nov 15;19(11):20392.
        • {MCE} [3]. Wang H, et al. Urea. Subcell Biochem. 2014;73:7-29.
        • {ALFA} For a procedure for conversion of carboxylic acids to primary amides by heating with urea, see: Org. Synth. Coll., 3, 768 (1955); 4, 513 (1963).
        • {ALFA} For the one-pot conversion of carboxylic acids to nitriles, by heating with urea in the presence of 1.5-2.0 moles of sulfamic acid, see: Chimia, 25, 94 (1971).
        • {ALFA} Reacts with alcohols on prolonged heating to give alkyl carbamates; see, e.g.: Org. Synth. Coll., 1, 140 (1941).
        • {uni_hamburg} Short: II/14a
        • {uni_hamburg} Short: II/19b
        • {ALFA} Widely used in diazotization reactions for the destruction of excess HNO2.
        • {MCE} [1]. Bennion BJ, et al. The molecular basis for the chemi
        • {MCE} [1]. Bennion BJ, et al. The molecular basis for the chemical denaturation of proteins by urea. Proc Natl Acad Sci U S A. 2003 Apr 29;100(9):5142-7.
          • 57-13-6 H51085 Urea 尿素

          化学属性

          Mol. FormulaCH4N2O
          Mol. Weight60.06
          Density1.335
          Melting Point132-135 °C
          TSCAYes
          SolubilitySoluble in water, alcohol, methanol, glycerol, benzene, and conc. HCl. Practically insoluble in chloroform, ether
          Refractive indexn20/D 1.40
          Appearance powder
          Boiling Point332.48 °C at 760 mmHg

          *以上化合物性质及应用等信息仅供参考