Roscovitine Roscovitine

规格: 98%
CAS: 186692-46-6
产品编号: H58589
MDL: MFCD02266401
品牌: INFI
Chemical NameRoscovitine
Synonym 2-(R)-[[9-(1-Methylethyl)-6-[(phenylmethyl)amino]-9H-purin-2-yl]amino]-1-butanol 6-(Benzylamino)-2(R)-[[1-(hydroxymethyl)propyl]amino]-9-isopropylpurine CYC202; CYC202; CYC 202; R-Roscovitine; Roscovitin; Roscovitine; Seliciclib.
MDL NumberMFCD02266401
PubChem Substance ID24278682
CAS Number186692-46-6
Chemical Name Translation(R)-2-((6-(苄基氨基)-9-异丙基-9H-嘌呤-2-基)氨基)丁-1-醇
FormulaC19H26N6O
IUPAC Name(R)-2-((6-(benzylamino)-9-isopropyl-9H-purin-2-yl)amino)butan-1-ol
InChIKeyBTIHMVBBUGXLCJ-OAHLLOKOSA-N
InChIInChI=1S/C19H26N6O/c1-4-15(11-26)22-19-23-17(20-10-14-8-6-5-7-9-14)16-18(24-19)25(12-21-16)13(2)3/h5-9,12-13,15,26H,4,10-11H2,1-3H3,(H2,20,22,23,24)/t15-/m1/s1
Canonical SMILESCC[C@@H](NC1=NC(NCC2=CC=CC=C2)=C3N=CN(C(C)C)C3=N1)CO
GHS Symbol
WGK Germany3
Personal Protective Equipment Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
Safety Statements
    Precautionary statements
      Storage condition Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
    • Seliciclib, also known as roscovitine and CYC202, is a n orally bioavailable, small-molecule cyclin-dependent kinase (CDK) inhibitor with potential proapoptotic and antineoplastic activities. Seliciclib primarily inhibits CDK2/E, CDK2/A, CDK7 and CDK9 by competing for their ATP binding sites, leading to a disruption of cell cycle progression. In addition, this agent appears to interfere with CDK-mediated phosphorylation of the carboxy-terminal domain of RNA polymerase II, inhibiting RNA polymerase II-dependent transcription, which may result in the down-regulation of antiapoptotic proteins such as induced myeloid leukemia cell differentiation protein Mcl-1.
    • {SA}
    • DeAzevado, W.F., et al., Inhibition of cyclin-dependent kinases by purine analogues: crystal structure of human cdk2 complexed with roscovitine. Eur. J. Biochem. 243 , 518-526, (1997) 摘要
    • {SA}
    • {SA} Chen, M.C., et al., Involvement Of CAMP In Nerve Growth Factor-triggered P35/Cdk5 Activation And Differentiation In PC12 Cells. Am. J. Physiol. Cell Physiol. 299 , C516-27, (2010) 摘要
    • {SA}
    • {SA} Merck 14 ,10240
    • 186692-46-6 H58589 Roscovitine
Roscovitine

      化学属性

      Mol. FormulaC19H26N6O
      Mol. Weight354
      Density1.3
      Boiling Point577.5
      Melting Point106-107
      Appearance Solid powder
      SolubilitySoluble in DMSO, not in water

      *以上化合物性质及应用等信息仅供参考