简介
应用举例
l Lithium Triethyllborohydride,Marek Zaidlewicz,Herbert C. Brown, Encyclopedia of Reagents for Organic Synthesis,2001
l Krishnamutthy, S. Schubert R.M Brown, H, C, J., Am Chem. Soc 1973, 95, 8486
l JACS, 1973
产品介绍
三乙基硼氢化锂是硼氢化锂的衍生物,一方面它是一种极强的亲核还原剂,同时,它又能还原羧酸、伯酰胺、脂肪族硝基化合物、肟、硫化物、磺酸、卤代芳烃等一些官能团,因此具有硼氢化钠等温和还原剂的高选择性能。此外,它在区域和立体选择还原中也显示出优良的特性。该化合物还被用于卤化物,磺酰基化合物的还原反应。产品应用前景广泛,具备持续的市场需求。
合成工艺
三乙基硼氢化锂制备方法简单,在氮气氛围下,利用氢化锂和三乙基硼在四氢呋喃溶液中反应,产品是以溶液形式存在,不存在任何废料,不存在环保问题。
应用实例
1. 文章研究一种不含重金属的 Fischer-Tropsch型反应,CO作为碳源,烷基硼烷在三乙基硼氢化锂的存在下进行多次CO插羰和还原,提供两个以上亚甲基组成的延长链,最后氧化处理得到醛产物。末端硼烷负责CO插入并促使酰基硼烷中间体还原为烷基硼烷[1]。
图片来源于期刊:J. Am. Chem. Soc. 2020, 142, 14064–14068
2 市售和廉价的三乙基硼氢化锂作为高效简单的催化剂,可用于许多醛酮的硼氢化,本篇文章主要优点是对醛酮的选择性,官能团耐受性好,在室温下无需反应溶剂通过一锅法将其转化为相应的1°和2°醇[2]。
图片来源于期刊:Green Chem., 2019, ,21, 1912-1915
参考文献:
[1] J. Am. Chem. Soc. 2020, 142, 14064–14068
[2] Green Chem., 2019, ,21, 1912-1915
Chemical Name | Lithium triethylborohydride |
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MDL Number | MFCD00011703 |
Beilstein Registry Number | 4151240 |
Synonym | Borate(1-), triethylhydro-, lithium, (T-4)- LITHIUM TRIETHYLBOROHYDRIDE-SOL. 1 M IN LITHIUM TRIETHYLHYDROBORATE Lithium borohydride thiethyl Lithium triethylborohydride, 1M solution in THF Lithium triethylborohydride, in tetrahydrofuran, 1M solution Lithium triethylhydridoborate Lithium triethylhydroborate Lithiumtriethylhydroborat SUPER-HYDRIDE (LITHIUM TRIETHYLBORO-HYDR IDE, 1.0M SOLUTION IN THF) SUPER-HYDRIDE(R) Super-Hydride® 溶液 lithium triethylborohydride solution lithium triethylhydridoborate, 1m in thf lithium triethylhydridoborate, 1m in thf, packaged under argon in resealable chemseal lithiumtriethylborohydride,calselect?lt, lithiumtriethylborohydride,calselect?lt,intetrahydrofuran super-hydride (lithium triethylbor |
CAS Number | 22560-16-3 |
Merck Number | 5544 |
PubChem Substance ID | 253660352 |
EC Number | 250-023-7 |
Chemical Name Translation | 三乙基硼氢化锂 |
Reaxys-RN | 4151240 |
LabNetwork Molecule ID | LN01330567 |
WGK Germany | 1 |
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Safety Statements | |
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Packing Group | I |
UN Number | 3399 |
Risk Statements | |
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Storage condition | Moisture Sensitive Flammables + water-Freezer (-20°C)e area 充氩保存 |
Precautionary statements | |
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Hazard statements | |
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Personal Protective Equipment | Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
Signal word | Danger |
Hazard Codes | 4.3 F,C |
Hazard Class | 4.3/3 |
Restrict | 危险品 |
*以上化合物性质及应用等信息仅供参考