1,1'-Carbonyldiimidazole N,N'-羰基二咪唑

规格: 98%
CAS: 530-62-1
产品编号: H77288
MDL: MFCD00005286
品牌: INFI
Chemical NameN,N'-Carbonyldiimidazole
CAS Number530-62-1
Alfabeta NameCARBONYLDIIMIDAZOLE NN-,'
MDL NumberMFCD00005286
Synonym N,N'-Carbonyldiimidazole {LY} N,N'-Carbonyldiimidazole N,N'-carbonyldiimidazole N,N-carbonyldiimidazole {} {LY} N,N'-Carbonyldiimidazole {} {} {LY} N,N'-Carbonyldiimidazole {} {} {} {LY} N,N'-Carbonyldiimidazole {} {} {} {} {LY} N,N'-Carbonyldiimidazole {} {} {} {} {} {LY} N,N'-Carbonyldiimidazole {} {} {} {} {} {} {LY} N,N'-Carbonyldiimidazole {} {} {} {} {} {} {} {LY} N,N'-Carbonyldiimidazole {} {} {} {} {} {} {} {} {LY} N,N'-Carbonyldiimidazole {} {} {} {} {} {} {} {} {} {LY} N,N'-Carbonyldiimidazole {} {} {} {} {} {} {} {} {} {} {LY} N,N'-Carbonyldiimidazole {} {} {} {} {} {} {} {} {} {} {} {LY} N,N'-Carbonyldiimidazole {} {} {} {} {} {} {} {} {} {} {} {} {LY} N,N'-Carbonyldiimidazole {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} N,N'-Carbonyldiimidazole {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} N,N'-Carbonyldiimidazole {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} N,N'-Carbonyldiimidaz
PubChem Substance ID68263
EC Number208-488-9
Beilstein Registry Number6826
Reaxys-RN6826
Merck Number1819
Chemical Name TranslationN,N'-羰基二咪唑
LabNetwork Molecule IDLN00121303
InChIInChI=1S/C7H6N4O/c12-7(10-3-1-8-5-10)11-4-2-9-6-11/h1-6H
Canonical SMILESO=C(N1C=NC=C1)N2C=NC=C2
GHS Symbol
Warnings MOISTURE SENSITIVE, KEEP COLD, CORROSIVE, STORED UNDER ARGON
WGK Germany2
Hazard Codes 8 C
Hazard statements
  • H302 Harmful if swallowed 吞食有害
  • H314 Causes severe skin burns and eye damage 导致严重的皮肤灼伤和眼睛损伤
  • H315 Causes skin irritation 会刺激皮肤
  • H318 Causes serious eye damage 严重伤害眼睛
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H351 Suspected of causing cancer 怀疑致癌
  • H360 May damage fertility or the unborn child 可能对生育能力或未出生婴儿造成伤害
    Personal Protective Equipment Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
    Precautionary statements
    • P201 Obtain special instructions before use. 使用前获取专门指示。
    • P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前，切勿操作。
    • P203
    • P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
    • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
    • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
    • P264+P265
    • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
    • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
    • P281 Use personal protective equipment as required. 使用所需的个人防护装备。
    • P301+P312
    • P301+P317
    • P301+P330+P331
    • P301+P330+P331+P310
    • P302+P352
    • P302+P361+P354
    • P303+P361+P353
    • P303+P361+P353+P310+P363
    • P304+P340
    • P304+P340+P310
    • P305+P351+P338
    • P305+P351+P338+P310
    • P305+P354+P338
    • P308+P313
    • P310 Immediately call a POISON CENTER or doctor/physician. 立即呼救解毒中心或医生/医师。
    • P316
    • P317
    • P318
    • P321 Specific treatment (see … on this label). 具体治疗（见本标签上的）。
    • P330 Rinse mouth. 漱口
    • P332+P313
    • P332+P317
    • P337+P313
    • P337+P317
    • P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服，清洗后方可重新使用
    • P362+P364
    • P363 Wash contaminated clothing before reuse. 被污染的衣服洗净后方可重新使用。
    • P405 Store locked up. 上锁保管。
    • P501 Dispose of contents/container to..… 处理内容物/容器.....
      Signal word Danger
      UN Number 1759 3263 UN 3263 8/PG 2 UN3263
      Storage condition RT, protect from light, stored under nitrogen {LY} RT, protect from light, stored under nitrogen {} {LY} RT, protect from light, stored under nitrogen {} {} {LY} RT, protect from light, stored under nitrogen {} {} {} {} {} {} {LY} RT, protect from light, stored under nitrogen {} {} {} {} {LY} RT, protect from light, stored under nitrogen {} {} {} {} {} {LY} RT, protect from light, stored under nitrogen {} {} {} {} {} {} {LY} RT, protect from light, stored under nitrogen {} {} {} {} {} {} {} {LY} RT, protect from light, stored under nitrogen {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} RT, protect from light, stored under nitrogen {} {} {} {} {} {} {} {} {} {LY} RT, protect from light, stored under nitrogen {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} RT, protect from light, stored under nitrogen {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {LY} RT, protect from light, stored under nitrogen {} {} {} {} {} {} {} {
      Safety Statements
      • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
      • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
      • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
        Risk Statements
        • R22 Harmful if swallowed 吞咽有害
        • R34 Causes burns 会导致灼伤
        • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
        • R36/38 Irritating to eyes and skin 对眼睛和皮肤有刺激性
        • R40 Limited evidence of a carcinogenic effect 有限证据表明其致癌作用
          Packing GroupII
          Hazard Class8
        • 多肽试剂，用于生化合成基团保护及蛋白质肽链的连接。作为合成三磷核苷、肽、和酯类的缩合剂；以及是合成酰基咪唑和吡藜酰胺的重要中间体。
        • {ALD} Merck:14,1819
        • {ALF} ɑß-Dihydroxyketones are converted toɑ-diketones: Synth. Commun., 23, 2219 (1993).
        • {ALF} Dehydrates aldoximes, including chiral oximes, to nitriles in high yield: J. Chem. Soc., Chem. Commun., 628 (1973); Synth. Commun., 12, 25 (1982). Ketoximes can be converted to amides by the spontaneous Beckmann rearrangement of imidazolium salts: Chem. Pharm. Bull., 32, 2560 (1984):
        • {ALF} Acylimidazolides can also be reduced to aldehydes by DIBAL-H. This reaction has been applied to N-protected amino acids: J. Chem. Soc., Chem. Commun., 79 (1979).
        • {ALD} Merck:14,1819
        • Beilstein:23(3/4)575
        • {TRC} Pierschbacher, M., et al.: Nature, 309, 30
        • {ALF} ß-Hydroxy amino acids are dehydrated to dehydroamino acids: Synthesis, 968 (1982).
        • {ALF} One-pot esterification of a carboxylic acid with t-BuOH occurs in the presence of DBU: Synthesis, 833 (1982). The reactivity of acyl imidazolides can be increased by N-alkylation: Chem. Pharm. Bull., 32, 5044 (1984).
        • {ALF} Reagent for peptide coupling via the acylimidazolide: Liebigs Ann. Chem., 609, 75 (1957); J. Am. Chem. Soc., 80, 4423 (1958); 82, 4596 (1960): J. Org. Chem., 27, 2094 (1962). For peptide reagents, see Appendix 6.
          • 530-62-1 H77288 1,1'-Carbonyldiimidazole N,N'-羰基二咪唑

          化学属性

          Mol. FormulaC7H6N4O
          Mol. Weight162.15
          Melting Point116 - 122 °C(lit.)
          TSCAT
          Density1.283
          Refractive indexn20/D 1.434
          Stability易吸潮
          Appearance 白色晶体。熔点115.5-116℃，不溶于水，溶于醇、醚。
          Solubility溶于二甲基甲酰胺（DMF）和水（与水反应）。
          Boiling Point288.83°C (rough estimate)

          *以上化合物性质及应用等信息仅供参考